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Protein Domain : IPR020902

Name  Actin/actin-like conserved site Short Name  Actin/actin-like_CS
Type  Conserved_site Description  Actin [, ]is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. These filaments interact with myosin to produce a sliding effect, which is the basis of muscular contraction and many aspects of cell motility, including cytokinesis. Each actin protomer binds one molecule of ATP and has one high affinity site for either calcium or magnesium ions, as well as several low affinity sites. Actin exists as a monomer in low salt concentrations, but filaments form rapidly as salt concentration rises, with the consequent hydrolysis of ATP. Actin from many sources forms a tight complex with deoxyribonuclease (DNase I) although the significance of this is still unknown. The formation of this complex results in the inhibition of DNase I activity, and actin loses its ability to polymerise. It has been shown that an ATPase domain of actin shares similarity with ATPase domains of hexokinase and hsp70proteins [, ].In vertebrates there are three groups of actin isoforms: alpha, beta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.Recently some divergent actin-like proteins have been identified in several species. These proteins include centractin (actin-RPV) from mammals, fungi yeast ACT5, Neurospora crassaro-4) and Pneumocystis carinii, which seems to be a component of a multi-subunit centrosomal complex involved in microtubule based vesicle motility (this subfamily is known as ARP1); ARP2 subfamily, which includes chicken ACTL, Saccharomyces cerevisiaeACT2, Drosophila melanogaster14D and Caenorhabditis elegansactC; ARP3 subfamily, which includes actin 2 from mammals, Drosophila 66B, yeast ACT4 and Schizosaccharomyces pombeact2; and ARP4 subfamily, which includes yeast ACT3 and Drosophila 13E.This entry contains a signature that picks up both actins and the actin-like proteins and corresponds to positions 106 to 118 in actins.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PS01132 PROSITE IPR020902

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

2 Found In

DB identifier Name Short Name Type
IPR004000 Actin-related protein Actin-related Family
IPR015623 Actin-related protein 3 (Arp3) Arp3 Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

99 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0082253 P10981 Drosophila melanogaster
FBpp0082597 P83967 Drosophila melanogaster
FBpp0076460 P32392 Drosophila melanogaster
FBpp0100124 P10987 Drosophila melanogaster
FBpp0071448 P53501 Drosophila melanogaster
FBpp0302793 P45888 Drosophila melanogaster
FBpp0085365 P02572 Drosophila melanogaster
FBpp0078131 P02574 Drosophila melanogaster
FBpp0082121 P45889 Drosophila melanogaster
FBpp0284137 Q297Q8 Drosophila pseudoobscura
FBpp0282261 Q299V2 Drosophila pseudoobscura
FBpp0275762 Q28WQ3 Drosophila pseudoobscura
FBpp0276529 B5E159 Drosophila pseudoobscura
FBpp0276787 Q29FE3 Drosophila pseudoobscura
FBpp0281840 Q29H46 Drosophila pseudoobscura
FBpp0282545 B5DVZ6 Drosophila pseudoobscura
FBpp0286990 Q29HM7 Drosophila pseudoobscura
FBpp0287004 Q29DN0 Drosophila pseudoobscura
FBpp0278212 B5DZR8 Drosophila pseudoobscura
FBpp0162786 B4L011 Drosophila mojavensis
FBpp0161217 B4KWX4 Drosophila mojavensis
FBpp0168928 B4KQM1 Drosophila mojavensis
FBpp0173556 B4KAA1 Drosophila mojavensis
FBpp0159719 B4K768 Drosophila mojavensis
FBpp0164372 B4L2U2 Drosophila mojavensis
FBpp0164529 B4L1G6 Drosophila mojavensis
FBpp0168812 B4KSC6 Drosophila mojavensis
FBpp0170368 B4KSP4 Drosophila mojavensis
FBpp0172439 B4KAD4 Drosophila mojavensis
FBpp0227688 B4LGZ8 Drosophila virilis