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Gene : Sos D. melanogaster

DB identifier  ? FBgn0001965 Secondary Identifier  ? CG7793
Name  ? Son of sevenless Source  FlyBase
  • synonyms:
  • br25,
  • E(var)189,
  • lethal 25 in the black-reduced region,
  • E(sev)2A,
  • 2.3,
  • EK2-8,
  • l(2)k05224,
  • l(2)k06321,
  • Su(tor)2-2,
  • 34Ea,
  • FBgn0013235,
  • l(2)34Ea,
  • BG:DS00941.4,
  • FBgn0026802,
  • br24,
  • dSos,
  • dme-SOS,
  • CG7793,
  • l(2)Sos,
  • FBan0007793,
  • l(2)br24,
  • Sos1,
  • SOS,
  • lethal 24 in the black-reduced region,
  • son of sevenless,
  • l(2)br25,
  • EY2-3,
  • Son-of-sevenless,
  • FBgn0001965

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94 Alleles

DB identifier Symbol Allele Class Organism
FBal0245478 Sos[JF01186]   Drosophila melanogaster
FBal0245508 Sos[JF01216]   Drosophila melanogaster
FBal0181495 Sos[f05654]   Drosophila melanogaster
FBal0245889 Sos[JF01680]   Drosophila melanogaster
FBal0181496 Sos[f05577]   Drosophila melanogaster
FBal0159741 Sos[KG10074]   Drosophila melanogaster
FBal0065002 Sos[k05705]   Drosophila melanogaster
FBal0061603 Sos[k06321]   Drosophila melanogaster
FBal0061604 Sos[k05224]   Drosophila melanogaster
FBal0029673 Sos[189]   Drosophila melanogaster
FBal0144555 Sos[L013]   Drosophila melanogaster
FBal0034023 Sos[JC2] gain of function allele Drosophila melanogaster
FBal0034022 Sos[+t10]   Drosophila melanogaster
FBal0015973 Sos[34Ea-14] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0045105 Sos[C.hs.sev]   Drosophila melanogaster
FBal0045106 Sos[Cat.hs.sev]   Drosophila melanogaster
FBal0045107 Sos[CatC.hs.sev]   Drosophila melanogaster
FBal0045108 Sos[N.hs.sev]   Drosophila melanogaster
FBal0045109 Sos[NCat.hs.sev]   Drosophila melanogaster
FBal0045110 Sos[NCatC.hs.sev]   Drosophila melanogaster
FBal0045112 Sos[PH.hs.sev]   Drosophila melanogaster
FBal0144545 Sos[L101]   Drosophila melanogaster
FBal0061602 Sos[+t15.1]   Drosophila melanogaster
FBal0030265 Sos[e6C]   Drosophila melanogaster
FBal0015965 Sos[34Ea-6] amorphic allele - genetic evidence Drosophila melanogaster
FBal0120616 Sos[34G]   Drosophila melanogaster
FBal0105103 Sos[e49]   Drosophila melanogaster
FBal0095590 Sos[EY2-3]   Drosophila melanogaster
FBal0030260 Sos[x122] loss of function allele, amorphic allele - genetic evidence Drosophila melanogaster
FBal0015975 Sos[34Ea-16] hypomorphic allele - genetic evidence Drosophila melanogaster

25 Clones

Secondary Identifier DB identifier
EK199022 FBcl0081500
EK181651 FBcl0081536
EK252746 FBcl0081560
EK170545 FBcl0081566
GH01796 FBcl0111307
GH20468 FBcl0111333
LP02504 FBcl0182688
RE44885 FBcl0204309
RE20488 FBcl0204313
RE23605 FBcl0204314
SD03912 FBcl0291365
SD24027 FBcl0291368
SD11090 FBcl0291369
SD01193 FBcl0291378
EC051246 FBcl0301251
EC051829 FBcl0301252
EC053737 FBcl0301250
55068 FBcl0402816
54295 FBcl0402766
71059 FBcl0402778
17193 FBcl0402824
15684 FBcl0402831
56984 FBcl0402836
145126 FBcl0402843
RP003467647 FBcl0574379

7 Exons

DB identifier Symbol
FBgn0001965:1 Sos:1
FBgn0001965:2 Sos:2
FBgn0001965:3 Sos:3
FBgn0001965:4 Sos:4
FBgn0001965:5 Sos:5
FBgn0001965:6 Sos:6
FBgn0001965:7 Sos:7

1 Transcripts

DB identifier Gene
FBtr0080541 Sos

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0080541-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0080541-3-prime-utr Drosophila melanogaster

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Other

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
34790 NCBI Entrez Gene identifiers FBgn0001965
60823 BioGRID FBgn0001965

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 908.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1245.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 846.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 907.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1321.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 546.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1250.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1215.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 352.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1256.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1301.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1116.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1090.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1460.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 925.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 817.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1409.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 819.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1348.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 724.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1051.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1091.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 886.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1064.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 934.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2169.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 890.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1317.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 877.0
FBgn0001965 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1134.0

6 Introns

DB identifier
Organism . Name
intron_FBgn0001965:1_FBgn0001965:2 Drosophila melanogaster
intron_FBgn0001965:2_FBgn0001965:3 Drosophila melanogaster
intron_FBgn0001965:3_FBgn0001965:4 Drosophila melanogaster
intron_FBgn0001965:4_FBgn0001965:5 Drosophila melanogaster
intron_FBgn0001965:5_FBgn0001965:6 Drosophila melanogaster
intron_FBgn0001965:6_FBgn0001965:7 Drosophila melanogaster

30 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation Sos Decreased cell size -4.09   19216764
Lipid storage Sos none 1.703064521   19067489
Lipid storage Sos none 0.602167359   19067489
Insect dengue virus infection Sos Inhibition of dengue virus propagation 2 (0.0047)   19396146
ERK signaling Sos ERK activation reduced strong   17086199
Cell morphology Sos Morphology np   14527345
Wnt signaling Sos Increased Wnt reporter activity 3.7   15817814
Constitutive protein secretion and Golgi organization (1) Sos Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Sos none sp   16496002
Combinatorial effect with methyl methanesulphonate (2) Sos Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) Sos Lethal np   20220848
Muscle morphogenesis and function (1) Sos Lethal np   20220848
Muscle morphogenesis and function (2) Sos Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Heat nociception (1) Sos none 1.32   21074052
Heart development and function (1) Sos none 1   20371351
Serratia marcescens infection (1) Sos none 1.3125   19520911
Notch pathway regulation (4) Sos Gain of bristles, colour defects, bristle morphology defects, notum malformation death sp   19363474
Notch pathway regulation (4) Sos Bristle morphology defects, notum malformation death sp   19363474
Notch induced transcription Sos none 1.7729 without Notch stimulation 20959007
Notch induced transcription Sos Upregulation of Notch pathway after Notch stimulation 3.6044 N(delta)ecn Notch stimulation 20959007
Notch induced transcription Sos none 0.34124 N(delta)ecn Notch stimulation 20959007
Notch pathway regulation (1) Sos Upregulation of Notch pathway np   20493818
Adiposity regulation (1) Sos none -0.251   20074523
RTK-Ras-ERK pathway regulation (1) Sos Decreased ERK phosphorylation after EGF stimulation -3.67 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Sos Decreased ERK phosphorylation after EGF stimulation -3.17 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Sos Decreased ERK phosphorylation after sSpitz and EGF stimulation -2.48 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Sos none -1.44 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation Sos none 2.96   23263283
Immune deficiency pathway regulation Sos Upregulation of IMD pathway after E.coli stimulation 4.18   21297578
Glycosylation regulation (4) Sos Increased alpha1,3-fucose Chp glycosylation, increased alpha1,6-fucose Chp glycosylation, increased mannose Chp glycosylation sp   21203496

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