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Gene : Prosbeta6 D. melanogaster

DB identifier  ? FBgn0002284 Secondary Identifier  ? CG4097
Name  ? Proteasome beta6 subunit Source  FlyBase
  • synonyms:
  • 20S proteasome,
  • l(3)DTS-5,
  • b6,
  • Pros26-DTS,
  • Proteasome 26kD subunit,
  • DTS-5,
  • PSMB1,
  • l(3)DTS5,
  • Pros26,
  • FBgn0010150,
  • CG4097,
  • Prosbeta6,
  • PSB1_DROME,
  • beta6,
  • l(3)73Ai,
  • beta6_dm,
  • beta6 proteosome subunit,
  • FBan0004097,
  • Beta-6,
  • Proteasome subunit 20S,
  • FBgn0002284,
  • DTS5

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18 Alleles

DB identifier Symbol Allele Class Organism
FBal0238962 Prosbeta6[G9075]   Drosophila melanogaster
FBal0010023 Prosbeta6[3] loss of function allele Drosophila melanogaster
FBal0010022 Prosbeta6[2] loss of function allele Drosophila melanogaster
FBal0101587 Prosbeta6[1.Scer\UAS]   Drosophila melanogaster
FBal0010021 Prosbeta6[1]   Drosophila melanogaster
FBal0208134 Prosbeta6[GD11216]   Drosophila melanogaster
FBal0119427 Prosbeta6[unspecified]   Drosophila melanogaster
FBal0231593 Prosbeta6[KK102006]   Drosophila melanogaster
FBal0033966 Prosbeta6[Act5C.P]   Drosophila melanogaster
FBal0034879 Prosbeta6[+t3.5]   Drosophila melanogaster
FBal0034880 Prosbeta6[7.9B]   Drosophila melanogaster
FBal0095632 Prosbeta6[rv10e] loss of function allele Drosophila melanogaster
FBal0042711 Prosbeta6[1.tSa] heat sensitive gain of function allele Drosophila melanogaster
FBal0263115 Prosbeta6[HMS00110]   Drosophila melanogaster
FBal0141582 Prosbeta6[1.B.Scer\UAS]   Drosophila melanogaster
FBal0286900 Prosbeta6[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286901 Prosbeta6[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0274088 Prosbeta6[NIG.4097R]   Drosophila melanogaster

71 Clones

Secondary Identifier DB identifier
ESG0117c.B21_B04 FBcl0003301
AT29806 FBcl0009663
AT30959 FBcl0009723
EK043313 FBcl0041490
EK113531 FBcl0042622
bs59e12 FBcl0048435
EC01461 FBcl0062881
EC26974 FBcl0062885
EC43774 FBcl0062887
EN01421 FBcl0092447
EK056508 FBcl0101856
EK212949 FBcl0101874
EK173457 FBcl0101908
EK165729 FBcl0101954
GM10441 FBcl0138667
GM09866 FBcl0138677
GM03075 FBcl0138679
GM16563 FBcl0144588
LD05293 FBcl0152153
LD12621 FBcl0152155
LD03283 FBcl0152184
LD25747 FBcl0164701
LD24159 FBcl0164704
LD46028 FBcl0164722
LD46851 FBcl0164724
LD26249 FBcl0164726
LD37676 FBcl0164733
LD45690 FBcl0164736
LP03325 FBcl0180567
LP02194 FBcl0180572

2 Exons

DB identifier Symbol
FBgn0002284:2 Pros26:2
FBgn0002284:1 Pros26:1

1 Transcripts

DB identifier Gene
FBtr0075360 Prosbeta6

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0075360-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0075360-3-prime-utr Drosophila melanogaster

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74 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
39855 NCBI Entrez Gene identifiers FBgn0002284
65155 BioGRID FBgn0002284

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 2556.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 3030.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 2285.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 2376.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1938.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 2163.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 2010.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1608.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1625.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2416.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 2029.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1770.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1222.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1450.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1816.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1598.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1942.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1612.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1866.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 2252.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1380.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 2157.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 2030.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1717.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2052.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 4232.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 3659.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 2023.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1179.0
FBgn0002284 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1233.0

1 Introns

DB identifier
Organism . Name
intron_FBgn0002284:2_FBgn0002284:1 Drosophila melanogaster

35 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Prosbeta6 none -0.932468626   19067489
Lipid storage Prosbeta6 none 0.046409918   19067489
Lipid storage Prosbeta6 none -1.173683887   19067489
ERK signaling Prosbeta6 ERK activation reduced weak   17086199
Intracellular Listeria monocytogenes infection Prosbeta6 Decreased GFP protein expression strong   16020693
Hedgehog signaling Prosbeta6 Decreased Hedgehog reporter activity -2.71   16311596
Constitutive protein secretion and Golgi organization (1) Prosbeta6 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Prosbeta6 Decreased G1 DNA content sp   16496002
Cell size and cell-cycle regulation (2) Prosbeta6 none 1.239   16496002
Cell size and cell-cycle regulation (3) Prosbeta6 none 428   16496002
Cell size and cell-cycle regulation (4) Prosbeta6 none below threshold   16496002
Influenza replication Prosbeta6 Decreased Influenza replication -0.21/-2.96   18615016
Combinatorial effect with methyl methanesulphonate (2) Prosbeta6 none sp   19543366
Mutant human huntingtin aggregation Prosbeta6 Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) Prosbeta6 Lethal np   20220848
Muscle morphogenesis and function (2) Prosbeta6 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Heart development and function (1) Prosbeta6 Pupal lethal 0.31   20371351
Serratia marcescens infection (1) Prosbeta6 Decreased viability after Serratia marcescens infection -5.5576923076923   19520911
Serratia marcescens infection (1) Prosbeta6 Decreased viability after Serratia marcescens infection -2.47619047619047   19520911
Serratia marcescens infection (2) Prosbeta6 none sp   19520911
Serratia marcescens infection (6) Prosbeta6 Larval lethality or failure to eclose np   19520911
Notch pathway regulation (4) Prosbeta6 Completely lethal (pupal) sp   19363474
PGN-induced dJNK phosphorylation Prosbeta6 Increased P-JNK protein expression with PGN 2.06 15 min PGN induction 19893628
Muscle assembly and maintenance Prosbeta6 Muscles spread, myosin filaments striated, actin filaments lack striation severe   18359903
Hh pathway regulation Prosbeta6 Downregulation of Hh pathway -0.352110869729587   17903264
Hh pathway regulation Prosbeta6 none -0.242443107245613   17903264
Adiposity regulation (1) Prosbeta6 none -0.685   20074523
Blood cell homeostasis regulation (1) Prosbeta6 none np   20540764
Blood cell homeostasis regulation (2) Prosbeta6 none np   20540764
RTK-Ras-ERK pathway regulation (1) Prosbeta6 none -0.23 0 minutes EGF stimulation 22028469

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