Genomics
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5 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0257445 | eIF4G[HMS00762] | Drosophila melanogaster | |
| FBal0261861 | eIF4G[CPTI002576] | Drosophila melanogaster | |
| FBal0134105 | eIF4G[dsRNA.cHa] | Drosophila melanogaster | |
| FBal0180055 | eIF4G[e02087] | Drosophila melanogaster | |
| FBal0209482 | eIF4G[GD7098] | Drosophila melanogaster |
124 Clones
18 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0023213:18 | eIF4G:18 |
| FBgn0023213:16 | eIF4G:16 |
| FBgn0023213:15 | eIF4G:15 |
| FBgn0023213:13 | eIF4G:13 |
| FBgn0023213:12 | eIF4G:12 |
| FBgn0023213:11 | eIF4G:11 |
| FBgn0023213:10 | eIF4G:10 |
| FBgn0023213:9 | eIF4G:9 |
| FBgn0023213:8 | eIF4G:8 |
| FBgn0023213:7 | eIF4G:7 |
| FBgn0023213:6 | eIF4G:6 |
| FBgn0023213:5 | eIF4G:5 |
| FBgn0023213:4 | eIF4G:4 |
| FBgn0023213:2 | eIF4G:2 |
| FBgn0023213:3 | eIF4G:3 |
| FBgn0023213:1 | eIF4G:1 |
| FBgn0023213:14 | eIF4G:14 |
| FBgn0023213:17 | eIF4G:17 |
6 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0089243-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0112904-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0289951-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0089243-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0112904-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0289951-3-prime-utr | Drosophila melanogaster |
Other
76 Pathways
- Processing of Capped Intron-Containing Pre-mRNA,
- Signaling Pathways,
- TOR signaling pathway,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- IRS-mediated signalling,
- RNA Polymerase II Transcription,
- Post-Elongation Processing of the Transcript,
- Cleavage of Growing Transcript in the Termination Region,
- Transport of Mature Transcript to Cytoplasm,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- PI3K Cascade,
- RNA Polymerase II Transcription Elongation,
- Processing of Intronless Pre-mRNAs,
- Insulin receptor mediated signaling,
- Gene Expression,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- S6K1-mediated signalling,
- Nonsense-Mediated Decay,
- 3' -UTR-mediated translational regulation,
- Nonsense Mediated Decay Enhanced by the Exon Junction Complex,
- Formation of a pool of free 40S subunits,
- Metabolism of mRNA,
- Deadenylation-dependent mRNA decay,
- Translation initiation complex formation,
- Transport of the SLBP Dependant Mature mRNA,
- Transport of the SLBP independent Mature mRNA,
- RNA Polymerase II Promoter Escape,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- RNA Polymerase II Transcription Initiation,
- RNA Pol II CTD phosphorylation and interaction with CE,
- Metabolism of proteins,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Post-Elongation Processing of Intronless pre-mRNA,
- Ribosomal scanning and start codon recognition,
- Cap-dependent Translation Initiation,
- Transcription,
- IRS-related events,
- Insulin receptor recycling,
- Insulin signaling pathway,
- Cytokine Signaling in Immune system,
- RNA Polymerase II Transcription Termination,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- IGF1R signaling cascade,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- IRS-related events triggered by IGF1R,
- Metabolism of RNA,
- Formation of RNA Pol II elongation complex,
- Immune System,
- Insulin receptor signalling cascade,
- Formation of the Early Elongation Complex,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- PKB-mediated events,
- Regulation of AMPK activity via LKB1,
- Release of eIF4E,
- ISG15 antiviral mechanism,
- mTOR signalling,
- IRS activation,
- Nonsense Mediated Decay Independent of the Exon Junction Complex,
- S6K1 signalling,
- Deadenylation of mRNA,
- Interferon Signaling,
- RNA Polymerase II Pre-transcription Events,
- DINR-mediated activation,
- mTORC1-mediated signalling,
- Regulation of Rheb GTPase activity by AMPK,
- Processing of Capped Intronless Pre-mRNA,
- Antiviral mechanism by IFN-stimulated genes,
- Elongation arrest and recovery,
- Translation,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Eukaryotic Translation Initiation,
- mRNA Capping,
- SLBP independent Processing of Histone Pre-mRNAs,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- mRNA Processing,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 43839 | NCBI Entrez Gene identifiers | FBgn0023213 |
| 68664 | BioGRID | FBgn0023213 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| TrEMBL data set | http://www.ebi.ac.uk/trembl/ |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
18 Introns
30 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF4G | Increased lipid droplet area | 6.400363835 | 19067489 | |
| Lipid storage | eIF4G | Increased lipid droplet area | 5.320682683 | 19067489 | |
| ERK signaling | eIF4G | ERK activation reduced | weak | 17086199 | |
| Cell size and cell-cycle regulation (1) | eIF4G | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | eIF4G | Increased G1 DNA content, decreased G2 DNA content, decreased G1 cell size | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | eIF4G | none | 1.236 | 16496002 | |
| Cell size and cell-cycle regulation (3) | eIF4G | none | 431 | 16496002 | |
| Microtubule assembly and organization | eIF4G | Abnormal spindle, monopolar spindle, increased number of cells in prometaphase | np | 18463163 | |
| Mutant human huntingtin aggregation | eIF4G | Decreased mutant human huntingtin aggregation | <= -2 | 19789644 | |
| Muscle morphogenesis and function (1) | eIF4G | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (1) | eIF4G | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | eIF4G | Split myofibril, fading Z-line | np | 20220848 | |
| Heat nociception (1) | eIF4G | none | -1.17 | 21074052 | |
| Heat nociception (1) | eIF4G | none | -1.17 | 21074052 | |
| Heart development and function (1) | eIF4G | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | eIF4G | none | -0.655913978494623 | 19520911 | |
| Serratia marcescens infection (1) | eIF4G | none | -0.487179487179487 | 19520911 | |
| Notch pathway regulation (4) | eIF4G | Completely lethal (before pupal) | sp | 19363474 | |
| Notch pathway regulation (4) | eIF4G | Completely lethal (before pupal) | sp | 19363474 | |
| G2-M DNA damage checkpoint regulation (2) | eIF4G | Increased histone H3 phosphorylation with bleocin | 31.11 | with bleocin | 21205937 |
| G2-M DNA damage checkpoint regulation (2) | eIF4G | Increased histone H3 phosphorylation with doxorubicin | 31.4 | with doxorubicin | 21205937 |
| G2-M DNA damage checkpoint regulation (2) | eIF4G | Increased histone H3 phosphorylation with etoposide | 49.62 | with etoposide | 21205937 |
| G2-M DNA damage checkpoint regulation (2) | eIF4G | Increased histone H3 phosphorylation after X-ray exposure | 69.74 | X-ray exposure | 21205937 |
| Adiposity regulation (1) | eIF4G | none | -0.042 | 20074523 | |
| Adiposity regulation (1) | eIF4G | none | 0.103 | 20074523 | |
| RTK-Ras-ERK pathway regulation (1) | eIF4G | Decreased ERK phosphorylation after EGF stimulation | -2.41 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF4G | none | -1.4 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF4G | none | -0.53 | 30 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF4G | none | -1.07 | 10 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF4G | none | 0.35 | 23263283 |
