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Gene : Cdc27 D. melanogaster

DB identifier  ? FBgn0012058 Secondary Identifier  ? CG8610
Name  ? Cell division cycle 27 ortholog Source  FlyBase
  • synonyms:
  • FBan0008610,
  • l(3)L7123,
  • Makos,
  • CDC27,
  • mks,
  • Dmcdc27,
  • CDC27Dm,
  • APC3,
  • FBgn0024570,
  • CG8610,
  • FBgn0012058

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12 Alleles

DB identifier Symbol Allele Class Organism
FBal0245325 Cdc27[HM04024]   Drosophila melanogaster
FBal0087027 Cdc27[L7123]   Drosophila melanogaster
FBal0100461 Cdc27[S092309] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0196941 Cdc27[+t6.2]   Drosophila melanogaster
FBal0264954 Cdc27[E45]   Drosophila melanogaster
FBal0213191 Cdc27[Ubi-p63E.T:Avic\GFP-m6]   Drosophila melanogaster
FBal0213192 Cdc27[C.T:Avic\GFP]   Drosophila melanogaster
FBal0213194 Cdc27[dsRNA.cHa]   Drosophila melanogaster
FBal0213193 Cdc27[unspecified]   Drosophila melanogaster
FBal0191442 Cdc27[DeltaBam.t6.2]   Drosophila melanogaster
FBal0287453 Cdc27[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0206538 Cdc27[GD13986]   Drosophila melanogaster

24 Clones

Secondary Identifier DB identifier
AT21788 FBcl0023659
AT23470 FBcl0023667
AT01224 FBcl0023671
AT03457 FBcl0023693
EP19301 FBcl0081501
GH12137 FBcl0111275
GH23045 FBcl0111279
EK190126 FBcl0124748
EK063819 FBcl0125262
EK232060 FBcl0125548
EK243733 FBcl0125738
LD12661 FBcl0154038
RE35730 FBcl0204224
RE10358 FBcl0204229
RE34522 FBcl0204257
RE64159 FBcl0204269
RE39625 FBcl0204276
SD01880 FBcl0283951
CK01.61B.E9 FBcl0395222
DPiM_LD12661 FBcl0738547
106515 FBcl0476652
101843 FBcl0476754
54367 FBcl0476792
62999 FBcl0476816

4 Exons

DB identifier Symbol
FBgn0012058:1 Cdc27:1
FBgn0012058:4 Cdc27:4
FBgn0012058:3 Cdc27:3
FBgn0012058:2 Cdc27:2

2 Transcripts

DB identifier Gene
FBtr0333369 Cdc27
FBtr0076890 Cdc27

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0076890-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0333369-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076890-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0333369-3-prime-utr Drosophila melanogaster

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53 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
38798 NCBI Entrez Gene identifiers FBgn0012058
64241 BioGRID FBgn0012058

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 611.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 622.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 503.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 597.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 700.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 355.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 550.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 668.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 276.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 647.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 677.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 398.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 416.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 577.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 545.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 551.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 550.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 501.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 690.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 472.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 685.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 646.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 523.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 604.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 520.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1829.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 799.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1014.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 789.0
FBgn0012058 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 719.0

3 Introns

DB identifier
Organism . Name
intron_FBgn0012058:4_FBgn0012058:3 Drosophila melanogaster
intron_FBgn0012058:3_FBgn0012058:1 Drosophila melanogaster
intron_FBgn0012058:3_FBgn0012058:2 Drosophila melanogaster

29 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Cdc27 none -0.784267238   19067489
Lipid storage Cdc27 none 0.394458279   19067489
ERK signaling Cdc27 ERK activation reduced strong   17086199
Cell morphology Cdc27 Morphology np   14527345
Cytokinesis regulation Cdc27 Binucleate cells with microtubule extensions weak   15547975
Intracellular Listeria monocytogenes infection Cdc27 Decreased GFP protein expression strong   16020693
L. monocytogenes infection Cdc27 Fewer infected cells **   16157870
Mycobacterial infection (1) - M. fortuitum infection Cdc27 Decreased M. fortuitum intracellular infection 7.9 measurement after 3 days 16020694
Mycobacterial infection (2) - E. coli phagocytosis Cdc27 Decreased E. coli phagocytosis np   16020694
Constitutive protein secretion and Golgi organization (1) Cdc27 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Cdc27 Decreased G1 cell size, decreased viability sp   16496002
Cell size and cell-cycle regulation (2) Cdc27 none 1.244   16496002
Cell size and cell-cycle regulation (3) Cdc27 none 450   16496002
Microtubule assembly and organization Cdc27 Centrosome position defects, abnormal spindle, chromosome alignment defect, increased number of cells in prometaphase np   18463163
Muscle morphogenesis and function (1) Cdc27 Weak flyer np   20220848
Muscle morphogenesis and function (1) Cdc27 Lethal np   20220848
Heat nociception (1) Cdc27 none -1.17   21074052
Heart development and function (1) Cdc27 none 1   20371351
Serratia marcescens infection (1) Cdc27 none 0.63076923076923   19520911
Notch pathway regulation (4) Cdc27 Notum malformation death 9   19363474
Notch pathway regulation (4) Cdc27 Notum malformation death 8   19363474
Self-renewal and differentiation in neural stem cells Cdc27 GFP aggregates number, GFP aggregates size, neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underprolifer sp   21549331
Adiposity regulation (1) Cdc27 none -0.311   20074523
RTK-Ras-ERK pathway regulation (1) Cdc27 Increased ERK phosphorylation after EGF stimulation 6.12 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Cdc27 Decreased ERK phosphorylation after EGF stimulation -6.57 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Cdc27 Decreased ERK phosphorylation after sSpitz and EGF stimulation -2.16 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Cdc27 Decreased ERK phosphorylation after sSpitz and EGF stimulation -1.6 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation Cdc27 none 0.73   23263283
Glycosylation regulation (1) Cdc27 none sp   21203496

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