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Gene : Rpn3 D. melanogaster

DB identifier  ? FBgn0261396 Secondary Identifier  ? CG42641
Name  ? Regulatory particle non-ATPase 3 Source  FlyBase
  • synonyms:
  • DoxA2,
  • DXA2_DROME,
  • FBgn0261364,
  • RPN3,
  • Diphenol oxidase-A2,
  • CG42641,
  • FBan0010484,
  • l(2)37Bf[+],
  • S3,
  • p58,
  • l(2)37Bf,
  • Dox,
  • Dox-A2,
  • FBgn0000486,
  • FBgn0261396,
  • CG10484,
  • Diphenol oxidase A2

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14 Alleles

DB identifier Symbol Allele Class Organism
FBal0241737 Rpn3[HM05247]   Drosophila melanogaster
FBal0257699 Rpn3[HMS01033]   Drosophila melanogaster
FBal0270486 Rpn3[NIG.10484R]   Drosophila melanogaster
FBal0044750 Rpn3[+t5.2]   Drosophila melanogaster
FBal0002762 Rpn3[mfs1]   Drosophila melanogaster
FBal0206888 Rpn3[GD6990]   Drosophila melanogaster
FBal0002760 Rpn3[2]   Drosophila melanogaster
FBal0044751 Rpn3[B4]   Drosophila melanogaster
FBal0002759 Rpn3[1]   Drosophila melanogaster
FBal0002761 Rpn3[3]   Drosophila melanogaster
FBal0002763 Rpn3[5]   Drosophila melanogaster
FBal0231313 Rpn3[KK101504]   Drosophila melanogaster
FBal0287126 Rpn3[Scer\UAS.ORF]   Drosophila melanogaster
FBal0287127 Rpn3[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster

102 Clones

Secondary Identifier DB identifier
EK181161 FBcl0035524
EK138264 FBcl0035578
EK195561 FBcl0035696
EK258631 FBcl0035716
EK133811 FBcl0035758
EK084457 FBcl0037188
AT03667 FBcl0039769
AT16326 FBcl0039771
AT16090 FBcl0039775
AT11369 FBcl0039777
AT02685 FBcl0039787
AT03065 FBcl0039789
AT03656 FBcl0039791
AT10778 FBcl0039793
AT26795 FBcl0039795
AT01374 FBcl0039797
AT15146 FBcl0039801
AT10878 FBcl0039803
AT22910 FBcl0039805
AT19031 FBcl0039807
AT20752 FBcl0039809
AT29742 FBcl0039813
AT22773 FBcl0039815
AT13069 FBcl0039817
GH05246 FBcl0112989
GH17659 FBcl0112995
GM06481 FBcl0143315
GM08909 FBcl0143316
GM06383 FBcl0143317
GM06238 FBcl0143318

3 Exons

DB identifier Symbol
FBgn0261396:1 Rpn3:1
FBgn0261396:3 Rpn3:3
FBgn0261396:2 Rpn3:2

2 Transcripts

DB identifier Gene
FBtr0302289 Rpn3
FBtr0336843 Rpn3

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0336843-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0302289-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0336843-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0302289-3-prime-utr Drosophila melanogaster

Interactions

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74 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
35176 NCBI Entrez Gene identifiers FBgn0261396
61163 BioGRID FBgn0261396

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

2 Introns

DB identifier
Organism . Name
intron_FBgn0261396:1_FBgn0261396:3 Drosophila melanogaster
intron_FBgn0261396:2_FBgn0261396:3 Drosophila melanogaster

36 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Rpn3 none -0.044374441   19067489
Lipid storage Rpn3 none 2.249082635   19067489
Mitochondrial morphology Rpn3 Changes in mitochondria morphology np   18353969
ERK signaling Rpn3 ERK activation reduced weak   17086199
Cytokinesis regulation Rpn3 Binucleate cells with microtubule extensions weak   15547975
Imd pathway regulation Rpn3 Decreased Dipt::lacZ protein expression after lipopolysaccharide stimulation 4   15221030
Intracellular Listeria monocytogenes infection Rpn3 Decreased GFP protein expression moderate   16020693
Hedgehog signaling Rpn3 Decreased Hedgehog reporter activity -2.92   16311596
Constitutive protein secretion and Golgi organization (1) Rpn3 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Rpn3 Decreased G1 DNA content, decreased viability sp   16496002
Cell size and cell-cycle regulation (2) Rpn3 Decreased viability 0.782   16496002
Cell size and cell-cycle regulation (3) Rpn3 Decreased cell number 343   16496002
Cell size and cell-cycle regulation (4) Rpn3 none below threshold   16496002
Candida albicans phagocytosis (1) Rpn3 none np   16336044
Lipid storage Rpn3 Fewer lipid droplets strong   18408709
Mutant human huntingtin aggregation Rpn3 Decreased mutant human huntingtin aggregation <= -2   19789644
Heat nociception (1) Rpn3 Developmentally lethal 0   21074052
Heart development and function (1) Rpn3 none 1   20371351
Heart development and function (2) Rpn3 Decreased viability 3.37   20371351
Serratia marcescens infection (1) Rpn3 none 0.643835616438356   19520911
Notch pathway regulation (4) Rpn3 Completely lethal (before pupal) sp   19363474
Hh pathway regulation Rpn3 Downregulation of Hh pathway -0.440673514757508   17903264
Hh pathway regulation Rpn3 Downregulation of Hh pathway -0.36489782768785   17903264
Notch pathway regulation (1) Rpn3 Upregulation of Notch pathway np   20493818
Notch pathway regulation (2) Rpn3 Lethal strong en-GAL4 20493818
Notch pathway regulation (2) Rpn3 Lethal very strong en-GAL4 20493818
Notch pathway regulation (2) Rpn3 Downregulation of Notch pathway; adult wing margin: notches sp C96-GAL4 20493818
Notch pathway regulation (3) Rpn3 Only lethal with Notch np   20493818
Adiposity regulation (1) Rpn3 none -0.159   20074523
RTK-Ras-ERK pathway regulation (1) Rpn3 Decreased ERK phosphorylation after EGF stimulation -2.38 0 minutes EGF stimulation 22028469

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