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Gene : Tak1 D. melanogaster

DB identifier  ? FBgn0026323 Secondary Identifier  ? CG18492
Name  ? TGF-beta activated kinase 1 Source  FlyBase
  • synonyms:
  • TGF-beta activated-kinase 1,
  • dTAK-1,
  • CG1388,
  • TAK,
  • DmTak1,
  • CG18492,
  • TGF beta-activated kinase 1,
  • D-TAK,
  • TAK1,
  • transforming growth factor-beta-activated kinase 1,
  • DTAK1,
  • FBan0018492,
  • TAK-1,
  • DTak,
  • TGFbeta-activated kinase 1,
  • FBgn0042230,
  • Tak 1,
  • FBgn0031120,
  • TGF-beta activated kinase 1,
  • D10,
  • FBgn0026323

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30 Alleles

DB identifier Symbol Allele Class Organism
FBal0284405 Tak1[Scer\UAS.cUa]   Drosophila melanogaster
FBal0257181 Tak1[HMS00282]   Drosophila melanogaster
FBal0245656 Tak1[JF01384]   Drosophila melanogaster
FBal0245754 Tak1[JF01492]   Drosophila melanogaster
FBal0138376 Tak1[NIG.1388R]   Drosophila melanogaster
FBal0126476 Tak1[+t15]   Drosophila melanogaster
FBal0126475 Tak1[1]   Drosophila melanogaster
FBal0134137 Tak1[2527] amorphic allele - genetic evidence Drosophila melanogaster
FBal0126471 Tak1[unspecified]   Drosophila melanogaster
FBal0126472 Tak1[4]   Drosophila melanogaster
FBal0126473 Tak1[3]   Drosophila melanogaster
FBal0190598 Tak1[G14]   Drosophila melanogaster
FBal0147365 Tak1[dsRNA.cBa]   Drosophila melanogaster
FBal0123979 Tak1[dsRNA.cNa]   Drosophila melanogaster
FBal0159683 Tak1[dsRNA.cSb]   Drosophila melanogaster
FBal0147366 Tak1[dsRNA.cCa]   Drosophila melanogaster
FBal0144493 Tak1[dsRNA.cSa]   Drosophila melanogaster
FBal0126474 Tak1[2]   Drosophila melanogaster
FBal0262540 Tak1[GL00052]   Drosophila melanogaster
FBal0117635 Tak1[Scer\UAS.cTa]   Drosophila melanogaster
FBal0189550 Tak1[Scer\UAS.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0123982 Tak1[D159A.Scer\UAS]   Drosophila melanogaster
FBal0123981 Tak1[K46R.M.Scer\UAS]   Drosophila melanogaster
FBal0117636 Tak1[K46R.Scer\UAS]   Drosophila melanogaster
FBal0155766 Tak1[MtnA.T:Ivir\HA1]   Drosophila melanogaster
FBal0123980 Tak1[Scer\UAS.cMa]   Drosophila melanogaster
FBal0193044 Tak1[Delta.MtnA.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0194041 Tak1[179] loss of function allele Drosophila melanogaster
FBal0214808 Tak1[GD9587]   Drosophila melanogaster
FBal0235687 Tak1[KK108611]   Drosophila melanogaster

40 Clones

Secondary Identifier DB identifier
DPiM_LD42274 FBcl0741714
EK197320 FBcl0114398
EK152105 FBcl0114424
EK251253 FBcl0114460
EK239507 FBcl0114468
EK255422 FBcl0114474
EK156158 FBcl0114536
GM09711 FBcl0140019
GM05307 FBcl0140023
GM05309 FBcl0140025
LD03417 FBcl0153744
LD18615 FBcl0153750
LD19664 FBcl0153753
LD29291 FBcl0166823
LD38793 FBcl0166829
LD42274 FBcl0166830
RE17262 FBcl0203006
RE59570 FBcl0203225
RE35770 FBcl0203230
RE43994 FBcl0203237
RE23409 FBcl0203241
RE60865 FBcl0203246
SD02250 FBcl0280640
SD06739 FBcl0280662
EC056460 FBcl0299201
EC053525 FBcl0299203
EC051013 FBcl0299204
EC054011 FBcl0299207
Dmel_neb_012142_0400_1651 FBcl0367395
Dmel_neb_011820_0150_0435 FBcl0367391

9 Exons

DB identifier Symbol
FBgn0026323:9 Tak1:9
FBgn0026323:8 Tak1:8
FBgn0026323:7 Tak1:7
FBgn0026323:6 Tak1:6
FBgn0026323:5 Tak1:5
FBgn0026323:4 Tak1:4
FBgn0026323:2 Tak1:2
FBgn0026323:1 Tak1:1
FBgn0026323:3 Tak1:3

2 Transcripts

DB identifier Gene
FBtr0077319 Tak1
FBtr0340404 Tak1

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0077319-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0340404-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0077319-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0340404-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
39659 NCBI Entrez Gene identifiers FBgn0026323
64981 BioGRID FBgn0026323

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 636.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 657.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 551.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 512.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 582.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 658.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 997.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1041.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 459.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1043.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 795.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 541.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 666.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 506.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 577.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 467.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 752.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 651.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 768.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 470.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 704.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 678.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 451.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 864.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 387.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1378.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1015.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 992.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 796.0
FBgn0026323 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 924.0

8 Introns

DB identifier
Organism . Name
intron_FBgn0026323:9_FBgn0026323:8 Drosophila melanogaster
intron_FBgn0026323:8_FBgn0026323:7 Drosophila melanogaster
intron_FBgn0026323:7_FBgn0026323:6 Drosophila melanogaster
intron_FBgn0026323:6_FBgn0026323:5 Drosophila melanogaster
intron_FBgn0026323:5_FBgn0026323:4 Drosophila melanogaster
intron_FBgn0026323:4_FBgn0026323:2 Drosophila melanogaster
intron_FBgn0026323:2_FBgn0026323:1 Drosophila melanogaster
intron_FBgn0026323:3_FBgn0026323:2 Drosophila melanogaster

28 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Tak1 none -0.382923097   19067489
Lipid storage Tak1 none -1.185966518   19067489
Lipid storage Tak1 none 0.557522251   19067489
Lipid storage Tak1 none 0.13288923   19067489
Lipid storage Tak1 none 1.393394371   19067489
Lipid storage Tak1 none 0.127423691   19067489
ERK signaling Tak1 ERK activation reduced moderate   17086199
Cell cycle regulation (1) Tak1 none np   15616552
Cell cycle regulation (2) Tak1 none np   15616552
Innate immunity Tak1 Decreased IMD/Rel reporter activity -5.2   16170305
Cell size and cell-cycle regulation (1) Tak1 none sp   16496002
Cell size and cell-cycle regulation (1) Tak1 none sp   16496002
PGN-induced dJNK phosphorylation Tak1 Decreased P-JNK protein expression with PGN -5.7 15 min PGN induction 19893628
Akt-TOR pathway negative feedback regulation Tak1 Decreased dAkt phosphorylation after insulin stimulation -3.1 10 min insulin stimulation 20585550
Pol II elongation Tak1 none 91 20 min heat shock 19279664
Actin organization and cell morphology (1) Tak1 none np   19265526
Actin organization and cell morphology (2) Tak1 none np   19265526
Actin organization and cell morphology (3) Tak1 none np   19265526
Actin organization and cell morphology (4) Tak1 none np   19265526
Actin organization and cell morphology (5) Tak1 none np   19265526
Actin organization and cell morphology (6) Tak1 none np   19265526
Vaccinia virus infection Tak1 none sp   20585561
RTK-Ras-ERK pathway regulation (1) Tak1 none -0.29 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Tak1 none 0.02 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Tak1 none -0.56 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Tak1 none 0.02 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation Tak1 none -0.24   23263283
Glycosylation regulation (1) Tak1 none sp   21203496

0 Submissions