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Gene : Hsc70-4 D. melanogaster

DB identifier  ? FBgn0001219 Secondary Identifier  ? CG4264
Name  ? Heat shock protein cognate 4 Source  FlyBase
  • synonyms:
  • CG4264,
  • Hsc4p,
  • Q3KN45_DROME,
  • dhsc70,
  • Heat shock protein 70,
  • Heat shock 70-kDa protein cognate 4,
  • bs17d06.y1,
  • l(3)L3929,
  • heat shock cognate protein 4,
  • anon-WO0118547.237,
  • scd,
  • E(nd)195,
  • Hsp cognate 4,
  • FBgn0024549,
  • scattered,
  • HSC70,
  • Hsp70,
  • Heat shock cognate 4,
  • FBgn0011400,
  • i190,
  • HSC4,
  • HSC-70,
  • FBgn0062154,
  • heat shock cognate protein 70-4,
  • l(3)j7A4,
  • Hsc-4,
  • heat-shock protein 70,
  • Hsp-c4,
  • FBan0004264,
  • FBgn0010802,
  • E(csp)1545,
  • BAP74,
  • HSC70-4,
  • l(3)03550,
  • FBgn0001219

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52 Alleles

DB identifier Symbol Allele Class Organism
FBal0211929 Hsc70-4[CB05603]   Drosophila melanogaster
FBal0160306 Hsc70-4[PBss]   Drosophila melanogaster
FBal0156375 Hsc70-4[Wee-P1]   Drosophila melanogaster
FBal0183183 Hsc70-4[d09679]   Drosophila melanogaster
FBal0183184 Hsc70-4[d02363]   Drosophila melanogaster
FBal0183181 Hsc70-4[f07231]   Drosophila melanogaster
FBal0183182 Hsc70-4[f01123]   Drosophila melanogaster
FBal0009472 Hsc70-4[03550] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0010988 Hsc70-4[j7A4]   Drosophila melanogaster
FBal0087006 Hsc70-4[L3929]   Drosophila melanogaster
FBal0124172 Hsc70-4[EP859]   Drosophila melanogaster
FBal0101645 Hsc70-4[j1C1]   Drosophila melanogaster
FBal0101646 Hsc70-4[L4083b]   Drosophila melanogaster
FBal0105150 Hsc70-4[195] loss of function allele, gain of function allele Drosophila melanogaster
FBal0124177 Hsc70-4[Delta19] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0124174 Hsc70-4[Delta356] loss of function allele Drosophila melanogaster
FBal0105151 Hsc70-4[+t14]   Drosophila melanogaster
FBal0144801 Hsc70-4[HS1-25]   Drosophila melanogaster
FBal0124170 Hsc70-4[II-R35-R2]   Drosophila melanogaster
FBal0105148 Hsc70-4[PA2]   Drosophila melanogaster
FBal0105147 Hsc70-4[PB2]   Drosophila melanogaster
FBal0124175 Hsc70-4[Delta27]   Drosophila melanogaster
FBal0124168 Hsc70-4[R12]   Drosophila melanogaster
FBal0124171 Hsc70-4[I-R35-R7]   Drosophila melanogaster
FBal0105149 Hsc70-4[EJ3]   Drosophila melanogaster
FBal0124176 Hsc70-4[Delta21]   Drosophila melanogaster
FBal0105145 Hsc70-4[XK1]   Drosophila melanogaster
FBal0124179 Hsc70-4[Delta11] loss of function allele Drosophila melanogaster
FBal0135975 Hsc70-4[dsRNA.cRa]   Drosophila melanogaster
FBal0105146 Hsc70-4[PG4]   Drosophila melanogaster

1474 Clones

Secondary Identifier DB identifier
ESG019d.E21_G06 FBcl0000114
AT16567 FBcl0034265
UUGC0921 FBcl0005103
AT31033 FBcl0034419
AT17452 FBcl0034429
AT27754 FBcl0034445
AT25561 FBcl0034451
AT26327 FBcl0034463
AT23512 FBcl0034567
AT27849 FBcl0034575
AT25955 FBcl0034579
AT15776 FBcl0034619
AT03278 FBcl0034623
AT17488 FBcl0034633
AT26855 FBcl0034635
AT18134 FBcl0034643
AT22051 FBcl0034645
AT06171 FBcl0034647
AT03815 FBcl0034659
AT01872 FBcl0034681
AT19466 FBcl0034685
AT17439 FBcl0034689
AT15624 FBcl0034787
EK084840 FBcl0057674
EK290536 FBcl0057688
EK069548 FBcl0057694
EK197060 FBcl0057700
EK228706 FBcl0057704
EK190826 FBcl0057710
EK225543 FBcl0060542

8 Exons

DB identifier Symbol
FBgn0001219:4 Hsc70-4:4
FBgn0001219:8 Hsc70-4:8
FBgn0001219:7 Hsc70-4:7
FBgn0001219:1 Hsc70-4:1
FBgn0001219:3 Hsc70-4:3
FBgn0001219:5 Hsc70-4:5
FBgn0001219:6 Hsc70-4:6
FBgn0001219:2 Hsc70-4:2

7 Transcripts

DB identifier Gene
FBtr0083060 Hsc70-4
FBtr0083055 Hsc70-4
FBtr0083056 Hsc70-4
FBtr0083058 Hsc70-4
FBtr0083059 Hsc70-4
FBtr0083057 Hsc70-4
FBtr0337053 Hsc70-4

14 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0083055-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083056-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083057-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083058-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083059-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083060-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0337053-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083055-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083056-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083057-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083058-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083059-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083060-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0337053-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
41840 NCBI Entrez Gene identifiers FBgn0001219
66904 BioGRID FBgn0001219

5 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
GenomeRNAi data set  
TreeFam data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 12963.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 13831.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 14197.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 17667.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 15125.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 14377.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 12499.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 15738.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 10238.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 13090.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 10987.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 13303.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 14813.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 19101.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 15938.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 15479.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 13020.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 12316.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 15345.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 10389.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 14509.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 10394.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 8958.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 7192.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 7287.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 12770.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 12875.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 11278.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 9439.0
FBgn0001219 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 10892.0

6 Introns

DB identifier
Organism . Name
intron_FBgn0001219:6_FBgn0001219:8 Drosophila melanogaster
intron_FBgn0001219:4_FBgn0001219:8 Drosophila melanogaster
intron_FBgn0001219:3_FBgn0001219:8 Drosophila melanogaster
intron_FBgn0001219:5_FBgn0001219:8 Drosophila melanogaster
intron_FBgn0001219:1_FBgn0001219:8 Drosophila melanogaster
intron_FBgn0001219:2_FBgn0001219:8 Drosophila melanogaster

35 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Hsc70-4 none 1.203112686   19067489
Lipid storage Hsc70-4 none 6.263285336   19067489
Chlamydia caviae infection Hsc70-4 Decreased Chlamydia caviae infection np   17967059
E. coli / S. aureus infection Hsc70-4 Decreased phagocytosis np   11912489
Cytokinesis regulation Hsc70-4 Binucleate cells weak   15547975
Constitutive protein secretion and Golgi organization (1) Hsc70-4 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Hsc70-4 none sp   16496002
Cell size and cell-cycle regulation (1) Hsc70-4 none sp   16496002
RNAi pathway Hsc70-4 Decreased RNAi effect 9   16882716
Influenza replication Hsc70-4 Decreased Influenza replication -2.71/-2.51   18615016
Microtubule assembly and organization Hsc70-4 none np   18463163
Muscle morphogenesis and function (1) Hsc70-4 Flightless np   20220848
Muscle morphogenesis and function (2) Hsc70-4 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (4) Hsc70-4 Frayed myofibrils, fuzzy (broadened) Z-line np   20220848
Heart development and function (1) Hsc70-4 none 1   20371351
Heart development and function (1) Hsc70-4 none 1   20371351
Heart development and function (2) Hsc70-4 Decreased viability 4.11   20371351
Heart development and function (2) Hsc70-4 Decreased viability 6.13   20371351
Serratia marcescens infection (1) Hsc70-4 none -0.911111111111111   19520911
Notch pathway regulation (4) Hsc70-4 Notum malformation death 8   19363474
PGN-induced dJNK phosphorylation Hsc70-4 Increased P-JNK protein expression with PGN 2.18 15 min PGN induction 19893628
Akt-TOR pathway negative feedback regulation Hsc70-4 Decreased dAkt phosphorylation after insulin stimulation -3.2 10 min insulin stimulation 20585550
Adiposity regulation (1) Hsc70-4 Decreased triglyceride expression -0.662   20074523
Adiposity regulation (2) Hsc70-4 Lethal or developmental delay d/l   20074523
Adiposity regulation (3) Hsc70-4 Increased triglyceride expression 0.766   20074523
Adiposity regulation (4) Hsc70-4 Lethal or developmental delay d/l   20074523
Adiposity regulation (5) Hsc70-4 Decreased triglyceride expression -0.59   20074523
RTK-Ras-ERK pathway regulation (1) Hsc70-4 Decreased ERK phosphorylation after EGF stimulation -4.78 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Hsc70-4 Decreased ERK phosphorylation after EGF stimulation -1.76 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Hsc70-4 none 0.52 30 minutes sSpitz stimulation 22028469

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