modENCODE |  Help |  blog

Gene : Hel25E D. melanogaster

DB identifier  ? FBgn0014189 Secondary Identifier  ? CG7269
Name  ? Helicase at 25E Source  FlyBase
  • synonyms:
  • Hel25E,
  • sz,
  • jf26,
  • lethal(2)25Eb,
  • CG7269,
  • l(2)25Eb,
  • UAP56,
  • FBgn0001929,
  • WM6,
  • FBgn0014189,
  • l(2)jf26,
  • Dbp25F,
  • helicase,
  • FBgn0021910,
  • l(2)k11511,
  • FBgn0008648,
  • DmRH4,
  • l(2)gdh-12,
  • l(2)gdh12,
  • FBan0007269,
  • HEL,
  • RNA helicase

Sequence Feature Displayer

Publication Counts Displayer

Genomics

Gene Ontology Displayer

Homologue Displayer

Mod Mine G Browse Displayer

Overlapping Features Displayer

Regulatory Regions Displayer

13 Alleles

DB identifier Symbol Allele Class Organism
FBal0257107 Hel25E[HMS00076]   Drosophila melanogaster
FBal0183318 Hel25E[c02934]   Drosophila melanogaster
FBal0162314 Hel25E[e02545]   Drosophila melanogaster
FBal0064166 Hel25E[k11511]   Drosophila melanogaster
FBal0008351 Hel25E[3] loss of function allele Drosophila melanogaster
FBal0063230 Hel25E[+t4.5]   Drosophila melanogaster
FBal0150796 Hel25E[dsRNA.cHa]   Drosophila melanogaster
FBal0008349 Hel25E[1]   Drosophila melanogaster
FBal0128186 Hel25E[dsRNA.N]   Drosophila melanogaster
FBal0008350 Hel25E[2]   Drosophila melanogaster
FBal0207278 Hel25E[GD12189]   Drosophila melanogaster
FBal0236151 Hel25E[KK109227]   Drosophila melanogaster
FBal0275502 Hel25E[NIG.7269R]   Drosophila melanogaster

200 Clones

Secondary Identifier DB identifier
EK059237 FBcl0029198
ESG0112c.B21_G03 FBcl0001549
EK259443 FBcl0029262
EK250961 FBcl0029272
EK267819 FBcl0029278
EK260961 FBcl0029290
EK058057 FBcl0029306
EK276327 FBcl0029360
EK028947 FBcl0029370
EK164101 FBcl0029380
EK200026 FBcl0029636
EK031205 FBcl0029730
EK150029 FBcl0029774
EK229346 FBcl0030170
AT16734 FBcl0022791
EC43555 FBcl0066531
EP11913 FBcl0080755
GM01003 FBcl0141233
GM10311 FBcl0141235
GM06295 FBcl0141271
GM10461 FBcl0141287
GM04380 FBcl0141289
GM02511 FBcl0141295
GM03443 FBcl0141297
GM15539 FBcl0145855
GM31377 FBcl0145944
GM30789 FBcl0145949
LD14404 FBcl0161325
LD02472 FBcl0161331
LD09403 FBcl0161333

13 Exons

DB identifier Symbol
FBgn0014189:13 Hel25E:13
FBgn0014189:10 Hel25E:10
FBgn0014189:9 Hel25E:9
FBgn0014189:8 Hel25E:8
FBgn0014189:7 Hel25E:7
FBgn0014189:5 Hel25E:5
FBgn0014189:4 Hel25E:4
FBgn0014189:1 Hel25E:1
FBgn0014189:11 Hel25E:11
FBgn0014189:3 Hel25E:3
FBgn0014189:12 Hel25E:12
FBgn0014189:6 Hel25E:6
FBgn0014189:2 Hel25E:2

4 Transcripts

DB identifier Gene
FBtr0079125 Hel25E
FBtr0331676 Hel25E
FBtr0079124 Hel25E
FBtr0079123 Hel25E

8 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0079123-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0079124-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0079125-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0331676-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079123-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079124-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079125-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0331676-3-prime-utr Drosophila melanogaster

Interactions

Cytoscape Network Displayer

 

Other

0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
33781 NCBI Entrez Gene identifiers FBgn0014189
59949 BioGRID FBgn0014189

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 4858.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 4747.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 4038.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 4331.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 3602.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1461.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1445.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 2768.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1240.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 3558.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 2727.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1992.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1989.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 3448.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 2280.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 2349.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 2570.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2150.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 2180.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 2845.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 3277.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 4024.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 2849.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 2776.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2265.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 6283.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 6438.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 5901.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 4707.0
FBgn0014189 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 5198.0

14 Introns

DB identifier
Organism . Name
intron_FBgn0014189:12_FBgn0014189:9 Drosophila melanogaster
intron_FBgn0014189:9_FBgn0014189:8 Drosophila melanogaster
intron_FBgn0014189:8_FBgn0014189:7 Drosophila melanogaster
intron_FBgn0014189:7_FBgn0014189:5 Drosophila melanogaster
intron_FBgn0014189:5_FBgn0014189:4 Drosophila melanogaster
intron_FBgn0014189:4_FBgn0014189:1 Drosophila melanogaster
intron_FBgn0014189:13_FBgn0014189:11 Drosophila melanogaster
intron_FBgn0014189:11_FBgn0014189:9 Drosophila melanogaster
intron_FBgn0014189:8_FBgn0014189:6 Drosophila melanogaster
intron_FBgn0014189:6_FBgn0014189:4 Drosophila melanogaster
intron_FBgn0014189:4_FBgn0014189:2 Drosophila melanogaster
intron_FBgn0014189:13_FBgn0014189:10 Drosophila melanogaster
intron_FBgn0014189:10_FBgn0014189:9 Drosophila melanogaster
intron_FBgn0014189:4_FBgn0014189:3 Drosophila melanogaster

37 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Hel25E none -2.88482458   19067489
Lipid storage Hel25E none 0.382626262   19067489
ERK signaling Hel25E ERK activation reduced strong   17086199
Alternative splicing Hel25E Alternative Dscam (exon 4 and exon 17) splicing sp   15492211
Intracellular Listeria monocytogenes infection Hel25E Decreased GFP protein expression moderate   16020693
Innate immunity Hel25E Decreased IMD/Rel reporter activity -6.7   16170305
Hedgehog signaling Hel25E Decreased Hedgehog reporter activity -3.34   16311596
Constitutive protein secretion and Golgi organization (1) Hel25E Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Hel25E none sp   16496002
Candida albicans phagocytosis (1) Hel25E none np   16336044
Mitosis Hel25E Chromosome misalignment np   17412918
Mitochondrial biogenesis and function Hel25E Increased mitochondrial citrate synthase activity, decreased viability 1.709   18042644
Lipid storage Hel25E Altered total signal automated analysis   18408709
Mutant human huntingtin aggregation Hel25E Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) Hel25E Lethal np   20220848
Muscle morphogenesis and function (1) Hel25E Lethal np   20220848
Muscle morphogenesis and function (3) Hel25E Clumpy Z-line (irregular aggregates) np   20220848
Heat nociception (1) Hel25E Developmentally lethal -1.17   21074052
Heart development and function (1) Hel25E Adult lethal 0.6   20371351
Heart development and function (2) Hel25E Decreased viability 3.39   20371351
Serratia marcescens infection (1) Hel25E none -0.639344262295081   19520911
Notch pathway regulation (4) Hel25E Completely lethal (pupal) sp   19363474
Notch pathway regulation (4) Hel25E Completely lethal (before pupal) sp   19363474
PGN-induced dJNK phosphorylation Hel25E Decreased P-JNK protein expression with PGN -2.01 15 min PGN induction 19893628
Hh pathway regulation Hel25E Downregulation of Hh pathway -0.31726504192988   17903264
Hh pathway regulation Hel25E none -0.0856555394679892   17903264
Pol II elongation Hel25E Decreased Hsp70 mRNA expression 62 20 min heat shock 19279664
Adiposity regulation (1) Hel25E none -0.741   20074523
RTK-Ras-ERK pathway regulation (1) Hel25E Increased ERK phosphorylation after EGF stimulation 3.25 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Hel25E Decreased ERK phosphorylation after EGF stimulation -3.5 10 minutes EGF stimulation 22028469

0 Submissions