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Gene : Sec23 D. melanogaster

DB identifier  ? FBgn0262125 Secondary Identifier  ? CG1250
Name  ? Sec23 ortholog (S. cerevisiae) Source  FlyBase
  • synonyms:
  • Sec23p,
  • dSec23p,
  • FBgn0037357,
  • Sec23A,
  • FBan0001250,
  • FBgn0011441,
  • dSec23,
  • hau,
  • dendritic arbor reduction 2,
  • CG1250,
  • l(3)j13C8,
  • dar2,
  • SEC23,
  • Haunted,
  • FBgn0262125,
  • FBgn0001178,
  • COPII

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13 Alleles

DB identifier Symbol Allele Class Organism
FBal0178050 Sec23[DG10106]   Drosophila melanogaster
FBal0248121 Sec23[HMS00356]   Drosophila melanogaster
FBal0210547 Sec23[GD7746]   Drosophila melanogaster
FBal0271268 Sec23[NIG.1250R]   Drosophila melanogaster
FBal0158686 Sec23[EY06757]   Drosophila melanogaster
FBal0215581 Sec23[8-2-55]   Drosophila melanogaster
FBal0005381 Sec23[11]   Drosophila melanogaster
FBal0010891 Sec23[j13C8]   Drosophila melanogaster
FBal0258791 Sec23[KK100659]   Drosophila melanogaster
FBal0086551 Sec23[unspecified]   Drosophila melanogaster
FBal0244810 Sec23[CK] amorphic allele - genetic evidence Drosophila melanogaster
FBal0005382 Sec23[9G] amorphic allele - genetic evidence Drosophila melanogaster
FBal0005383 Sec23[1M]   Drosophila melanogaster

200 Clones

Secondary Identifier DB identifier
EK170619 FBcl0040790
EK112845 FBcl0040818
EK206809 FBcl0040844
EK056911 FBcl0042362
EK240715 FBcl0042532
EK245839 FBcl0042554
EK271505 FBcl0042790
EK302404 FBcl0042810
EK092925 FBcl0043408
EK048206 FBcl0043430
EK235456 FBcl0043452
EK261757 FBcl0043656
EK173855 FBcl0043676
EK186921 FBcl0043698
EK189642 FBcl0044652
EK196433 FBcl0044678
EK201114 FBcl0045676
EP00660 FBcl0075391
EP07605 FBcl0075445
EN03358 FBcl0091753
EN04742 FBcl0091769
EN01614 FBcl0091871
GH11766 FBcl0112245
GH10571 FBcl0112337
GH07344 FBcl0112391
GH24180 FBcl0112555
GH15625 FBcl0112595
GH22773 FBcl0112869
GH23373 FBcl0112949
GH01163 FBcl0112981

11 Exons

DB identifier Symbol
FBgn0262125:2 sec23:2
FBgn0262125:5 sec23:5
FBgn0262125:6 sec23:6
FBgn0262125:7 sec23:7
FBgn0262125:8 sec23:8
FBgn0262125:10 sec23:10
FBgn0262125:11 sec23:11
FBgn0262125:3 sec23:3
FBgn0262125:9 sec23:9
FBgn0262125:4 sec23:4
FBgn0262125:1 sec23:1

7 Transcripts

DB identifier Gene
FBtr0309091 Sec23
FBtr0330314 Sec23
FBtr0339320 Sec23
FBtr0078711 Sec23
FBtr0310266 Sec23
FBtr0078710 Sec23
FBtr0304794 Sec23

14 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0309091-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0304794-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0310266-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0078710-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0078711-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0330314-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0339320-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0309091-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0304794-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0310266-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0078710-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0078711-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0330314-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0339320-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
40694 NCBI Entrez Gene identifiers FBgn0262125
65900 BioGRID FBgn0262125

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

13 Introns

DB identifier
Organism . Name
intron_FBgn0262125:2_FBgn0262125:5 Drosophila melanogaster
intron_FBgn0262125:5_FBgn0262125:6 Drosophila melanogaster
intron_FBgn0262125:6_FBgn0262125:7 Drosophila melanogaster
intron_FBgn0262125:7_FBgn0262125:8 Drosophila melanogaster
intron_FBgn0262125:8_FBgn0262125:10 Drosophila melanogaster
intron_FBgn0262125:10_FBgn0262125:11 Drosophila melanogaster
intron_FBgn0262125:1_FBgn0262125:5 Drosophila melanogaster
intron_FBgn0262125:8_FBgn0262125:11 Drosophila melanogaster
intron_FBgn0262125:2_FBgn0262125:4 Drosophila melanogaster
intron_FBgn0262125:4_FBgn0262125:6 Drosophila melanogaster
intron_FBgn0262125:8_FBgn0262125:9 Drosophila melanogaster
intron_FBgn0262125:9_FBgn0262125:11 Drosophila melanogaster
intron_FBgn0262125:3_FBgn0262125:6 Drosophila melanogaster

28 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Sec23 none -0.542909013   19067489
Lipid storage Sec23 none -0.507502784   19067489
Lipid storage Sec23 none -3.216569473   19067489
Lipid storage Sec23 none 4.190925787   19067489
Intracellular Listeria monocytogenes infection Sec23 Decreased GFP protein expression moderate   16020693
Mycobacterial infection (1) - M. fortuitum infection Sec23 Decreased M. fortuitum intracellular infection 4.7 measurement after 3 days 16020694
Mycobacterial infection (2) - E. coli phagocytosis Sec23 Decreased E. coli phagocytosis np   16020694
Constitutive protein secretion and Golgi organization (1) Sec23 Decreased horseradish peroxidase protein expression sp   16452979
Constitutive protein secretion and Golgi organization (2) Sec23 Fused Golgi membranes with endoplasmic reticulum np   16452979
Cell size and cell-cycle regulation (1) Sec23 none sp   16496002
Brucella melitensis infection Sec23 Decreased Brucella melitensis infection 1.75   18654626
Combinatorial effect with methyl methanesulphonate (1) Sec23 Synthetic lethal with methyl methanesulphonate sp   19543366
Combinatorial effect with methyl methanesulphonate (2) Sec23 Synthetic lethal with methyl methanesulphonate sp   19543366
Mutant human huntingtin aggregation Sec23 Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) Sec23 Lethal np   20220848
Heat nociception (1) Sec23 Developmentally lethal 0   21074052
Notch pathway regulation (4) Sec23 Completely lethal (before pupal) sp   19363474
PGN-induced dJNK phosphorylation Sec23 Increased P-JNK protein expression with PGN 3.19 15 min PGN induction 19893628
Akt-TOR pathway negative feedback regulation Sec23 Decreased dAkt phosphorylation after insulin stimulation -2.8 10 min insulin stimulation 20585550
Secretory pathway regulation Sec23 Decreased BiP signal peptide and firefly luciferase fusion protein expression < -2   19942856
RTK-Ras-ERK pathway regulation (1) Sec23 Increased ERK phosphorylation after EGF stimulation 1.53 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Sec23 none 0.05 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Sec23 none -0.15 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Sec23 none 0.48 10 minutes sSpitz stimulation 22028469
Wnt proteins secretion Sec23 none -0.8   22094269
Hippo pathway regulation Sec23 none -0.56   23263283
Glycosylation regulation (1) Sec23 Lethal np   21203496
Huntingtin (Htt) aggregates formation Sec23 Decreased formation of mutant Huntingtin (Httex1-Qn) protein aggregates np   20100940

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