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Protein : FBpp0077850 D. melanogaster

Primary Accession  ? O02194 Organism . Name  Drosophila melanogaster
MD5 Checksum  893cf5f37d29f252f17e5859073bd085 UniProt Accession  O02194
UniProt Name  PSN_DROME GenBank Identifier  AGB94804
Is UniProt Canonical  true Is Fragment  false
Length  541 Molecular Weight  59304
Name  Presenilin homolog Secondary Identifier  FBpp0077850

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Uni Prot Comments Displayer

Protein Sequence Displayer


1 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0019947 CG18803 Psn Presenilin FlyBase D. melanogaster


Protein --> Gene + chromosomal location and length of the gene.


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0 Components

5 Cross References

Source . Name

Subject . Primary Identifier
Dm.3254 UniGene FBpp0077850
NP_001262111.1 RefSeq FBpp0077850
NP_524184.1 RefSeq FBpp0077850
NP_001262110.1 RefSeq FBpp0077850
NP_730535.1 RefSeq FBpp0077850

3 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set
Reactome data set  

1 Ec Numbers

Identifier Description

2 Locations

Located On . Primary Identifier
Start End Strand
3L 20425942 20428146 1
3L 20425942 20428146 1

24 Pathways

Identifier Name
154437 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
120472 Signaling by NOTCH4
162718 Signaling by NOTCH1 HD Domain Mutants in Cancer
162388 Signaling by NOTCH1 PEST Domain Mutants in Cancer
163048 Constitutive Signaling by NOTCH1 PEST Domain Mutants
162365 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
162987 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
162349 FBXW7 Mutants and NOTCH1 in Cancer
162508 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
158569 A third proteolytic cleavage releases NICD
162622 Signaling by NOTCH1 in Cancer
118381 Disease
120403 Signaling by NOTCH3
162544 NOTCH2 Activation and Transmission of Signal to the Nucleus
118415 Signaling by ERBB4
144143 Nuclear signaling by ERBB4
120586 Signaling by NOTCH2
120524 Signaling by NOTCH1
120582 Activated NOTCH1 Transmits Signal to the Nucleus
152825 Pre-NOTCH Processing in the Endoplasmic Reticulum
120528 Pre-NOTCH Processing in Golgi
78520 Signaling by NOTCH
120456 Pre-NOTCH Expression and Processing
97910 Signaling Pathways

2 Protein Domains

DB identifier Name Short Name Type
IPR001108 Peptidase A22A, presenilin Peptidase_A22A Family
IPR006639 Presenilin/signal peptide peptidase Preselin/SPP Family

2 Transcripts

DB identifier Gene
FBtr0078192 Psn
FBtr0333479 Psn