Genomics
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11 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0257182 | Ubi-p63E[HMS00284] | Drosophila melanogaster | |
| FBal0181104 | Ubi-p63E[e03111] | Drosophila melanogaster | |
| FBal0181105 | Ubi-p63E[e02712] | Drosophila melanogaster | |
| FBal0181106 | Ubi-p63E[c04861] | Drosophila melanogaster | |
| FBal0159570 | Ubi-p63E[EY07341] | Drosophila melanogaster | |
| FBal0147334 | Ubi-p63E[unspecified] | Drosophila melanogaster | |
| FBal0135769 | Ubi-p63E[dsRNA.cRa] | Drosophila melanogaster | |
| FBal0197697 | Ubi-p63E[dsRNA.cMa] | Drosophila melanogaster | |
| FBal0101526 | Ubi-p63E[hs.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0141333 | Ubi-p63E[MtnA.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0236232 | Ubi-p63E[KK109327] | Drosophila melanogaster |
89 Clones
7 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0003943:7 | Ubi-p63E:7 |
| FBgn0003943:2 | Ubi-p63E:2 |
| FBgn0003943:3 | Ubi-p63E:3 |
| FBgn0003943:1 | Ubi-p63E:1 |
| FBgn0003943:6 | Ubi-p63E:6 |
| FBgn0003943:5 | Ubi-p63E:5 |
| FBgn0003943:4 | Ubi-p63E:4 |
4 Transcripts
| DB identifier | Gene |
|---|---|
| FBtr0073178 | Ubi-p63E |
| FBtr0073179 | Ubi-p63E |
| FBtr0073177 | Ubi-p63E |
| FBtr0333142 | Ubi-p63E |
8 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0073177-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0073179-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0073178-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0333142-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0073177-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0073179-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0073178-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0333142-3-prime-utr | Drosophila melanogaster |
Other
187 Pathways
- Mitotic G1-G1/S phases,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription,
- Gene Expression,
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- Signaling by NGF,
- Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor,
- Activated TLR4 signalling,
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant,
- Toll Like Receptor 4 (TLR4) Cascade,
- Negative regulation of FGFR signaling,
- MyD88:Mal cascade initiated on plasma membrane,
- Mitotic Spindle Checkpoint,
- Cell Cycle, Mitotic,
- Signaling by FGFR in disease,
- Toll Like Receptor 5 (TLR5) Cascade,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- Spry regulation of FGF signaling,
- Developmental Biology,
- Signaling by ERBB2,
- Adaptive Immune System,
- SCF-beta-TrCP mediated degradation of Emi1,
- Signaling Pathways,
- Signaling by NOTCH1 PEST Domain Mutants in Cancer,
- Toll Like Receptor 2 (TLR2) Cascade,
- Toll Like Receptor 7/8 (TLR7/8) Cascade,
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer,
- Mitotic Anaphase,
- MyD88 cascade initiated on plasma membrane,
- G1/S DNA Damage Checkpoints,
- Signaling by FGFR,
- Removal of licensing factors from origins,
- Disease,
- Fanconi Anemia pathway,
- DNA Replication Pre-Initiation,
- Cell Cycle Checkpoints,
- p53-Independent DNA Damage Response,
- Fc epsilon receptor (FCERI) signaling,
- Activation of NF-kappaB in B Cells,
- DNA Replication,
- NGF signalling via TRKA from the plasma membrane,
- GAB1 signalosome,
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants,
- Innate Immune System,
- Signaling by NOTCH2,
- Separation of Sister Chromatids,
- Signaling by constitutively active EGFR,
- Toll Like Receptor TLR1:TLR2 Cascade,
- M/G1 Transition,
- APC/C:Cdc20 mediated degradation of Securin,
- Pre-NOTCH Processing in the Endoplasmic Reticulum,
- DNA Repair,
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation,
- APC-Cdc20 mediated degradation of Nek2A,
- SMAD2/3 MH2 Domain Mutants in Cancer,
- Class I MHC mediated antigen processing & presentation,
- Homologous Recombination Repair,
- Double-Strand Break Repair,
- Senescence-Associated Secretory Phenotype (SASP),
- DAP12 signaling,
- Cyclin D associated events in G1,
- Signaling by Wnt,
- Signaling by NODAL,
- TGFBR1 LBD Mutants in Cancer,
- Regulation of Hypoxia-inducible Factor (HIF) by Oxygen,
- TGFBR2 Kinase Domain Mutants in Cancer,
- Cyclin A/B1 associated events during G2/M transition,
- Homologous recombination repair of replication-independent double-strand breaks,
- Loss of Function of TGFBR2 in Cancer,
- NOTCH2 Activation and Transmission of Signal to the Nucleus,
- Downstream Signaling Events Of B Cell Receptor (BCR),
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- Constitutive Signaling by NOTCH1 HD Domain Mutants,
- Downregulation of ERBB4 signaling,
- Role of LAT2/NTAL/LAB on calcium mobilization,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- Generic Transcription Pathway,
- TRIF-mediated TLR3/TLR4 signaling,
- G2/M Transition,
- MyD88 dependent cascade initiated on endosome,
- Toll Like Receptor 10 (TLR10) Cascade,
- Signaling by Activin,
- Constitutive Signaling by NOTCH1 PEST Domain Mutants,
- Activated NOTCH1 Transmits Signal to the Nucleus,
- Signaling by TGF-beta Receptor Complex in Cancer,
- Signaling by NOTCH3,
- Orc1 removal from chromatin,
- p75NTR signals via NF-kB,
- Synthesis of DNA,
- Signaling by EGFR in Cancer,
- ER-Phagosome pathway,
- EGFR downregulation,
- IRAK2 mediated activation of TAK1 complex,
- Pre-NOTCH Expression and Processing,
- Regulation of activated PAK-2p34 by proteasome mediated degradation,
- Degradation of beta-catenin by the destruction complex,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- FBXW7 Mutants and NOTCH1 in Cancer,
- Signaling by NOTCH1 in Cancer,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- Signaling by TGF-beta Receptor Complex,
- Cross-presentation of soluble exogenous antigens (endosomes),
- p75 NTR receptor-mediated signalling,
- Endosomal Sorting Complex Required For Transport (ESCRT),
- Autodegradation of Cdh1 by Cdh1:APC/C,
- Regulation of DNA replication,
- Regulation of mitotic cell cycle,
- Signaling by ERBB4,
- DAP12 interactions,
- Cell Cycle,
- TGFBR2 MSI Frameshift Mutants in Cancer,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- Mitotic G2-G2/M phases,
- Downstream signaling of activated FGFR,
- PI-3K cascade,
- SMAD2/3 Phosphorylation Motif Mutants in Cancer,
- Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant,
- Apoptosis,
- Downregulation of SMAD2/3:SMAD4 transcriptional activity,
- SCF(Skp2)-mediated degradation of p27/p21,
- Regulation of PLK1 Activity at G2/M Transition,
- G1/S Transition,
- TRAF6 mediated induction of TAK1 complex,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- TRAF6 Mediated Induction of proinflammatory cytokines,
- NOTCH1 Intracellular Domain Regulates Transcription,
- G2/M DNA replication checkpoint,
- TGFBR1 KD Mutants in Cancer,
- CDK-mediated phosphorylation and removal of Cdc6,
- Membrane Trafficking,
- PI3K events in ERBB4 signaling,
- PI3K/AKT Signaling in Cancer,
- B Cell Activation,
- Cyclin E associated events during G1/S transition,
- Toll-Like Receptors Cascades,
- Loss of Function of TGFBR1 in Cancer,
- Beta-catenin phosphorylation cascade,
- Loss of Function of SMAD4 in Cancer,
- Signaling by EGFR,
- Mitotic Metaphase and Anaphase,
- PI3K events in ERBB2 signaling,
- Cellular Senescence,
- TGF-beta receptor signaling activates SMADs,
- Signaling by NOTCH,
- Downstream signal transduction,
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer,
- Signaling by SCF-KIT,
- MyD88-independent cascade,
- Signaling by NOTCH4,
- Toll Like Receptor TLR6:TLR2 Cascade,
- Signaling by NOTCH1 HD Domain Mutants in Cancer,
- Cyclin A:Cdk2-associated events at S phase entry,
- Cellular response to hypoxia,
- ATM mediated response to DNA double-strand break,
- Signaling by PDGF,
- Mitotic M-M/G1 phases,
- Switching of origins to a post-replicative state,
- PI3K/AKT activation,
- Amplification of signal from the kinetochores,
- Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha,
- Downregulation of ERBB2:ERBB3 signaling,
- Immune System,
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation,
- Toll Like Receptor 3 (TLR3) Cascade,
- Toll Like Receptor 9 (TLR9) Cascade,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- NF-kB is activated and signals survival,
- M Phase,
- Downregulation of TGF-beta receptor signaling,
- APC/C-mediated degradation of cell cycle proteins,
- Antigen processing-Cross presentation,
- Cellular responses to stress,
- Antigen processing: Ubiquitination & Proteasome degradation,
- Pre-NOTCH Processing in Golgi,
- Loss of Function of SMAD2/3 in Cancer,
- Polo-like kinase mediated events,
- Regulation of APC/C activators between G1/S and early anaphase,
- G2/M Checkpoints,
- p53-Independent G1/S DNA damage checkpoint,
- Circadian Clock,
- S Phase,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Signaling by NOTCH1,
- G1 Phase,
- G2/M DNA damage checkpoint,
- Regulation of Apoptosis,
- SMAD4 MH2 Domain Mutants in Cancer
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 38456 | NCBI Entrez Gene identifiers | FBgn0003943 |
| 63944 | BioGRID | FBgn0003943 |
10 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
5 Introns
24 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | Ubi-p63E | none | -0.280638698 | 19067489 | |
| Lipid storage | Ubi-p63E | none | -1.882014772 | 19067489 | |
| Chlamydia caviae infection | Ubi-p63E | Decreased Chlamydia caviae infection | np | 17967059 | |
| Drosophila C virus infection | Ubi-p63E | Drosophila C virus replication down | np | 17040126 | |
| E. coli / S. aureus infection | Ubi-p63E | Cell death | np | 11912489 | |
| Cytokinesis regulation | Ubi-p63E | Binucleate cells with decreased viability | weak | 15547975 | |
| Intracellular Listeria monocytogenes infection | Ubi-p63E | Decreased GFP protein expression | strong | 16020693 | |
| Hedgehog signaling | Ubi-p63E | Decreased Hedgehog reporter activity | -3.8 | 16311596 | |
| Hedgehog signaling | Ubi-p63E | Decreased Hedgehog reporter activity | -4.44 | 16311596 | |
| Mycobacterial infection (1) - M. fortuitum infection | Ubi-p63E | Decreased M. fortuitum intracellular infection | 11.8 | measurement after 3 days | 16020694 |
| Mycobacterial infection (2) - E. coli phagocytosis | Ubi-p63E | Decreased E. coli phagocytosis | np | 16020694 | |
| Cell size and cell-cycle regulation (1) | Ubi-p63E | Decreased G1 DNA content, decreased G1 cell size, decreased viability, increased cytokinesis | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | Ubi-p63E | Decreased viability | 0.28 | 16496002 | |
| Cell size and cell-cycle regulation (3) | Ubi-p63E | Decreased cell number | 26 | 16496002 | |
| Cell size and cell-cycle regulation (4) | Ubi-p63E | none | below threshold | 16496002 | |
| Candida albicans phagocytosis (1) | Ubi-p63E | Decreased Candida albicans phagocytosis | np | 16336044 | |
| Candida albicans phagocytosis (2) | Ubi-p63E | Decreased Escherichia coli phagocytosis | 24 | 16336044 | |
| Candida albicans phagocytosis (3) | Ubi-p63E | Decreased latex beads phagocytosis | 33 | 16336044 | |
| Mutant human huntingtin aggregation | Ubi-p63E | Decreased mutant human huntingtin aggregation | <= -2 | 19789644 | |
| RTK-Ras-ERK pathway regulation (1) | Ubi-p63E | none | -0.2 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | Ubi-p63E | Decreased ERK phosphorylation after EGF stimulation | -7.25 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Ubi-p63E | Decreased ERK phosphorylation after sSpitz and EGF stimulation | -7.57 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Ubi-p63E | Decreased ERK phosphorylation after sSpitz and EGF stimulation | -5.57 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | Ubi-p63E | none | 0.38 | 23263283 |
