Genomics
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2 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0214940 | eIF4E-4[GD6700] | Drosophila melanogaster | |
| FBal0233587 | eIF4E-4[KK105485] | Drosophila melanogaster |
30 Clones
4 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0035709:4 | eIF4E-4:4 |
| FBgn0035709:3 | eIF4E-4:3 |
| FBgn0035709:2 | eIF4E-4:2 |
| FBgn0035709:1 | eIF4E-4:1 |
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0076963-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0076963-3-prime-utr | Drosophila melanogaster |
Other
71 Pathways
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- RNA Pol II CTD phosphorylation and interaction with CE,
- Processing of Capped Intron-Containing Pre-mRNA,
- Metabolism of proteins,
- Eukaryotic Translation Initiation,
- Transport of Mature Transcript to Cytoplasm,
- Post-Elongation Processing of Intronless pre-mRNA,
- Deadenylation-dependent mRNA decay,
- IRS-mediated signalling,
- Regulation of Rheb GTPase activity by AMPK,
- Antiviral mechanism by IFN-stimulated genes,
- IRS-related events triggered by IGF1R,
- RNA Polymerase II Transcription Elongation,
- Release of eIF4E,
- Translation initiation complex formation,
- mRNA Capping,
- Gene Expression,
- Signaling Pathways,
- mTOR signalling,
- Regulation of AMPK activity via LKB1,
- ISG15 antiviral mechanism,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- IRS activation,
- Ribosomal scanning and start codon recognition,
- Cap-dependent Translation Initiation,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- Processing of Intronless Pre-mRNAs,
- Deadenylation of mRNA,
- TOR signaling pathway,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- Transport of the SLBP Dependant Mature mRNA,
- Transport of the SLBP independent Mature mRNA,
- Insulin signaling pathway,
- Metabolism of mRNA,
- Cleavage of Growing Transcript in the Termination Region,
- mTORC1-mediated signalling,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- Formation of a pool of free 40S subunits,
- Translation,
- Formation of the Early Elongation Complex,
- SLBP independent Processing of Histone Pre-mRNAs,
- PKB-mediated events,
- DINR-mediated activation,
- RNA Polymerase II Promoter Escape,
- Immune System,
- IGF1R signaling cascade,
- RNA Polymerase II Pre-transcription Events,
- Insulin receptor signalling cascade,
- Elongation arrest and recovery,
- RNA Polymerase II Transcription,
- mRNA Processing,
- Formation of RNA Pol II elongation complex,
- Processing of Capped Intronless Pre-mRNA,
- 3' -UTR-mediated translational regulation,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Cytokine Signaling in Immune system,
- Transcription,
- Post-Elongation Processing of the Transcript,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Interferon Signaling,
- Insulin receptor recycling,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- Insulin receptor mediated signaling,
- IRS-related events,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- RNA Polymerase II Transcription Initiation,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- RNA Polymerase II Transcription Termination,
- Metabolism of RNA,
- PI3K Cascade
1 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 38743 | NCBI Entrez Gene identifiers | FBgn0035709 |
9 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| TrEMBL data set | http://www.ebi.ac.uk/trembl/ |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
10 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF4E-4 | none | 2.824689431 | 19067489 | |
| Lipid storage | eIF4E-4 | none | 0.724673597 | 19067489 | |
| ERK signaling | eIF4E-4 | ERK activation reduced | weak | 17086199 | |
| Cell size and cell-cycle regulation (1) | eIF4E-4 | none | sp | 16496002 | |
| Combinatorial effect with methyl methanesulphonate (2) | eIF4E-4 | Synthetic lethal with methyl methanesulphonate | sp | 19543366 | |
| RTK-Ras-ERK pathway regulation (1) | eIF4E-4 | Decreased ERK phosphorylation after EGF stimulation | -2.34 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF4E-4 | none | -0.99 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF4E-4 | none | -0.43 | 30 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF4E-4 | none | -1.44 | 10 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF4E-4 | none | 0.82 | 23263283 |
