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Gene : InR D. melanogaster

DB identifier  ? FBgn0013984 Secondary Identifier  ? CG18402
Name  ? Insulin-like receptor Source  FlyBase
  • synonyms:
  • lethal(3)93Dj,
  • CG18402,
  • FBgn0000456,
  • FBgn0000457,
  • DInR,
  • er10,
  • l(3)er10,
  • Insulin-like Receptor,
  • Dir-a,
  • Insulin Receptor,
  • FBgn0013984,
  • DIRH,
  • Drosophila Insulin Receptor,
  • DIHR,
  • IR,
  • FBgn0010868,
  • insulin receptor homologue,
  • InsR,
  • FBan0018402,
  • Inr-alpha,
  • Insulin-receptor,
  • Insulin,
  • DIRbeta,
  • l(3)93Dj,
  • lnR,
  • Dir-b,
  • l(3)05545,
  • dInsR,
  • DILR,
  • INR,
  • insulin/insulin-like growth factor receptor,
  • INS,
  • DIR,
  • Inr-beta,
  • 18402,
  • FBgn0002393,
  • insulin receptor homolog

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95 Alleles

DB identifier Symbol Allele Class Organism
FBal0264326 InR[NIG.18402R]   Drosophila melanogaster
FBal0284595 InR[Scer\UAS.cUa]   Drosophila melanogaster
FBal0284603 InR[GS15311]   Drosophila melanogaster
FBal0284604 InR[GS50346]   Drosophila melanogaster
FBal0245475 InR[JF01183]   Drosophila melanogaster
FBal0245746 InR[JF01482]   Drosophila melanogaster
FBal0009539 InR[05545] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0198008 InR[act.Scer\UAS]   Drosophila melanogaster
FBal0279771 InR[MI07152]   Drosophila melanogaster
FBal0244102 InR[34]   Drosophila melanogaster
FBal0122080 InR[339]   Drosophila melanogaster
FBal0176094 InR[ex52.1]   Drosophila melanogaster
FBal0042647 InR[hs.PF]   Drosophila melanogaster
FBal0094022 InR[E16]   Drosophila melanogaster
FBal0042630 InR[167] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0042644 InR[76] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0094021 InR[E19]   Drosophila melanogaster
FBal0156353 InR[sev.Exel]   Drosophila melanogaster
FBal0156355 InR[del.GMR]   Drosophila melanogaster
FBal0156358 InR[R418P.GMR]   Drosophila melanogaster
FBal0156360 InR[K1409A.GMR] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0156361 InR[GMR.Exel]   Drosophila melanogaster
FBal0156363 InR[A1325D.GMR] gain of function allele Drosophila melanogaster
FBal0042636 InR[301] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0042633 InR[242] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0122081 InR[304]   Drosophila melanogaster
FBal0122079 InR[unspecified]   Drosophila melanogaster
FBal0042642 InR[35] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0042637 InR[306] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0010756 InR[93Dj-5]   Drosophila melanogaster

57 Clones

Secondary Identifier DB identifier
EK064821 FBcl0072650
EK156239 FBcl0072820
EK148621 FBcl0072828
EK095024 FBcl0072834
EK296349 FBcl0072860
EK168235 FBcl0072862
EK293133 FBcl0072866
EK073019 FBcl0072872
EK075861 FBcl0072876
EK265829 FBcl0072878
EK295151 FBcl0072882
EK262936 FBcl0072894
EK071061 FBcl0072898
EK175426 FBcl0072902
EK191832 FBcl0072932
EK207355 FBcl0073114
EK107720 FBcl0073152
EK108320 FBcl0073170
EP22029 FBcl0085343
EP03207 FBcl0085347
EP21806 FBcl0085423
EP16953 FBcl0085767
HL04822 FBcl0149959
LD06045 FBcl0159345
RH70738 FBcl0263900
SD18256 FBcl0287643
EC054426 FBcl0300100
EC051410 FBcl0300101
EC053913 FBcl0300102
EC055262 FBcl0300103

16 Exons

DB identifier Symbol
FBgn0013984:15 InR:15
FBgn0013984:14 InR:14
FBgn0013984:11 InR:11
FBgn0013984:10 InR:10
FBgn0013984:9 InR:9
FBgn0013984:8 InR:8
FBgn0013984:7 InR:7
FBgn0013984:6 InR:6
FBgn0013984:5 InR:5
FBgn0013984:4 InR:4
FBgn0013984:3 InR:3
FBgn0013984:2 InR:2
FBgn0013984:1 InR:1
FBgn0013984:16 InR:16
FBgn0013984:13 InR:13
FBgn0013984:12 InR:12

4 Transcripts

DB identifier Gene
FBtr0290231 InR
FBtr0290232 InR
FBtr0084121 InR
FBtr0290230 InR

8 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0084121-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0290230-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0290231-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0290232-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0084121-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0290230-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0290231-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0290232-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
42549 NCBI Entrez Gene identifiers FBgn0013984
67515 BioGRID FBgn0013984

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 455.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 701.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 665.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 455.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 207.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1007.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 2090.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 927.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 722.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1210.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1044.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 351.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1025.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 554.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 501.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 572.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 742.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 661.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 582.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 709.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 788.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 439.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 353.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1464.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1385.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 525.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 758.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 881.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 781.0
FBgn0013984 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 677.0

15 Introns

DB identifier
Organism . Name
intron_FBgn0013984:15_FBgn0013984:14 Drosophila melanogaster
intron_FBgn0013984:14_FBgn0013984:11 Drosophila melanogaster
intron_FBgn0013984:11_FBgn0013984:10 Drosophila melanogaster
intron_FBgn0013984:10_FBgn0013984:9 Drosophila melanogaster
intron_FBgn0013984:9_FBgn0013984:8 Drosophila melanogaster
intron_FBgn0013984:8_FBgn0013984:7 Drosophila melanogaster
intron_FBgn0013984:7_FBgn0013984:6 Drosophila melanogaster
intron_FBgn0013984:6_FBgn0013984:5 Drosophila melanogaster
intron_FBgn0013984:5_FBgn0013984:4 Drosophila melanogaster
intron_FBgn0013984:4_FBgn0013984:3 Drosophila melanogaster
intron_FBgn0013984:3_FBgn0013984:2 Drosophila melanogaster
intron_FBgn0013984:2_FBgn0013984:1 Drosophila melanogaster
intron_FBgn0013984:16_FBgn0013984:14 Drosophila melanogaster
intron_FBgn0013984:13_FBgn0013984:11 Drosophila melanogaster
intron_FBgn0013984:12_FBgn0013984:11 Drosophila melanogaster

40 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation InR none -0.38   19216764
Lipid storage InR none 0.087543514   19067489
Lipid storage InR none 1.496235818   19067489
Neural outgrowth InR Cell loss np   18604272
ERK signaling InR ERK activation reduced strong   17086199
Cell cycle regulation (1) InR Decreased number of cells in prometaphase and metaphase sp   15616552
Cell cycle regulation (2) InR none np   15616552
Cell size and cell-cycle regulation (1) InR none sp   16496002
Combinatorial effect with methyl methanesulphonate (2) InR Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) InR Weak flyer np   20220848
Muscle morphogenesis and function (1) InR Lethal np   20220848
Muscle morphogenesis and function (1) InR Lethal np   20220848
Heat nociception (1) InR none -1.17   21074052
Heart development and function (1) InR none 1   20371351
Serratia marcescens infection (1) InR none 0.8   19520911
Serratia marcescens infection (1) InR none 1.41095890410958   19520911
Notch pathway regulation (4) InR Bristle morphology defects 10   19363474
Notch pathway regulation (4) InR Bristle morphology defects 8   19363474
Notch pathway regulation (4) InR Bristle morphology defects 10   19363474
Akt-TOR pathway negative feedback regulation InR Decreased dAkt phosphorylation after insulin stimulation -6.8 10 min insulin stimulation 20585550
Adiposity regulation (1) InR Decreased triglyceride expression -0.57   20074523
Adiposity regulation (2) InR none -0.05   20074523
Adiposity regulation (3) InR none -0.194   20074523
Adiposity regulation (4) InR none 0.188   20074523
Adiposity regulation (5) InR Decreased triglyceride expression -0.653   20074523
Blood cell homeostasis regulation (1) InR none np   20540764
Blood cell homeostasis regulation (2) InR none np   20540764
Actin organization and cell morphology (1) InR none np   19265526
Actin organization and cell morphology (2) InR none np   19265526
Actin organization and cell morphology (3) InR none np   19265526

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