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Gene : BubR1 D. melanogaster

DB identifier  ? FBgn0263855 Secondary Identifier  ? CG7838
Name  ? Bub1-related kinase Source  FlyBase
  • synonyms:
  • BcDNA:LD23835,
  • CG7838,
  • FBgn0025458,
  • BUB1,
  • DmBUB1,
  • FBgn0022226,
  • FBgn0069180,
  • bub related one,
  • BUBR1,
  • 31/13,
  • FBan0007838,
  • l(2)k06109,
  • CG 7838,
  • mcl(2)Z1525,
  • dBUB1,
  • l(2)k03113,
  • FBgn0263855

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23 Alleles

DB identifier Symbol Allele Class Organism
FBal0249209 BubR1[MI01546]   Drosophila melanogaster
FBal0277488 BubR1[Scer\UAS.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0277489 BubR1[kd.Scer\UAS.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0277490 BubR1[Cenp-C.Scer\UAS.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0155010 BubR1[D1326N] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0262707 BubR1[GL00236]   Drosophila melanogaster
FBal0263046 BubR1[GLV21065]   Drosophila melanogaster
FBal0095840 BubR1[unspecified]   Drosophila melanogaster
FBal0191840 BubR1[Rev1] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0064563 BubR1[k06109] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0157255 BubR1[Scer\UAS.Exel]   Drosophila melanogaster
FBal0064564 BubR1[k03113] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0187959 BubR1[c00394]   Drosophila melanogaster
FBal0157256 BubR1[DN.Scer\UAS] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0191768 BubR1[T:Avic\GFP-S65T]   Drosophila melanogaster
FBal0212240 BubR1[dsRNA.cGa]   Drosophila melanogaster
FBal0190699 BubR1[T:Disc\RFP-mRFP]   Drosophila melanogaster
FBal0287536 BubR1[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0198850 BubR1[GD10778]   Drosophila melanogaster
FBal0247987 BubR1[A1204K.PR]   Drosophila melanogaster
FBal0247988 BubR1[A1204K.T:Avic\GFP-S65T]   Drosophila melanogaster
FBal0247989 BubR1[KEN.T:Disc\RFP-mRFP]   Drosophila melanogaster
FBal0222324 BubR1[NP4609]   Drosophila melanogaster

43 Clones

Secondary Identifier DB identifier
DPiM_LD23835 FBcl0741510
bs67f08 FBcl0051065
EK072836 FBcl0064958
EK263634 FBcl0064990
EK187509 FBcl0064996
EK255851 FBcl0065030
EK185754 FBcl0065036
EK089837 FBcl0065646
EP05907 FBcl0080545
EP09209 FBcl0080547
LD17380 FBcl0158745
LD12353 FBcl0160009
LD16179 FBcl0160010
LD17759 FBcl0160012
LD18419 FBcl0160014
LD06986 FBcl0160027
LD39483 FBcl0175202
LD25038 FBcl0175203
LD24007 FBcl0175232
LD40040 FBcl0175237
LD35813 FBcl0175239
LD26503 FBcl0175242
LD40862 FBcl0175247
LD25638 FBcl0175255
LD29402 FBcl0175261
LD23835 FBcl0175276
RE60294 FBcl0227471
EC052327 FBcl0301654
EC055041 FBcl0301655
EC054841 FBcl0301656

5 Exons

DB identifier Symbol
FBgn0263855:5 BubR1:5
FBgn0263855:4 BubR1:4
FBgn0263855:3 BubR1:3
FBgn0263855:2 BubR1:2
FBgn0263855:1 BubR1:1

1 Transcripts

DB identifier Gene
FBtr0086032 BubR1

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0086032-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0086032-3-prime-utr Drosophila melanogaster

Interactions

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Other

0 Pathways

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
35522 NCBI Entrez Gene identifiers FBgn0263855
33758 NCBI Entrez Gene identifiers FBgn0263855
61428 BioGRID FBgn0263855

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

4 Introns

DB identifier
Organism . Name
intron_FBgn0263855:5_FBgn0263855:4 Drosophila melanogaster
intron_FBgn0263855:4_FBgn0263855:3 Drosophila melanogaster
intron_FBgn0263855:3_FBgn0263855:2 Drosophila melanogaster
intron_FBgn0263855:2_FBgn0263855:1 Drosophila melanogaster

38 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage BubR1 none 3.089957731   19067489
Lipid storage BubR1 none 1.784805888   19067489
Multipolar division BubR1 Centrosome clustering defects weak   18662975
Cell cycle regulation (1) BubR1 Aneuploid cells, decreased mitotic index, decreased number of cells in prometaphase and metaphase, central spindle defects, lagging chromatids sp   15616552
Cell cycle regulation (2) BubR1 Increased S DNA content or increased number of aneuploid cells, decreased G2 DNA content np   15616552
Intracellular Listeria monocytogenes infection BubR1 Increased GFP protein expression moderate   16020693
Cell size and cell-cycle regulation (1) BubR1 none sp   16496002
Cell size and cell-cycle regulation (1) BubR1 none sp   16496002
Cell size and cell-cycle regulation (1) BubR1 none sp   16496002
Cell size and cell-cycle regulation (2) BubR1 none 1.252   16496002
Cell size and cell-cycle regulation (3) BubR1 none 441   16496002
Mitosis BubR1 Chromosome misalignment np   17412918
C. trachomatis infection BubR1 C. trachomatis infection down np   18369471
Muscle morphogenesis and function (1) BubR1 none np   20220848
Muscle morphogenesis and function (1) BubR1 none np   20220848
Heat nociception (1) BubR1 none -1.17   21074052
Heart development and function (1) BubR1 none 1   20371351
Serratia marcescens infection (1) BubR1 none 0.0641025641025641   19520911
Notch pathway regulation (4) BubR1 Loss of bristles 3   19363474
Notch pathway regulation (4) BubR1 Loss of bristles, bristle morphology defects sp   19363474
Self-renewal and differentiation in neural stem cells BubR1 GFP aggregates number, GFP aggregates size, neuroblast less large cells, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with unchanged neuroblast cell size, neuroblast underproliferation, lethal sp   21549331
Notch pathway regulation (2) BubR1 none np C96-GAL4 20493818
Notch pathway regulation (2) BubR1 Up- and downregulation of Notch pathway sp C96-GAL4 20493818
Notch pathway regulation (2) BubR1 Up- and downregulation of Notch pathway; adult wing veins: broader; adult wing posterior compartment: smaller, opaque; wing disc NRE:EGFP: up, broader; wing disc myrRFP: accumulation sp en-GAL4 20493818
Notch pathway regulation (2) BubR1 Up- and downregulation of Notch pathway; wing disc NRE:EGFP: up, down, gap; wing disc myrRFP: accumulation, reduced; lethal sp en-GAL4 20493818
Notch pathway regulation (3) BubR1 none np   20493818
Blood cell homeostasis regulation (1) BubR1 none np   20540764
Blood cell homeostasis regulation (2) BubR1 none np   20540764
Actin organization and cell morphology (1) BubR1 none np   19265526
Actin organization and cell morphology (2) BubR1 none np   19265526

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