Genomics
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3 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0209477 | eIF4E-5[GD13873] | Drosophila melanogaster | |
| FBal0237155 | eIF4E-5[KK111009] | Drosophila melanogaster | |
| FBal0275928 | eIF4E-5[NIG.8277R] | Drosophila melanogaster |
7 Clones
| Secondary Identifier | DB identifier |
|---|---|
| AT10032 | FBcl0031999 |
| bs43a04 | FBcl0054439 |
| bs17g01 | FBcl0054441 |
| bs26c12 | FBcl0054443 |
| EC13944 | FBcl0069793 |
| FI21952 | FBcl0743578 |
| 214255.22 | FBcl0424561 |
3 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0035823:1 | eIF4E-5:1 |
| FBgn0035823:2 | eIF4E-5:2 |
| FBgn0035823:3 | eIF4E-5:3 |
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0076747-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0076747-3-prime-utr | Drosophila melanogaster |
Other
71 Pathways
- IRS-mediated signalling,
- Formation of RNA Pol II elongation complex,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- RNA Polymerase II Pre-transcription Events,
- Insulin receptor recycling,
- RNA Polymerase II Transcription Initiation,
- Regulation of AMPK activity via LKB1,
- RNA Pol II CTD phosphorylation and interaction with CE,
- Deadenylation-dependent mRNA decay,
- Signaling Pathways,
- Regulation of Rheb GTPase activity by AMPK,
- Gene Expression,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- Metabolism of proteins,
- PKB-mediated events,
- DINR-mediated activation,
- Formation of a pool of free 40S subunits,
- Transcription,
- mTOR signalling,
- Formation of the Early Elongation Complex,
- PI3K Cascade,
- RNA Polymerase II Transcription,
- Elongation arrest and recovery,
- IRS-related events,
- Processing of Capped Intronless Pre-mRNA,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Cleavage of Growing Transcript in the Termination Region,
- Metabolism of mRNA,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Translation,
- mRNA Capping,
- Processing of Intronless Pre-mRNAs,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- Transport of the SLBP independent Mature mRNA,
- IRS activation,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- SLBP independent Processing of Histone Pre-mRNAs,
- TOR signaling pathway,
- Ribosomal scanning and start codon recognition,
- Transport of the SLBP Dependant Mature mRNA,
- 3' -UTR-mediated translational regulation,
- Processing of Capped Intron-Containing Pre-mRNA,
- mRNA Processing,
- Antiviral mechanism by IFN-stimulated genes,
- ISG15 antiviral mechanism,
- IGF1R signaling cascade,
- Post-Elongation Processing of Intronless pre-mRNA,
- Cytokine Signaling in Immune system,
- Transport of Mature Transcript to Cytoplasm,
- Post-Elongation Processing of the Transcript,
- Eukaryotic Translation Initiation,
- Release of eIF4E,
- Insulin receptor signalling cascade,
- mTORC1-mediated signalling,
- RNA Polymerase II Transcription Termination,
- Interferon Signaling,
- Deadenylation of mRNA,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- Immune System,
- IRS-related events triggered by IGF1R,
- Cap-dependent Translation Initiation,
- RNA Polymerase II Promoter Escape,
- Insulin signaling pathway,
- RNA Polymerase II Transcription Elongation,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- Insulin receptor mediated signaling,
- Translation initiation complex formation,
- Metabolism of RNA,
- GTP hydrolysis and joining of the 60S ribosomal subunit
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 38878 | NCBI Entrez Gene identifiers | FBgn0035823 |
| 64305 | BioGRID | FBgn0035823 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| TrEMBL data set | http://www.ebi.ac.uk/trembl/ |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
2 Introns
| DB identifier |
Organism . Name |
|---|---|
| intron_FBgn0035823:1_FBgn0035823:2 | Drosophila melanogaster |
| intron_FBgn0035823:2_FBgn0035823:3 | Drosophila melanogaster |
22 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF4E-5 | none | 0.32825756 | 19067489 | |
| Lipid storage | eIF4E-5 | none | 0.437180844 | 19067489 | |
| Hedgehog signaling | eIF4E-5 | Increased Hedgehog reporter activity | 3.25 | 16311596 | |
| Cell size and cell-cycle regulation (1) | eIF4E-5 | none | sp | 16496002 | |
| Combinatorial effect with methyl methanesulphonate (2) | eIF4E-5 | none | sp | 19543366 | |
| Heat nociception (1) | eIF4E-5 | none | 0.38 | 21074052 | |
| Heat nociception (1) | eIF4E-5 | none | 0.38 | 21074052 | |
| Heart development and function (1) | eIF4E-5 | none | 1 | 20371351 | |
| Heart development and function (1) | eIF4E-5 | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | eIF4E-5 | none | -0.88235294117647 | 19520911 | |
| Serratia marcescens infection (1) | eIF4E-5 | none | -0.553571428571428 | 19520911 | |
| Notch pathway regulation (4) | eIF4E-5 | none | 0 | 19363474 | |
| Notch pathway regulation (4) | eIF4E-5 | none | 0 | 19363474 | |
| Hh pathway regulation | eIF4E-5 | Downregulation of Hh pathway | -0.27361273955117 | 17903264 | |
| Hh pathway regulation | eIF4E-5 | none | 0.22308208236292 | 17903264 | |
| Adiposity regulation (1) | eIF4E-5 | none | 0.012 | 20074523 | |
| RTK-Ras-ERK pathway regulation (1) | eIF4E-5 | Decreased ERK phosphorylation after EGF stimulation | -1.65 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF4E-5 | none | -0.23 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF4E-5 | none | 0.02 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF4E-5 | none | -0.8 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF4E-5 | none | -0.49 | 23263283 | |
| Glycosylation regulation (1) | eIF4E-5 | none | sp | 21203496 |
