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Gene : RasGAP1 D. melanogaster

DB identifier  ? FBgn0004390 Secondary Identifier  ? CG6721
Name  ? Ras GTPase activating protein 1 Source  FlyBase
  • synonyms:
  • sxt,
  • GTPase-activating protein 1,
  • GAP1,
  • FBgn0004390,
  • CG6721,
  • GTPase activating protein 1,
  • GTPase activating protein1,
  • Ras-GAP,
  • rasGAP,
  • seven extra,
  • rI533,
  • FBan0006721,
  • mip,
  • GAP,
  • FBgn0005621,
  • sextra,
  • more inner photoreceptors,
  • Gap 1

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65 Alleles

DB identifier Symbol Allele Class Organism
FBal0283173 RasGAP1[c255]   Drosophila melanogaster
FBal0183456 RasGAP1[d08202]   Drosophila melanogaster
FBal0033722 RasGAP1[B5]   Drosophila melanogaster
FBal0094023 RasGAP1[21-1s]   Drosophila melanogaster
FBal0029793 RasGAP1[1]   Drosophila melanogaster
FBal0029796 RasGAP1[mip-w+] loss of function allele Drosophila melanogaster
FBal0193407 RasGAP1[E21F.2]   Drosophila melanogaster
FBal0095715 RasGAP1[DeltaPH-Q.sev]   Drosophila melanogaster
FBal0260895 RasGAP1[rI533] loss of function allele Drosophila melanogaster
FBal0029795 RasGAP1[B2] amorphic allele - genetic evidence Drosophila melanogaster
FBal0095714 RasGAP1[DeltaQ.sev]   Drosophila melanogaster
FBal0095710 RasGAP1[R786C.sev]   Drosophila melanogaster
FBal0066063 RasGAP1[HSA.6]   Drosophila melanogaster
FBal0183457 RasGAP1[c06619]   Drosophila melanogaster
FBal0230701 RasGAP1[KK100364]   Drosophila melanogaster
FBal0029794 RasGAP1[B1] amorphic allele - genetic evidence Drosophila melanogaster
FBal0123168 RasGAP1[Scim-b]   Drosophila melanogaster
FBal0156441 RasGAP1[dsRNA.si.cKa]   Drosophila melanogaster
FBal0190324 RasGAP1[Scer\UAS.cUa]   Drosophila melanogaster
FBal0058736 RasGAP1[deltaC6]   Drosophila melanogaster
FBal0086833 RasGAP1[A13P]   Drosophila melanogaster
FBal0240206 RasGAP1[r2533]   Drosophila melanogaster
FBal0044837 RasGAP1[H142]   Drosophila melanogaster
FBal0095717 RasGAP1[DeltaC2b.sev]   Drosophila melanogaster
FBal0207090 RasGAP1[GD12823]   Drosophila melanogaster
FBal0033721 RasGAP1[B4]   Drosophila melanogaster
FBal0066064 RasGAP1[HSA.5]   Drosophila melanogaster
FBal0038841 RasGAP1[deltaB4]   Drosophila melanogaster
FBal0123169 RasGAP1[Scim-a]   Drosophila melanogaster
FBal0066067 RasGAP1[HSA.2]   Drosophila melanogaster

100 Clones

Secondary Identifier DB identifier
DPiM_LD27520 FBcl0741481
UUGC1012 FBcl0005435
UUGC1095 FBcl0005807
EK194721 FBcl0076260
EK302507 FBcl0076302
EK057460 FBcl0076430
EK248657 FBcl0076442
EK070040 FBcl0076542
EK017818 FBcl0076576
EK260028 FBcl0076590
EK174016 FBcl0076636
EK155332 FBcl0076658
EK048112 FBcl0076698
EK018841 FBcl0076712
EK088046 FBcl0076720
EK181360 FBcl0076734
EK157011 FBcl0076758
EK231717 FBcl0076768
EK207218 FBcl0076780
EK020236 FBcl0076802
EK161732 FBcl0076820
EK136406 FBcl0076844
EK084311 FBcl0076886
EP15020 FBcl0078529
EP18920 FBcl0078539
EP10853 FBcl0078541
LD08362 FBcl0155832
LD03770 FBcl0155833
LD05775 FBcl0155834
LD13694 FBcl0155835

6 Exons

DB identifier Symbol
FBgn0004390:6 Gap1:6
FBgn0004390:5 Gap1:5
FBgn0004390:4 Gap1:4
FBgn0004390:3 Gap1:3
FBgn0004390:2 Gap1:2
FBgn0004390:1 Gap1:1

3 Transcripts

DB identifier Gene
FBtr0076368 RasGAP1
FBtr0330168 RasGAP1
FBtr0076367 RasGAP1

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0076367-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0076368-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0330168-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076367-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076368-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0330168-3-prime-utr Drosophila melanogaster

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0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
39158 NCBI Entrez Gene identifiers FBgn0004390
64545 BioGRID FBgn0004390

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1395.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1088.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 827.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 651.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 574.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 699.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 638.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 882.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 852.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1223.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 217.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 712.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 668.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 843.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 3574.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1468.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1913.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1058.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1238.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1831.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 9967.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 675.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1387.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 810.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 719.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1800.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1686.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1500.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1251.0
FBgn0004390 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1354.0

5 Introns

DB identifier
Organism . Name
intron_FBgn0004390:6_FBgn0004390:5 Drosophila melanogaster
intron_FBgn0004390:5_FBgn0004390:4 Drosophila melanogaster
intron_FBgn0004390:4_FBgn0004390:3 Drosophila melanogaster
intron_FBgn0004390:3_FBgn0004390:1 Drosophila melanogaster
intron_FBgn0004390:3_FBgn0004390:2 Drosophila melanogaster

34 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation RasGAP1 none 0.01   19216764
Lipid storage RasGAP1 none 0.359729804   19067489
Lipid storage RasGAP1 none -0.455514181   19067489
Neural outgrowth RasGAP1 Defasciculation np   18604272
ERK signaling RasGAP1 ERK activation increased strong   17086199
Innate immunity RasGAP1 Decreased IMD/Rel reporter activity -3.5   16170305
Cell size and cell-cycle regulation (1) RasGAP1 Increased G1 cell size sp   16496002
Cell size and cell-cycle regulation (1) RasGAP1 none sp   16496002
Cell size and cell-cycle regulation (1) RasGAP1 none sp   16496002
Cell size and cell-cycle regulation (2) RasGAP1 none 1.357   16496002
Cell size and cell-cycle regulation (3) RasGAP1 none 452   16496002
Heart development and function RasGAP1 Heart maturation defects, thinner heart tube np   14684833
Muscle morphogenesis and function (1) RasGAP1 Lethal np   20220848
Muscle morphogenesis and function (2) RasGAP1 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) RasGAP1 Spotty (discontinuous) Z-line np   20220848
Heat nociception (1) RasGAP1 Developmentally lethal -0.82   21074052
Heat nociception (1) RasGAP1 Increased noxious heat avoidance 1.72   21074052
Heat nociception (2) RasGAP1 none 30.66666667   21074052
Heart development and function (1) RasGAP1 none 1   20371351
Serratia marcescens infection (1) RasGAP1 none -0.0652173913043478   19520911
Serratia marcescens infection (1) RasGAP1 none 0.4375   19520911
Notch pathway regulation (4) RasGAP1 Notum malformation death 10   19363474
Notch pathway regulation (4) RasGAP1 Completely lethal (pupal) sp   19363474
Self-renewal and differentiation in neural stem cells RasGAP1 Neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underproliferation, lethal sp   21549331
Adiposity regulation (1) RasGAP1 Increased triglyceride expression 0.473   20074523
Adiposity regulation (2) RasGAP1 Increased triglyceride expression 0.35   20074523
Adiposity regulation (3) RasGAP1 Lethal or developmental delay d/l   20074523
Adiposity regulation (4) RasGAP1 none 0.238   20074523
Adiposity regulation (5) RasGAP1 Decreased triglyceride expression -1   20074523
RTK-Ras-ERK pathway regulation (1) RasGAP1 Increased ERK phosphorylation after EGF stimulation 4.51 0 minutes EGF stimulation 22028469

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