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Protein : FBpp0081378 D. melanogaster

Primary Accession  ? O61444 Organism . Name  Drosophila melanogaster
MD5 Checksum  13e166d546b56e6fca2f77207f5ff9bd UniProt Accession  O61444
UniProt Name  O61444_DROME GenBank Identifier  AAF54258
Is UniProt Canonical  true Is Fragment  false
Length  424 Molecular Weight  47534
Name  Stress activated MAP kinase kinase 4 Secondary Identifier  FBpp0081378

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1 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0024326 CG9738 Mkk4 MAP kinase kinase 4 FlyBase D. melanogaster


Protein --> Gene + chromosomal location and length of the gene.


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0 Components

4 Cross References

Source . Name

Subject . Primary Identifier
NP_477353.1 RefSeq FBpp0081378
NP_001262375.1 RefSeq FBpp0081378
Dm.2942 UniGene FBpp0081378
NP_001163551.1 RefSeq FBpp0081378

3 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set
Reactome data set  

1 Ec Numbers

Identifier Description

3 Locations

Located On . Primary Identifier
Start End Strand
3R 4474447 4476233 -1
3R 4474447 4476233 -1
3R 4474447 4476233 -1

28 Pathways

Identifier Name
171890 Cellular Senescence
170887 Oxidative Stress Induced Senescence
144067 Cellular responses to stress
105951 Immune System
88681 Innate Immune System
34578 TRAF6 Mediated Induction of proinflammatory cytokines
139259 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
82500 MAP kinase activation in TLR cascade
167327 FCERI mediated MAPK activation
166867 Fc epsilon receptor (FCERI) signaling
91838 Toll Like Receptor TLR1:TLR2 Cascade
109018 Toll Like Receptor 2 (TLR2) Cascade
85024 Toll Like Receptor TLR6:TLR2 Cascade
32391 Toll Like Receptor 9 (TLR9) Cascade
101443 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
92018 MyD88:Mal cascade initiated on plasma membrane
90914 Activated TLR4 signalling
109895 Toll Like Receptor 4 (TLR4) Cascade
87458 MyD88 dependent cascade initiated on endosome
79068 Toll Like Receptor 7/8 (TLR7/8) Cascade
30810 Toll Like Receptor 5 (TLR5) Cascade
91529 Toll-Like Receptors Cascades
99649 Toll Like Receptor 3 (TLR3) Cascade
99643 MyD88-independent cascade
34570 TRIF-mediated TLR3/TLR4 signaling
92313 Toll Like Receptor 10 (TLR10) Cascade
81183 MyD88 cascade initiated on plasma membrane
145760 IRAK2 mediated activation of TAK1 complex

4 Protein Domains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site

3 Transcripts

DB identifier Gene
FBtr0334320 Mkk4
FBtr0300443 Mkk4
FBtr0081892 Mkk4