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Protein Domain : IPR029058

Name  Alpha/Beta hydrolase fold Short Name  AB_hydrolase
Type  Domain Description  This entry represent the Alpha/Beta hydrolase fold.The alpha/beta hydrolase fold []is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 strands connected by helices []. The enzymes are believed to have diverged from a common ancestor, preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best conserved structural features of the fold. Esterase (EST) from Pseudomonas putidais a member of the alpha/beta hydrolase fold superfamily of enzymes [].In most of the family members the beta-strands are parallels, but some have an inversion of the first strands, which gives it an antiparallel orientation. The catalytic triad residues are presented on loops. One of these is the nucleophile elbow and is the most conserved feature of the fold. Some other members lack one or all of the catalytic residues. Some members are therefore inactive but others are involved in surface recognition. The ESTHER database []gathers and annotates all the published information related to gene and protein sequences of this superfamily [].

Publication Counts Displayer

11 Child Features

DB identifier Name Short Name Type
IPR002018 Carboxylesterase, type B CarbesteraseB Domain
IPR013094 Alpha/beta hydrolase fold-3 AB_hydrolase_3 Domain
IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain Peptidase_S9 Domain
IPR002925 Dienelactone hydrolase Dienelactn_hydro Domain
IPR029059 Alpha/beta hydrolase fold-5 AB_hydrolase_5 Domain
IPR000073 Alpha/beta hydrolase fold-1 AB_hydrolase_1 Domain
IPR001031 Thioesterase Thioesterase Domain
IPR003140 Phospholipase/carboxylesterase/thioesterase PLipase/COase/thioEstase Domain
IPR000675 Cutinase Cutinase Domain
IPR010333 Bacterial virulence VirJ Domain
IPR000383 X-Pro dipeptidyl-peptidase-like domain X-Pro-like_dom Domain

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:3.40.50.1820 GENE3D IPR029058
SSF53474 SSF IPR029058

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

2135 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073652 P06607 Drosophila melanogaster
FBpp0088646 Q9GU50 Drosophila melanogaster
FBpp0088652 Q8IRK7 Drosophila melanogaster
FBpp0088651 Q9I7V6 Drosophila melanogaster
FBpp0088648 Q8T0V2 Drosophila melanogaster
FBpp0088645 Q8IGI1 Drosophila melanogaster
FBpp0088649 Q9I7V7 Drosophila melanogaster
FBpp0088644 Q7KVN1 Drosophila melanogaster
FBpp0081077 Q9VIB3 Drosophila melanogaster
FBpp0082113 Q9VG50 Drosophila melanogaster
FBpp0303630 Q4V566 Drosophila melanogaster
FBpp0084522 Q9VB91 Drosophila melanogaster
FBpp0072791 Q9W045 Drosophila melanogaster
FBpp0079688 Q9VKT1 Drosophila melanogaster
FBpp0085583 Q7JR83 Drosophila melanogaster
FBpp0087911 Q7JQU9 Drosophila melanogaster
FBpp0087910 Q5U191 Drosophila melanogaster
FBpp0078895 Q9VMC9 Drosophila melanogaster
FBpp0071870 Q7K274 Drosophila melanogaster
FBpp0071872 Q8MLS7 Drosophila melanogaster
FBpp0070812 Q9W495 Drosophila melanogaster
FBpp0077328 O76462 Drosophila melanogaster
FBpp0072612 Q9W0H3 Drosophila melanogaster
FBpp0112159 Q9VDX1 Drosophila melanogaster
FBpp0080368 Q8IP31 Drosophila melanogaster
FBpp0084449 Q9VB93 Drosophila melanogaster
FBpp0084450 Q9VB94 Drosophila melanogaster
FBpp0289183 Q9V9P0 Drosophila melanogaster
FBpp0074279 Q9VX01 Drosophila melanogaster
FBpp0099523 Q59E63 Drosophila melanogaster