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Protein Domain : IPR029033

Name  Histidine phosphatase superfamily Short Name  His_PPase_superfam
Type  Family Description  The histidine phosphatase superfamily is a large and functionally diverse group of proteins. They share a conserved catalytic core centred on a histidine which becomes phosphorylated during the course of the reaction. The superfamily is mainly composed of phosphatases, but the best-studied member is dPGM (cofactor-dependent phosphoglycerate mutase). The superfamily contains two branches sharing very limited sequence similarity: histidine phosphatase clade-1 and clade-2 [].The larger clade-1 contains a wide variety of catalytic functions, thebest known being fructose 2,6-bisphosphatase (found in a bifunctionalprotein with 2-phosphofructokinase) and cofactor-dependentphosphoglycerate mutase. The latter is an unusual example of a mutaseactivity in the superfamily: the vast majority of members appear to bephosphatases. The bacterial regulatory protein phosphatase SixA is alsoin clade-1 and has a minimal, and possible ancestral-like structure,lacking the large domain insertions that contribute to binding of smallmolecules in clade-1 members.The smaller clade-2 contains predominantly eukaryotic proteins. Thecatalytic functions in members include phytase, glucose-1-phosphataseand multiple inositol polyphosphate phosphatase. The in vivo roles ofthe mammalian acid phosphatases in clade-2 are not fully understood,although activity against lysophosphatidic acid andtyrosine-phosphorylated proteins has been demonstrated.

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR000560 Histidine phosphatase superfamily, clade-2 His_Pase_superF_clade-2 Family
IPR013078 Histidine phosphatase superfamily, clade-1 His_Pase_superF_clade-1 Family

0 Contains

2 Cross References

Source . Name

Subject . Primary Identifier
SSF53254 SSF IPR029033

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

311 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074487 Q0KHQ6 Drosophila melanogaster
FBpp0074486 Q9VWH7 Drosophila melanogaster
FBpp0074746 Q9VW01 Drosophila melanogaster
FBpp0099919 Q9VAN7 Drosophila melanogaster
FBpp0072263 Q9W173 Drosophila melanogaster
FBpp0112189 A8JR97 Drosophila melanogaster
FBpp0083896 Q9VCE9 Drosophila melanogaster
FBpp0112188 Q86PB2 Drosophila melanogaster
FBpp0084975 Q8I0P9 Drosophila melanogaster
FBpp0084974 Q9VAD0 Drosophila melanogaster
FBpp0074747 Q9VW00 Drosophila melanogaster
FBpp0075157 Q9VV72 Drosophila melanogaster
FBpp0070849 Q9W438 Drosophila melanogaster
FBpp0083616 Q8T8W6 Drosophila melanogaster
FBpp0083617 Q86BN5 Drosophila melanogaster
FBpp0083618 Q86BN6 Drosophila melanogaster
FBpp0083537 Q9VD68 Drosophila melanogaster
FBpp0082089 Q9VGB6 Drosophila melanogaster
FBpp0077517 Q9VQ86 Drosophila melanogaster
FBpp0288799 Q9VR59 Drosophila melanogaster
FBpp0288482 B7Z082 Drosophila melanogaster
FBpp0288483 B7Z080 Drosophila melanogaster
FBpp0070350 O46084 Drosophila melanogaster
FBpp0282012 Q298M0 Drosophila pseudoobscura
FBpp0300366 I5ANX8 Drosophila pseudoobscura
FBpp0283608 Q29AB2 Drosophila pseudoobscura
FBpp0286091 Q29DG9 Drosophila pseudoobscura
FBpp0282923 Q29HG0 Drosophila pseudoobscura
FBpp0272859 Q29IW2 Drosophila pseudoobscura
FBpp0272122 Q29H62 Drosophila pseudoobscura