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Protein : FBpp0085367 D. melanogaster

Primary Accession  ? P24785 Organism . Name  Drosophila melanogaster
MD5 Checksum  8365aa49436e08634a70b9e7e96d77e9 UniProt Accession  P24785
UniProt Name  MLE_DROME GenBank Identifier  AAF57297
Is UniProt Canonical  true Is Fragment  false
Length  1293 Molecular Weight  143661
Name  Dosage compensation regulator Secondary Identifier  FBpp0085367

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1 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0002774 CG11680 mle maleless FlyBase D. melanogaster


Protein --> Gene + chromosomal location and length of the gene.


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0 Components

3 Cross References

Source . Name

Subject . Primary Identifier
Dm.2901 UniGene FBpp0085367
NP_476641.1 RefSeq FBpp0085367
NP_724440.1 RefSeq FBpp0085367

3 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set
Reactome data set  

1 Ec Numbers

Identifier Description  

1 Locations

Located On . Primary Identifier
Start End Strand
2R 1862698 1868199 -1

39 Pathways

Identifier Name
104743 mRNA Processing
91611 pre-mRNA splicing
94469 mRNA Splicing
98175 Processing of Capped Intron-Containing Pre-mRNA
105951 Immune System
88681 Innate Immune System
105649 Gene Expression
34578 TRAF6 Mediated Induction of proinflammatory cytokines
113278 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
100899 Transcription
112247 Cytokine Signaling in Immune system
167467 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
120387 RIP-mediated NFkB activation via ZBP1
120480 ZBP1(DAI) mediated induction of type I IFNs
120468 Cytosolic sensors of pathogen-associated DNA
131727 TRAF6 mediated NF-kB activation
139163 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
112945 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
29229 NOD1/2 Signaling Pathway
91838 Toll Like Receptor TLR1:TLR2 Cascade
109018 Toll Like Receptor 2 (TLR2) Cascade
85024 Toll Like Receptor TLR6:TLR2 Cascade
32391 Toll Like Receptor 9 (TLR9) Cascade
101443 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
92018 MyD88:Mal cascade initiated on plasma membrane
90914 Activated TLR4 signalling
109895 Toll Like Receptor 4 (TLR4) Cascade
87458 MyD88 dependent cascade initiated on endosome
79068 Toll Like Receptor 7/8 (TLR7/8) Cascade
30810 Toll Like Receptor 5 (TLR5) Cascade

8 Protein Domains

DB identifier Name Short Name Type
IPR027417 P-loop containing nucleoside triphosphate hydrolase P-loop_NTPase Domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal DNA/RNA_helicase_DEAD/DEAH_N Domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain Helicase_ATP-bd Domain
IPR001650 Helicase, C-terminal Helicase_C Domain
IPR014720 Double-stranded RNA-binding domain dsRNA-bd_dom Domain
IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site DNA/RNA_helicase_DEAH_CS Conserved_site
IPR011709 Domain of unknown function DUF1605 DUF1605 Domain
IPR007502 Helicase-associated domain Helicase-assoc_dom Domain

1 Transcripts

DB identifier Gene
FBtr0086031 mle