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Gene : Tsc1 D. melanogaster

DB identifier  ? FBgn0026317 Secondary Identifier  ? CG6147
Name  ? Tsc1 Source  FlyBase
  • synonyms:
  • hamartin,
  • FBan0006147,
  • dTSC-1,
  • Tuberous Sclerosis 1,
  • CG6147,
  • TTuberous Sclerosis Complex 1,
  • TSC1,
  • dTSC,
  • FBgn0026317,
  • rocky,
  • TSC,
  • dTSC1,
  • Tuberous Sclerosis Complex 1,
  • unnamed,
  • jolly green giant

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32 Alleles

DB identifier Symbol Allele Class Organism
FBal0245554 Tsc1[JF01262]   Drosophila melanogaster
FBal0245748 Tsc1[JF01484]   Drosophila melanogaster
FBal0159590 Tsc1[f01910]   Drosophila melanogaster
FBal0123965 Tsc1[Q87X]   Drosophila melanogaster
FBal0123970 Tsc1[+t4.7]   Drosophila melanogaster
FBal0123968 Tsc1[29]   Drosophila melanogaster
FBal0159592 Tsc1[2G3]   Drosophila melanogaster
FBal0159591 Tsc1[2X1]   Drosophila melanogaster
FBal0141337 Tsc1[a.cRa]   Drosophila melanogaster
FBal0175772 Tsc1[L115R]   Drosophila melanogaster
FBal0141336 Tsc1[cRa]   Drosophila melanogaster
FBal0123969 Tsc1[12]   Drosophila melanogaster
FBal0150576 Tsc1[dsRNA.cGa]   Drosophila melanogaster
FBal0123966 Tsc1[Q600X]   Drosophila melanogaster
FBal0123959 Tsc1[unspecified]   Drosophila melanogaster
FBal0123960 Tsc1[W243X]   Drosophila melanogaster
FBal0159593 Tsc1[1A2]   Drosophila melanogaster
FBal0123964 Tsc1[R453X]   Drosophila melanogaster
FBal0262503 Tsc1[GL00012]   Drosophila melanogaster
FBal0123967 Tsc1[Act5C.T:Hsap\MYC]   Drosophila melanogaster
FBal0150578 Tsc1[MtnA.T:Hsap\MYC]   Drosophila melanogaster
FBal0123963 Tsc1[Scer\UAS.cGa]   Drosophila melanogaster
FBal0123962 Tsc1[Scer\UAS.cPa]   Drosophila melanogaster
FBal0123961 Tsc1[Scer\UAS.cTa]   Drosophila melanogaster
FBal0150577 Tsc1[Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0286847 Tsc1[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286848 Tsc1[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0193740 Tsc1[IQ69]   Drosophila melanogaster
FBal0208859 Tsc1[GD11836]   Drosophila melanogaster
FBal0268648 Tsc1[1149]   Drosophila melanogaster

61 Clones

Secondary Identifier DB identifier
DPiM_LD23779 FBcl0740931
AT16928 FBcl0028193
AT22785 FBcl0028195
AT06827 FBcl0028199
EN16733 FBcl0097461
GH21863 FBcl0118465
GH09624 FBcl0118515
GH15432 FBcl0118517
EK051446 FBcl0119764
EK144532 FBcl0119776
EK266328 FBcl0119816
LD11221 FBcl0156611
LD34503 FBcl0170378
LD32376 FBcl0170380
LD38116 FBcl0170381
LD23779 FBcl0170387
LD24327 FBcl0170390
LD29419 FBcl0170394
LD33889 FBcl0170399
LD25933 FBcl0170498
RE69787 FBcl0214027
RE49066 FBcl0214035
RE28589 FBcl0214048
RE37537 FBcl0214050
RE06816 FBcl0214053
RE55685 FBcl0214059
SD05268 FBcl0286197
CK01.7D.D1 FBcl0421518
571375 FBcl0421564
RP003510468 FBcl0560755

7 Exons

DB identifier Symbol
FBgn0026317:1 Tsc1:1
FBgn0026317:2 Tsc1:2
FBgn0026317:3 Tsc1:3
FBgn0026317:4 Tsc1:4
FBgn0026317:5 Tsc1:5
FBgn0026317:6 Tsc1:6
FBgn0026317:7 Tsc1:7

1 Transcripts

DB identifier Gene
FBtr0084546 Tsc1

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0084546-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0084546-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
42862 NCBI Entrez Gene identifiers FBgn0026317
67795 BioGRID FBgn0026317

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 814.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 939.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 944.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1071.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1015.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 924.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1043.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 614.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 394.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1243.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1186.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 455.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 718.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 440.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 607.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 645.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 748.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 955.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1007.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 587.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 733.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 940.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 984.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 669.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 344.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2476.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2685.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 849.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 810.0
FBgn0026317 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 515.0

6 Introns

DB identifier
Organism . Name
intron_FBgn0026317:1_FBgn0026317:2 Drosophila melanogaster
intron_FBgn0026317:2_FBgn0026317:3 Drosophila melanogaster
intron_FBgn0026317:3_FBgn0026317:4 Drosophila melanogaster
intron_FBgn0026317:4_FBgn0026317:5 Drosophila melanogaster
intron_FBgn0026317:5_FBgn0026317:6 Drosophila melanogaster
intron_FBgn0026317:6_FBgn0026317:7 Drosophila melanogaster

27 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation Tsc1 none -0.1   19216764
Lipid storage Tsc1 Decreased lipid droplet area -2.444622082   19067489
Lipid storage Tsc1 Decreased lipid droplet area -1.965462032   19067489
Chlamydia caviae infection Tsc1 Decreased Chlamydia caviae infection np   17967059
Cell size and cell-cycle regulation (1) Tsc1 Decreased G1 DNA content, increased cytokinesis sp   16496002
Cell size and cell-cycle regulation (2) Tsc1 none 1.307   16496002
Cell size and cell-cycle regulation (3) Tsc1 none 449   16496002
Cell size and cell-cycle regulation (4) Tsc1 Increased number of mitotic cells 0.9   16496002
Hypoxia signaling Tsc1 Hypoxia-induced translation inhibition is reduced np   18653470
Combinatorial effect with methyl methanesulphonate (1) Tsc1 none sp   19543366
Combinatorial effect with methyl methanesulphonate (2) Tsc1 Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) Tsc1 none np   20220848
Heat nociception (1) Tsc1 none -1.17   21074052
Heart development and function (1) Tsc1 none 1   20371351
Serratia marcescens infection (1) Tsc1 none 0.716666666666666   19520911
Notch pathway regulation (4) Tsc1 Gain of bristles, notum malformation migration sp   19363474
Notch induced transcription Tsc1 none 0.79676 N(delta)ecn Notch stimulation 20959007
Notch induced transcription Tsc1 Upregulation of Notch pathway after Notch stimulation 2.8669 N(delta)ecn Notch stimulation 20959007
Notch induced transcription Tsc1 none -1.6425 without Notch stimulation 20959007
Akt-TOR pathway negative feedback regulation Tsc1 Decreased dAkt phosphorylation after insulin stimulation -4.4 10 min insulin stimulation 20585550
Adiposity regulation (1) Tsc1 Increased triglyceride expression 0.2   20074523
Adiposity regulation (2) Tsc1 Decreased triglyceride expression -0.295   20074523
Adiposity regulation (3) Tsc1 none -0.007   20074523
Adiposity regulation (4) Tsc1 none -0.011   20074523
Adiposity regulation (5) Tsc1 Decreased triglyceride expression -0.544   20074523
Hippo pathway regulation Tsc1 none -0.5   23263283
Glycosylation regulation (1) Tsc1 none sp   21203496

0 Submissions