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Gene : Not3 D. melanogaster

DB identifier  ? FBgn0033029 Secondary Identifier  ? CG8426
Source  FlyBase
  • synonyms:
  • lethal (2) NC136,
  • CNOT3,
  • NOT3,
  • NOT3.5,
  • lethal(2)NC136,
  • CG8426,
  • FBan0008426,
  • l(2)NC136,
  • NOT3/5,
  • FBgn0033029

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10 Alleles

DB identifier Symbol Allele Class Organism
FBal0287044 Not3[Scer\UAS.ORF]   Drosophila melanogaster
FBal0287045 Not3[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0150407 Not3[NC136]   Drosophila melanogaster
FBal0231638 Not3[KK102144]   Drosophila melanogaster
FBal0209860 Not3[GD4068]   Drosophila melanogaster
FBal0159080 Not3[dsRNA.cTa]   Drosophila melanogaster
FBal0263221 Not3[HMS00863]   Drosophila melanogaster
FBal0257483 Not3[HMS00802]   Drosophila melanogaster
FBal0148147 Not3[KG10496]   Drosophila melanogaster
FBal0275995 Not3[NIG.8426R]   Drosophila melanogaster

104 Clones

Secondary Identifier DB identifier
ESG017c.B21.1_C05 FBcl0004517
AT15739 FBcl0022505
AT02015 FBcl0022559
AT04757 FBcl0022567
AT27955 FBcl0022581
EK231355 FBcl0066518
EK272257 FBcl0066550
EK183950 FBcl0066588
EK192832 FBcl0066594
EK180748 FBcl0066598
EK092652 FBcl0066604
EK168125 FBcl0066610
EK267722 FBcl0066614
EK059913 FBcl0066618
EK307412 FBcl0066622
EK140327 FBcl0066628
EK302763 FBcl0066634
EK059916 FBcl0066638
EK032923 FBcl0066642
EK059919 FBcl0066648
EC37603 FBcl0066649
EK160446 FBcl0066652
EK107041 FBcl0066656
EK134062 FBcl0066662
EK070015 FBcl0066668
EK115416 FBcl0066680
EK172919 FBcl0066684
EK240354 FBcl0066688
EK267240 FBcl0066690
EK160606 FBcl0066696

11 Exons

DB identifier Symbol
FBgn0033029:11 l(2)NC136:11
FBgn0033029:10 l(2)NC136:10
FBgn0033029:9 l(2)NC136:9
FBgn0033029:8 l(2)NC136:8
FBgn0033029:7 l(2)NC136:7
FBgn0033029:6 l(2)NC136:6
FBgn0033029:5 l(2)NC136:5
FBgn0033029:4 l(2)NC136:4
FBgn0033029:3 l(2)NC136:3
FBgn0033029:2 l(2)NC136:2
FBgn0033029:1 l(2)NC136:1

2 Transcripts

DB identifier Gene
FBtr0086062 Not3
FBtr0331970 Not3

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0086062-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0331970-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0086062-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0331970-3-prime-utr Drosophila melanogaster

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0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
35501 NCBI Entrez Gene identifiers FBgn0033029
61410 BioGRID FBgn0033029

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1632.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 2035.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1258.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1080.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 2692.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1259.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1635.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1419.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 2277.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1763.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1445.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1478.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1575.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1393.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 2076.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1272.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 2174.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2209.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1278.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1537.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1491.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 2072.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1708.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1538.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1963.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 3334.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2109.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 2536.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 2126.0
FBgn0033029 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 2422.0

10 Introns

DB identifier
Organism . Name
intron_FBgn0033029:11_FBgn0033029:10 Drosophila melanogaster
intron_FBgn0033029:10_FBgn0033029:9 Drosophila melanogaster
intron_FBgn0033029:9_FBgn0033029:8 Drosophila melanogaster
intron_FBgn0033029:8_FBgn0033029:7 Drosophila melanogaster
intron_FBgn0033029:7_FBgn0033029:6 Drosophila melanogaster
intron_FBgn0033029:6_FBgn0033029:5 Drosophila melanogaster
intron_FBgn0033029:5_FBgn0033029:4 Drosophila melanogaster
intron_FBgn0033029:4_FBgn0033029:3 Drosophila melanogaster
intron_FBgn0033029:3_FBgn0033029:2 Drosophila melanogaster
intron_FBgn0033029:3_FBgn0033029:1 Drosophila melanogaster

39 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Not3 Increased lipid droplet area 4.856659322   19067489
Lipid storage Not3 Increased lipid droplet area 9.25013522   19067489
ERK signaling Not3 ERK activation reduced strong   17086199
Imd pathway regulation Not3 Increased Dipt::lacZ protein expression 9   15221030
Hedgehog signaling Not3 Decreased Hedgehog reporter activity -3.23   16311596
Cell size and cell-cycle regulation (1) Not3 Increased G1 cell size, decreased viability sp   16496002
Cell size and cell-cycle regulation (2) Not3 none 1.153   16496002
Cell size and cell-cycle regulation (3) Not3 none 470   16496002
Influenza replication Not3 Decreased Influenza replication -2.5/-1.94   18615016
Microtubule assembly and organization Not3 none np   18463163
Mutant human huntingtin aggregation Not3 Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) Not3 Lethal np   20220848
Muscle morphogenesis and function (1) Not3 Lethal np   20220848
Muscle morphogenesis and function (2) Not3 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) Not3 none np   20220848
Heat nociception (1) Not3 Developmentally lethal 1.41   21074052
Heat nociception (1) Not3 Developmentally lethal 0   21074052
Heart development and function (1) Not3 none 0.8   20371351
Heart development and function (2) Not3 Decreased viability 4.56   20371351
Serratia marcescens infection (1) Not3 none -0.835443037974683   19520911
Notch pathway regulation (4) Not3 Completely lethal (pupal) sp   19363474
Notch pathway regulation (4) Not3 Completely lethal (pupal) sp   19363474
PGN-induced dJNK phosphorylation Not3 Decreased P-JNK protein expression with PGN -2.04 15 min PGN induction 19893628
Notch induced transcription Not3 none -0.79936 without Notch stimulation 20959007
Notch induced transcription Not3 Downregulation of Notch pathway after Notch stimulation -2.9224 N(delta)ecn Notch stimulation 20959007
Notch induced transcription Not3 Downregulation of Notch pathway after Notch stimulation -2.3671 N(delta)ecn Notch stimulation 20959007
Hh pathway regulation Not3 none 0.352917247734991   17903264
Hh pathway regulation Not3 none 0.480654064450409   17903264
Self-renewal and differentiation in neural stem cells Not3 GFP aggregates number, GFP aggregates size, neuroblast larger cell size, neuroblast less large cells, neuroblast cell shape, ganglion mother cell shorter lineages, ganglion mother cell shape, neuroblast loss, neuroblast loss with larger neuroblast cell si sp   21549331
Self-renewal and differentiation in neural stem cells Not3 GFP aggregates number, GFP aggregates size, neuroblast larger cell size, neuroblast less large cells, neuroblast cell shape, ganglion mother cell shorter lineages, ganglion mother cell shape, neuroblast loss, neuroblast loss with larger neuroblast cell si sp   21549331

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