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Gene : AP-2alpha D. melanogaster

DB identifier  ? FBgn0264855 Secondary Identifier  ? CG4260
Name  ? Adaptor Protein complex 2, alpha subunit Source  FlyBase
  • synonyms:
  • lethal (2) SH0460,
  • alpha,
  • AP-2,
  • CG31654,
  • alpha adaptin,
  • MENE(2L)-A,
  • apl3,
  • FBan0004260,
  • alpha-Ada,
  • l(2)06694,
  • Alpha-Adaptin,
  • l(2)SH0460,
  • ada,
  • dAP-2a,
  • D-Ada,
  • alphaAdaptin,
  • CG4260,
  • D-alphaAda,
  • FBgn0260562,
  • MENE (2L)-A,
  • FBgn0263350,
  • AP-2alpha,
  • FBgn0264855,
  • l(2)SH2 0460,
  • FBgn0010623,
  • AP2,
  • FBgn0065772,
  • FBgn0015567

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26 Alleles

DB identifier Symbol Allele Class Organism
FBal0270129 AP-2alpha[Trunk.Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0060816 AP-2alpha[3] amorphic allele - genetic evidence Drosophila melanogaster
FBal0270131 AP-2alpha[DeltaNTDeltaEar.Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0089856 AP-2alpha[EP2519]   Drosophila melanogaster
FBal0148526 AP-2alpha[ear26] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0270130 AP-2alpha[N2.Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0060817 AP-2alpha[2]   Drosophila melanogaster
FBal0257337 AP-2alpha[HMS00653]   Drosophila melanogaster
FBal0008113 AP-2alpha[06694] hypomorphic allele - molecular evidence, hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0261135 AP-2alpha[T1] loss of function allele Drosophila melanogaster
FBal0144009 AP-2alpha[SH0460] hypomorphic allele - molecular evidence Drosophila melanogaster
FBal0270126 AP-2alpha[Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0261134 AP-2alpha[Y9] loss of function allele Drosophila melanogaster
FBal0270128 AP-2alpha[DeltaEar.Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0270127 AP-2alpha[DeltaEar5.Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0148525 AP-2alpha[ear4]   Drosophila melanogaster
FBal0101841 AP-2alpha[4] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0148524 AP-2alpha[ear5]   Drosophila melanogaster
FBal0219035 AP-2alpha[40-31] loss of function allele Drosophila melanogaster
FBal0278495 AP-2alpha[MI06502]   Drosophila melanogaster
FBal0261136 AP-2alpha[W5] loss of function allele Drosophila melanogaster
FBal0241094 AP-2alpha[dsRNA.Scer\UAS.cUa]   Drosophila melanogaster
FBal0123350 AP-2alpha[EP896]   Drosophila melanogaster
FBal0198529 AP-2alpha[GD5059]   Drosophila melanogaster
FBal0273513 AP-2alpha[NIG.31654R]   Drosophila melanogaster
FBal0274160 AP-2alpha[NIG.4260R]   Drosophila melanogaster

71 Clones

Secondary Identifier DB identifier
CK01074 FBcl0058911
EK268326 FBcl0067366
EK220218 FBcl0067672
EK266362 FBcl0067822
EK230631 FBcl0067860
EK052119 FBcl0067906
EK064515 FBcl0067948
EK271835 FBcl0067968
EK277649 FBcl0067988
EK154136 FBcl0068006
EK152024 FBcl0068026
EK100115 FBcl0068046
EK209863 FBcl0068066
EK255260 FBcl0068086
EK096462 FBcl0068106
EK079825 FBcl0068122
EK089948 FBcl0068160
EK087425 FBcl0068180
EK047827 FBcl0068200
EK041104 FBcl0070198
EK261706 FBcl0070218
EK100120 FBcl0070566
EK104439 FBcl0071820
EK175135 FBcl0071858
EK131411 FBcl0071878
EP13862 FBcl0074181
GH12572 FBcl0116753
GH08828 FBcl0116759
GH09237 FBcl0116833
LD01019 FBcl0156021

11 Exons

DB identifier Symbol
FBgn0263350:9 alpha-Adaptin:9
FBgn0263350:8 alpha-Adaptin:8
FBgn0263350:7 alpha-Adaptin:7
FBgn0263350:6 alpha-Adaptin:6
FBgn0263350:5 alpha-Adaptin:5
FBgn0263350:4 alpha-Adaptin:4
FBgn0263350:3 alpha-Adaptin:3
FBgn0263350:2 alpha-Adaptin:2
FBgn0263350:11 alpha-Adaptin:11
FBgn0263350:10 alpha-Adaptin:10
FBgn0263350:1 alpha-Adaptin:1

2 Transcripts

DB identifier Gene
FBtr0089488 AP-2alpha
FBtr0089489 AP-2alpha

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0089488-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0089489-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0089488-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0089489-3-prime-utr Drosophila melanogaster

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3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
33211 NCBI Entrez Gene identifiers FBgn0264855
42738 NCBI Entrez Gene identifiers FBgn0264855
59467 BioGRID FBgn0264855

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

10 Introns

DB identifier
Organism . Name
intron_FBgn0263350:11_FBgn0263350:10 Drosophila melanogaster
intron_FBgn0263350:10_FBgn0263350:8 Drosophila melanogaster
intron_FBgn0263350:8_FBgn0263350:7 Drosophila melanogaster
intron_FBgn0263350:7_FBgn0263350:6 Drosophila melanogaster
intron_FBgn0263350:6_FBgn0263350:5 Drosophila melanogaster
intron_FBgn0263350:5_FBgn0263350:4 Drosophila melanogaster
intron_FBgn0263350:4_FBgn0263350:3 Drosophila melanogaster
intron_FBgn0263350:3_FBgn0263350:1 Drosophila melanogaster
intron_FBgn0263350:9_FBgn0263350:8 Drosophila melanogaster
intron_FBgn0263350:3_FBgn0263350:2 Drosophila melanogaster

25 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage AP-2alpha none 0.661309047   19067489
Lipid storage AP-2alpha none 1.181095001   19067489
Insect dengue virus infection AP-2alpha Inhibition of dengue virus propagation 2.3 (0.018)   19396146
ERK signaling AP-2alpha ERK activation increased weak   17086199
Cell size and cell-cycle regulation (1) AP-2alpha none sp   16496002
Cell size and cell-cycle regulation (1) AP-2alpha none sp   16496002
CD4 regulation by human immunodeficiency virus Type 1 Nef (HIV-1 Nef) AP-2alpha none 2.75   17267500
Microtubule assembly and organization AP-2alpha none np   18463163
Muscle morphogenesis and function (1) AP-2alpha Lethal np   20220848
Muscle morphogenesis and function (1) AP-2alpha Locomotion defect np   20220848
Heat nociception (1) AP-2alpha Increased noxious heat avoidance 1.81   21074052
Heat nociception (2) AP-2alpha none 27.33333333   21074052
Heart development and function (1) AP-2alpha none 1   20371351
Serratia marcescens infection (1) AP-2alpha none 1.15492957746478   19520911
Notch pathway regulation (4) AP-2alpha Completely lethal (pupal) sp   19363474
Notch pathway regulation (4) AP-2alpha Completely lethal (pupal) sp   19363474
Self-renewal and differentiation in neural stem cells AP-2alpha Neuroblast more large cells, neuroblast overproliferation, lethal sp   21549331
Self-renewal and differentiation in neural stem cells AP-2alpha GFP aggregates number, GFP aggregates size, neuroblast more large cells, neuroblast overproliferation, lethal sp   21549331
RTK-Ras-ERK pathway regulation (1) AP-2alpha none 0.29 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) AP-2alpha Increased ERK phosphorylation after EGF stimulation 1.75 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) AP-2alpha none 0.63 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) AP-2alpha none 0.95 10 minutes sSpitz stimulation 22028469
Wnt proteins secretion AP-2alpha none -1.1   22094269
Hippo pathway regulation AP-2alpha none -0.66   23263283
Glycosylation regulation (1) AP-2alpha none sp   21203496

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