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Protein Domain : IPR019819

Name  Carboxylesterase type B, conserved site Short Name  Carboxylesterase_B_CS
Type  Conserved_site Description  Higher eukaryotes have many distinct esterases. Among the different types arethose which act on carboxylic esters (). Carboxyl-esterases havebeen classified into three categories (A, B and C) on the basis ofdifferential patterns of inhibition by organophosphates. The sequence of anumber of type-B carboxylesterases indicates [, , ]that the majority are evolutionary related. As is the case for lipases and serine proteases, the catalytic apparatus ofesterases involves three residues (catalytic triad): a serine, a glutamate oraspartate and a histidine.As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. This entry represents a well conserved site located in the N-terminal section, which contains a cysteine involved in a disulphide bond. Human esterase-D, also a type-B carboxylesterase, does not seem to be evolutionary related.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00941 PROSITE IPR019819

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

4 Found In

DB identifier Name Short Name Type
IPR002018 Carboxylesterase, type B CarbesteraseB Domain
IPR000997 Cholinesterase Cholinesterase Family
IPR001445 Acetylcholinesterase, insect Acylcholinesterase_insect Family
IPR016324 Thyroglobulin Thyroglobulin Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

178 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0081077 Q9VIB3 Drosophila melanogaster
FBpp0086625 Q8T016 Drosophila melanogaster
FBpp0080328 Q7KT70 Drosophila melanogaster
FBpp0075735 C9QP21 Drosophila melanogaster
FBpp0079331 P33438 Drosophila melanogaster
FBpp0071604 Q9W2F4 Drosophila melanogaster
FBpp0070594 Q9W4N5 Drosophila melanogaster
FBpp0082248 E1JIJ8 Drosophila melanogaster
FBpp0075082 P23654 Drosophila melanogaster
FBpp0075736 P18167 Drosophila melanogaster
FBpp0309035 A1ZA98 Drosophila melanogaster
FBpp0297876 Q9NGK5 Drosophila melanogaster
FBpp0086361 A1ZA97 Drosophila melanogaster
FBpp0290294 Q9VIC6 Drosophila melanogaster
FBpp0290296 Q9VDP5 Drosophila melanogaster
FBpp0290894 B6IDZ4 Drosophila melanogaster
FBpp0081065 Q9VIC7 Drosophila melanogaster
FBpp0281201 Q294P1 Drosophila pseudoobscura
FBpp0274977 B5DQN9 Drosophila pseudoobscura
FBpp0274978 B5DQP0 Drosophila pseudoobscura
FBpp0275447 Q29G93 Drosophila pseudoobscura
FBpp0277646 Q291D5 Drosophila pseudoobscura
FBpp0278755 B5DZ86 Drosophila pseudoobscura
FBpp0278751 B5DZ85 Drosophila pseudoobscura
FBpp0278754 Q28WT2 Drosophila pseudoobscura
FBpp0281189 B5DWB0 Drosophila pseudoobscura
FBpp0281193 B5DWA7 Drosophila pseudoobscura
FBpp0283747 Q299S3 Drosophila pseudoobscura
FBpp0284749 Q294N3 Drosophila pseudoobscura
FBpp0285663 B5DK96 Drosophila pseudoobscura