Genomics
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Regulatory Regions Displayer
32 Alleles
61 Clones
7 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0026317:1 | Tsc1:1 |
| FBgn0026317:2 | Tsc1:2 |
| FBgn0026317:3 | Tsc1:3 |
| FBgn0026317:4 | Tsc1:4 |
| FBgn0026317:5 | Tsc1:5 |
| FBgn0026317:6 | Tsc1:6 |
| FBgn0026317:7 | Tsc1:7 |
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0084546-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0084546-3-prime-utr | Drosophila melanogaster |
Other
23 Pathways
- PI3K Cascade,
- PKB-mediated events,
- Activation of PKB,
- Regulation of Rheb GTPase activity by AMPK,
- IRS-related events triggered by IGF1R,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- IRS-related events,
- TOR signaling pathway,
- Signaling Pathways,
- Insulin receptor recycling,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- IGF1R signaling cascade,
- Insulin receptor signalling cascade,
- Insulin receptor mediated signaling,
- DINR-mediated activation,
- mTORC1-mediated signalling,
- IRS-mediated signalling,
- Regulation of AMPK activity via LKB1,
- mTOR signalling,
- Release of eIF4E,
- IRS activation,
- Inhibition of TSC complex formation by PKB,
- Insulin signaling pathway
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 42862 | NCBI Entrez Gene identifiers | FBgn0026317 |
| 67795 | BioGRID | FBgn0026317 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| TrEMBL data set | http://www.ebi.ac.uk/trembl/ |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
6 Introns
27 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Cell size regulation | Tsc1 | none | -0.1 | 19216764 | |
| Lipid storage | Tsc1 | Decreased lipid droplet area | -2.444622082 | 19067489 | |
| Lipid storage | Tsc1 | Decreased lipid droplet area | -1.965462032 | 19067489 | |
| Chlamydia caviae infection | Tsc1 | Decreased Chlamydia caviae infection | np | 17967059 | |
| Cell size and cell-cycle regulation (1) | Tsc1 | Decreased G1 DNA content, increased cytokinesis | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | Tsc1 | none | 1.307 | 16496002 | |
| Cell size and cell-cycle regulation (3) | Tsc1 | none | 449 | 16496002 | |
| Cell size and cell-cycle regulation (4) | Tsc1 | Increased number of mitotic cells | 0.9 | 16496002 | |
| Hypoxia signaling | Tsc1 | Hypoxia-induced translation inhibition is reduced | np | 18653470 | |
| Combinatorial effect with methyl methanesulphonate (1) | Tsc1 | none | sp | 19543366 | |
| Combinatorial effect with methyl methanesulphonate (2) | Tsc1 | Synthetic lethal with methyl methanesulphonate | sp | 19543366 | |
| Muscle morphogenesis and function (1) | Tsc1 | none | np | 20220848 | |
| Heat nociception (1) | Tsc1 | none | -1.17 | 21074052 | |
| Heart development and function (1) | Tsc1 | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | Tsc1 | none | 0.716666666666666 | 19520911 | |
| Notch pathway regulation (4) | Tsc1 | Gain of bristles, notum malformation migration | sp | 19363474 | |
| Notch induced transcription | Tsc1 | none | 0.79676 | N(delta)ecn Notch stimulation | 20959007 |
| Notch induced transcription | Tsc1 | Upregulation of Notch pathway after Notch stimulation | 2.8669 | N(delta)ecn Notch stimulation | 20959007 |
| Notch induced transcription | Tsc1 | none | -1.6425 | without Notch stimulation | 20959007 |
| Akt-TOR pathway negative feedback regulation | Tsc1 | Decreased dAkt phosphorylation after insulin stimulation | -4.4 | 10 min insulin stimulation | 20585550 |
| Adiposity regulation (1) | Tsc1 | Increased triglyceride expression | 0.2 | 20074523 | |
| Adiposity regulation (2) | Tsc1 | Decreased triglyceride expression | -0.295 | 20074523 | |
| Adiposity regulation (3) | Tsc1 | none | -0.007 | 20074523 | |
| Adiposity regulation (4) | Tsc1 | none | -0.011 | 20074523 | |
| Adiposity regulation (5) | Tsc1 | Decreased triglyceride expression | -0.544 | 20074523 | |
| Hippo pathway regulation | Tsc1 | none | -0.5 | 23263283 | |
| Glycosylation regulation (1) | Tsc1 | none | sp | 21203496 |
