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Gene : IntS1 D. melanogaster

DB identifier  ? FBgn0034964 Secondary Identifier  ? CG3173
Name  ? Integrator 1 Source  FlyBase
  • synonyms:
  • CG3173,
  • FBgn0034964,
  • Int1,
  • FBan0003173

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6 Alleles

DB identifier Symbol Allele Class Organism
FBal0279700 IntS1[MI06493]   Drosophila melanogaster
FBal0215908 IntS1[EY18784]   Drosophila melanogaster
FBal0202994 IntS1[GD10348]   Drosophila melanogaster
FBal0239782 IntS1[MAN1-Delta296]   Drosophila melanogaster
FBal0222900 IntS1[5-HA-2821]   Drosophila melanogaster
FBal0273543 IntS1[NIG.3173R]   Drosophila melanogaster

21 Clones

Secondary Identifier DB identifier
EK142505 FBcl0006006
EK054633 FBcl0006904
AT07688 FBcl0009467
AT03037 FBcl0010063
AT13749 FBcl0010167
AT08085 FBcl0010255
AT11382 FBcl0010355
EP16424 FBcl0076465
EP17028 FBcl0078153
GH10159 FBcl0129397
GH19129 FBcl0129505
GM23014 FBcl0144587
GM17647 FBcl0144633
SD03850 FBcl0278041
SD10569 FBcl0278235
SD05534 FBcl0278297
SD15874 FBcl0279931
CK01.170C.B10 FBcl0442209
CK01.133D.F11 FBcl0476158
214501.63 FBcl0476160
214565.70 FBcl0476165

3 Exons

DB identifier Symbol
FBgn0034964:1 IntS1:1
FBgn0034964:2 IntS1:2
FBgn0034964:3 IntS1:3

1 Transcripts

DB identifier Gene
FBtr0072168 IntS1

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0072168-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072168-3-prime-utr Drosophila melanogaster

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0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
37840 NCBI Entrez Gene identifiers FBgn0034964
63421 BioGRID FBgn0034964

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 552.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 624.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 594.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 570.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 778.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 302.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 738.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 743.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 382.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 821.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 611.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 623.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 459.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1024.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 603.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 624.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 684.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 665.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 485.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 482.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 613.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 531.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 684.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 546.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 622.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1135.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 372.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 753.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 523.0
FBgn0034964 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 421.0

2 Introns

DB identifier
Organism . Name
intron_FBgn0034964:1_FBgn0034964:2 Drosophila melanogaster
intron_FBgn0034964:2_FBgn0034964:3 Drosophila melanogaster

23 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage IntS1 none 1.249210932   19067489
Lipid storage IntS1 none 0.46017313   19067489
ERK signaling IntS1 ERK activation reduced weak   17086199
Innate immunity IntS1 Increased IMD reporter activity np   16163390
Cell size and cell-cycle regulation (1) IntS1 none sp   16496002
Microtubule assembly and organization IntS1 none np   18463163
Mutant human huntingtin aggregation IntS1 Increased mutant human huntingtin aggregation >= 2   19789644
Muscle morphogenesis and function (1) IntS1 Lethal np   20220848
Muscle morphogenesis and function (3) IntS1 none np   20220848
Heat nociception (1) IntS1 Developmentally lethal 0   21074052
Heart development and function (1) IntS1 none 1   20371351
Notch pathway regulation (4) IntS1 Completely lethal (pupal) sp   19363474
PGN-induced dJNK phosphorylation IntS1 Decreased P-JNK protein expression with PGN -1.99 15 min PGN induction 19893628
Notch induced transcription IntS1 none 5.0056 without Notch stimulation 20959007
Notch induced transcription IntS1 Upregulation of Notch pathway after Notch stimulation 2.7273 N(delta)ecn Notch stimulation 20959007
Notch induced transcription IntS1 Downregulation of Notch pathway after Notch stimulation -4.5298 N(delta)ecn Notch stimulation 20959007
RTK-Ras-ERK pathway regulation (1) IntS1 none 0.56 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) IntS1 none -0.51 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) IntS1 none 0.31 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) IntS1 none -0.94 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation IntS1 none 1.07   23263283
Glycosylation regulation (1) IntS1 Increased mannose Chp glycosylation sp   21203496
Glycosylation regulation (2) IntS1 Effect on Chp glycosylation np   21203496

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