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Gene : Roc1a D. melanogaster

DB identifier  ? FBgn0025638 Secondary Identifier  ? CG16982
Name  ? Roc1a Source  FlyBase
  • synonyms:
  • Rbx1,
  • dRoc1,
  • FBgn0025527,
  • BEST:CK01110,
  • CG16982,
  • CK01110,
  • Roc1alpha,
  • dRbx1,
  • ROC1,
  • EG:115C2.11,
  • FBan0016982,
  • dRoc1a,
  • FBgn0025705,
  • Roc1a,
  • anon-EST:Posey65,
  • FBgn0025638,
  • Rbx1/Roc

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12 Alleles

DB identifier Symbol Allele Class Organism
FBal0258431 Roc1a[grf.T:SV5\V5]   Drosophila melanogaster
FBal0248118 Roc1a[HMS00353]   Drosophila melanogaster
FBal0147541 Roc1a[N59R.C68R]   Drosophila melanogaster
FBal0147543 Roc1a[+tNa]   Drosophila melanogaster
FBal0181848 Roc1a[grf.Roc1b]   Drosophila melanogaster
FBal0147542 Roc1a[Hsp70.PN]   Drosophila melanogaster
FBal0181847 Roc1a[grf.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0181849 Roc1a[Scer\UAS.cDa]   Drosophila melanogaster
FBal0220042 Roc1a[G824]   Drosophila melanogaster
FBal0287316 Roc1a[Scer\UAS.ORF]   Drosophila melanogaster
FBal0208314 Roc1a[GD8596]   Drosophila melanogaster
FBal0235897 Roc1a[KK108885]   Drosophila melanogaster

42 Clones

Secondary Identifier DB identifier
ESG0111b.B21.1_G02 FBcl0000808
EK198840 FBcl0019828
EK211358 FBcl0015308
CK01110 FBcl0059791
EC31471 FBcl0067467
EC26074 FBcl0067471
EC39437 FBcl0067473
EC34118 FBcl0067475
EC32223 FBcl0067503
GH12110 FBcl0126765
GH22310 FBcl0127121
LP01687 FBcl0188090
LP13077 FBcl0188101
RE04714 FBcl0225959
RE61482 FBcl0225963
RE25951 FBcl0225971
RE60181 FBcl0225988
RE23848 FBcl0225990
RE20216 FBcl0225991
RE33466 FBcl0225993
RE37722 FBcl0225995
RE12188 FBcl0226011
SD23839 FBcl0284492
CK01.133A.F11 FBcl0406954
FGC022H05 FBcl0385805
FGC021A08 FBcl0385659
FGC027H12 FBcl0386179
FGC029E05 FBcl0386287
FGM228B10 FBcl0391278
FGH110A08 FBcl0387297

5 Exons

DB identifier Symbol
FBgn0025638:2 Roc1a:2
FBgn0025638:5 Roc1a:5
FBgn0025638:1 Roc1a:1
FBgn0025638:3 Roc1a:3
FBgn0025638:4 Roc1a:4

3 Transcripts

DB identifier Gene
FBtr0308651 Roc1a
FBtr0343564 Roc1a
FBtr0070122 Roc1a

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0308651-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0070122-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0343564-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0308651-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0070122-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0343564-3-prime-utr Drosophila melanogaster

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45 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
31014 NCBI Entrez Gene identifiers FBgn0025638
57582 BioGRID FBgn0025638

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 969.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1184.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1017.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1215.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 873.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1711.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 772.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 690.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 810.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 847.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1108.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 564.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 821.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 744.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1277.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 693.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 916.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 431.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1479.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1732.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 845.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1410.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1407.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1000.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1444.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2016.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2521.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 2202.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1202.0
FBgn0025638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1380.0

4 Introns

DB identifier
Organism . Name
intron_FBgn0025638:2_FBgn0025638:5 Drosophila melanogaster
intron_FBgn0025638:1_FBgn0025638:3 Drosophila melanogaster
intron_FBgn0025638:3_FBgn0025638:5 Drosophila melanogaster
intron_FBgn0025638:3_FBgn0025638:4 Drosophila melanogaster

23 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Roc1a Decreased lipid droplet area -3.668187739   19067489
Lipid storage Roc1a Decreased lipid droplet area -5.479845444   19067489
Constitutive protein secretion and Golgi organization (1) Roc1a Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Roc1a Increased G1 DNA content, decreased G2 DNA content, increased G1 cell size, increased G2 cell size sp   16496002
Cell size and cell-cycle regulation (2) Roc1a none 1.043   16496002
Cell size and cell-cycle regulation (3) Roc1a Decreased cell number 371   16496002
Cell size and cell-cycle regulation (4) Roc1a none below threshold   16496002
Muscle morphogenesis and function (1) Roc1a Lethal np   20220848
Muscle morphogenesis and function (1) Roc1a Lethal np   20220848
Muscle morphogenesis and function (2) Roc1a Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Heat nociception (1) Roc1a none -1.17   21074052
Heat nociception (1) Roc1a Developmentally lethal -1.17   21074052
Heart development and function (1) Roc1a none 1   20371351
Serratia marcescens infection (1) Roc1a none 0.453703703703703   19520911
Notch pathway regulation (4) Roc1a Completely lethal (before pupal) sp   19363474
Notch pathway regulation (4) Roc1a Completely lethal (before pupal) sp   19363474
Self-renewal and differentiation in neural stem cells Roc1a GFP aggregates number, GFP aggregates size, neuroblast less large cells, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with unchanged neuroblast cell size, neuroblast underproliferation, lethal sp   21549331
Adiposity regulation (1) Roc1a none -0.152   20074523
RTK-Ras-ERK pathway regulation (1) Roc1a none 0.53 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Roc1a none -1.22 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Roc1a Increased ERK phosphorylation after sSpitz and EGF stimulation 2.36 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Roc1a Increased ERK phosphorylation after sSpitz and EGF stimulation 2.77 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation Roc1a none -0.12   23263283

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