Genomics
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9 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0257103 | Rpn11[HMS00071] | Drosophila melanogaster | |
| FBal0181776 | Rpn11[f00396] | Drosophila melanogaster | |
| FBal0161728 | Rpn11[f00386] | Drosophila melanogaster | |
| FBal0155939 | Rpn11[BG01694] | Drosophila melanogaster | |
| FBal0286835 | Rpn11[Scer\UAS.ORF] | Drosophila melanogaster | |
| FBal0286836 | Rpn11[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0208407 | Rpn11[GD8888] | Drosophila melanogaster | |
| FBal0222838 | Rpn11[d07228] | Drosophila melanogaster | |
| FBal0272808 | Rpn11[NIG.18174R] | Drosophila melanogaster |
45 Clones
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0079027-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0079027-3-prime-utr | Drosophila melanogaster |
Other
74 Pathways
- Signaling Pathways,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- Class I MHC mediated antigen processing & presentation,
- Cell Cycle,
- DNA Repair,
- Separation of Sister Chromatids,
- G1/S DNA Damage Checkpoints,
- Regulation of Apoptosis,
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- Regulation of APC/C activators between G1/S and early anaphase,
- Signaling by Wnt,
- Mitotic G1-G1/S phases,
- Immune System,
- ATM mediated response to DNA double-strand break,
- Regulation of DNA replication,
- Synthesis of DNA,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- Apoptosis,
- Antigen processing: Ubiquitination & Proteasome degradation,
- Amplification of signal from the kinetochores,
- Mitotic Metaphase and Anaphase,
- Adaptive Immune System,
- APC/C-mediated degradation of cell cycle proteins,
- G2/M Checkpoints,
- Mitotic G2-G2/M phases,
- Regulation of mitotic cell cycle,
- Double-Strand Break Repair,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- Autodegradation of Cdh1 by Cdh1:APC/C,
- Homologous Recombination Repair,
- Cell Cycle, Mitotic,
- Activation of NF-kappaB in B Cells,
- G2/M DNA replication checkpoint,
- S Phase,
- DNA Replication,
- Orc1 removal from chromatin,
- CDK-mediated phosphorylation and removal of Cdc6,
- G1/S Transition,
- ER-Phagosome pathway,
- M/G1 Transition,
- B Cell Activation,
- p53-Independent G1/S DNA damage checkpoint,
- Removal of licensing factors from origins,
- Mitotic Spindle Checkpoint,
- Downstream Signaling Events Of B Cell Receptor (BCR),
- Polo-like kinase mediated events,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- APC/C:Cdc20 mediated degradation of Securin,
- M Phase,
- Cross-presentation of soluble exogenous antigens (endosomes),
- SCF-beta-TrCP mediated degradation of Emi1,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- Degradation of beta-catenin by the destruction complex,
- Cyclin A:Cdk2-associated events at S phase entry,
- DNA Replication Pre-Initiation,
- Homologous recombination repair of replication-independent double-strand breaks,
- Beta-catenin phosphorylation cascade,
- Cell Cycle Checkpoints,
- G2/M Transition,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- Switching of origins to a post-replicative state,
- Antigen processing-Cross presentation,
- Cyclin A/B1 associated events during G2/M transition,
- Cyclin E associated events during G1/S transition,
- Mitotic M-M/G1 phases,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- Regulation of activated PAK-2p34 by proteasome mediated degradation,
- Mitotic Anaphase,
- SCF(Skp2)-mediated degradation of p27/p21,
- p53-Independent DNA Damage Response,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- G2/M DNA damage checkpoint
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 33738 | NCBI Entrez Gene identifiers | FBgn0028694 |
| 59913 | BioGRID | FBgn0028694 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
2 Introns
| DB identifier |
Organism . Name |
|---|---|
| intron_FBgn0028694:3_FBgn0028694:2 | Drosophila melanogaster |
| intron_FBgn0028694:2_FBgn0028694:1 | Drosophila melanogaster |
33 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | Rpn11 | none | -0.374140606 | 19067489 | |
| Lipid storage | Rpn11 | none | 1.842672883 | 19067489 | |
| ERK signaling | Rpn11 | ERK activation reduced | weak | 17086199 | |
| Intracellular Listeria monocytogenes infection | Rpn11 | Decreased GFP protein expression | moderate | 16020693 | |
| Hedgehog signaling | Rpn11 | Decreased Hedgehog reporter activity | -2.82 | 16311596 | |
| Constitutive protein secretion and Golgi organization (1) | Rpn11 | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
| Cell size and cell-cycle regulation (1) | Rpn11 | Decreased viability | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | Rpn11 | Decreased viability | 0.911 | 16496002 | |
| Cell size and cell-cycle regulation (3) | Rpn11 | none | 481 | 16496002 | |
| Candida albicans phagocytosis (1) | Rpn11 | none | np | 16336044 | |
| Combinatorial effect with methyl methanesulphonate (2) | Rpn11 | none | sp | 19543366 | |
| Mutant human huntingtin aggregation | Rpn11 | Decreased mutant human huntingtin aggregation | <= -2 | 19789644 | |
| Muscle morphogenesis and function (1) | Rpn11 | Lethal | np | 20220848 | |
| Heat nociception (1) | Rpn11 | Developmentally lethal | -0.77 | 21074052 | |
| Heat nociception (1) | Rpn11 | none | -0.52 | 21074052 | |
| Regulated secretory pathway biogenesis (1) | Rpn11 | none | -0.9 | 21149569 | |
| Heart development and function (1) | Rpn11 | none | 0.69 | 20371351 | |
| Heart development and function (2) | Rpn11 | Decreased viability | 3.08 | 20371351 | |
| Serratia marcescens infection (1) | Rpn11 | none | 0.243589743589743 | 19520911 | |
| Notch pathway regulation (4) | Rpn11 | Completely lethal (before pupal) | sp | 19363474 | |
| Notch pathway regulation (4) | Rpn11 | none | 0 | 19363474 | |
| Hh pathway regulation | Rpn11 | Downregulation of Hh pathway | -0.390454864256852 | 17903264 | |
| Hh pathway regulation | Rpn11 | Downregulation of Hh pathway | -0.265773099597837 | 17903264 | |
| Adiposity regulation (1) | Rpn11 | none | -0.395 | 20074523 | |
| Blood cell homeostasis regulation (1) | Rpn11 | none | np | 20540764 | |
| Blood cell homeostasis regulation (2) | Rpn11 | none | np | 20540764 | |
| S2 cell spreading | Rpn11 | none | np | 21041442 | |
| RTK-Ras-ERK pathway regulation (1) | Rpn11 | Decreased ERK phosphorylation after EGF stimulation | -4.99 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | Rpn11 | Decreased ERK phosphorylation after EGF stimulation | -3.42 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Rpn11 | none | -0.45 | 10 minutes sSpitz stimulation | 22028469 |
