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Gene : Hsc70-3 D. melanogaster

DB identifier  ? FBgn0001218 Secondary Identifier  ? CG4147
Name  ? Heat shock 70-kDa protein cognate 3 Source  FlyBase
  • synonyms:
  • l(1)G0466,
  • heat shock cognate protein 3,
  • dBiP,
  • HSC3,
  • dhsc70,
  • hsc72,
  • CG4147,
  • A4V4C4_DROME,
  • FBgn0027308,
  • heat shock protein cognate 72,
  • l(1)G0102,
  • l(1)G0407,
  • FBgn0028330,
  • l(1)G0341,
  • Hsp-c3,
  • Hsc-3,
  • FBgn0044787,
  • l(1)G0292,
  • HSC70,
  • FBgn0001218,
  • FBgn0040174,
  • Grp78,
  • anon-WO0138581.7,
  • l(1)G0111,
  • FBgn0028286,
  • Hsc-70-3,
  • HSP7C_DROME,
  • Hsc3p,
  • HSC70-3,
  • Heat shock 70-kDa protein cognate 3,
  • immunoglobulin binding protein,
  • FBgn0030335,
  • FBan0004147,
  • dmHsc72,
  • FBgn0029049,
  • CG1579,
  • FBgn0027310,
  • Heat shock protein cognate 3,
  • BiP,
  • HSC-70

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43 Alleles

DB identifier Symbol Allele Class Organism
FBal0267559 Hsc70-3[GS1150]   Drosophila melanogaster
FBal0183185 Hsc70-3[d04969]   Drosophila melanogaster
FBal0183186 Hsc70-3[d04173]   Drosophila melanogaster
FBal0183187 Hsc70-3[d03307]   Drosophila melanogaster
FBal0183188 Hsc70-3[d01672]   Drosophila melanogaster
FBal0160307 Hsc70-3[EY11233]   Drosophila melanogaster
FBal0183189 Hsc70-3[d01593]   Drosophila melanogaster
FBal0156376 Hsc70-3[EP336b]   Drosophila melanogaster
FBal0098201 Hsc70-3[G0111]   Drosophila melanogaster
FBal0098203 Hsc70-3[G0102]   Drosophila melanogaster
FBal0100278 Hsc70-3[G0407]   Drosophila melanogaster
FBal0100322 Hsc70-3[G0292]   Drosophila melanogaster
FBal0152453 Hsc70-3[G0466b]   Drosophila melanogaster
FBal0103745 Hsc70-3[G0341]   Drosophila melanogaster
FBal0130988 Hsc70-3[PG86]   Drosophila melanogaster
FBal0130989 Hsc70-3[PG84]   Drosophila melanogaster
FBal0130990 Hsc70-3[PG6]   Drosophila melanogaster
FBal0130991 Hsc70-3[PG65]   Drosophila melanogaster
FBal0130992 Hsc70-3[PG39]   Drosophila melanogaster
FBal0130993 Hsc70-3[PG34]   Drosophila melanogaster
FBal0130994 Hsc70-3[PG119]   Drosophila melanogaster
FBal0130985 Hsc70-3[PL73]   Drosophila melanogaster
FBal0130986 Hsc70-3[PL68]   Drosophila melanogaster
FBal0130987 Hsc70-3[PL11]   Drosophila melanogaster
FBal0060648 Hsc70-3[D231S.Scer\UAS]   Drosophila melanogaster
FBal0060647 Hsc70-3[K97S.Scer\UAS]   Drosophila melanogaster
FBal0098845 Hsc70-3[Scer\UAS.cEa]   Drosophila melanogaster
FBal0212810 Hsc70-3[EP1507]   Drosophila melanogaster
FBal0287487 Hsc70-3[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0194906 Hsc70-3[dsRNA.cDa]   Drosophila melanogaster

330 Clones

Secondary Identifier DB identifier
EC24136 FBcl0062243
EC03301 FBcl0062245
EC39818 FBcl0062253
EC40086 FBcl0062269
EC39727 FBcl0062283
EC40527 FBcl0062285
EC03601 FBcl0062623
EN02905 FBcl0091713
EN02531 FBcl0091879
EN10654 FBcl0091897
EK062944 FBcl0128470
EK196142 FBcl0128500
EK303417 FBcl0128522
EK256311 FBcl0128534
EK065306 FBcl0128538
EK185862 FBcl0128544
EK174904 FBcl0128548
EK167743 FBcl0128552
EK114825 FBcl0128558
EK235222 FBcl0128568
EK293628 FBcl0128582
EK258833 FBcl0128590
EK192410 FBcl0128594
EK251546 FBcl0128598
EK267058 FBcl0128602
EK144837 FBcl0128606
EK100242 FBcl0128610
EK043325 FBcl0128614
EK245217 FBcl0128618
EK191116 FBcl0128622

6 Exons

DB identifier Symbol
FBgn0001218:6 Hsc70-3:6
FBgn0001218:2 Hsc70-3:2
FBgn0001218:1 Hsc70-3:1
FBgn0001218:5 Hsc70-3:5
FBgn0001218:4 Hsc70-3:4
FBgn0001218:3 Hsc70-3:3

4 Transcripts

DB identifier Gene
FBtr0073608 Hsc70-3
FBtr0073609 Hsc70-3
FBtr0073611 Hsc70-3
FBtr0073610 Hsc70-3

8 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0073608-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0073609-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0073610-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0073611-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0073608-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0073609-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0073610-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0073611-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
32133 NCBI Entrez Gene identifiers FBgn0001218
58539 BioGRID FBgn0001218

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 8959.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 10118.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 4908.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 7900.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 5637.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 5117.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 6794.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 6313.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 5103.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 3928.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 5692.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 3859.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 6634.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 3004.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 6149.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 5806.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 6245.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 5861.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 4515.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 7003.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 6311.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 10696.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 5596.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 6024.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 4521.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 7594.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 4082.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1862.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 2790.0
FBgn0001218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 3854.0

5 Introns

DB identifier
Organism . Name
intron_FBgn0001218:6_FBgn0001218:2 Drosophila melanogaster
intron_FBgn0001218:2_FBgn0001218:1 Drosophila melanogaster
intron_FBgn0001218:5_FBgn0001218:2 Drosophila melanogaster
intron_FBgn0001218:4_FBgn0001218:2 Drosophila melanogaster
intron_FBgn0001218:3_FBgn0001218:2 Drosophila melanogaster

30 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Hsc70-3 Increased lipid droplet area 3.32309784   19067489
Lipid storage Hsc70-3 Increased lipid droplet area 4.57689168   19067489
Lipid storage Hsc70-3 Increased lipid droplet area 8.159997536   19067489
Intracellular Listeria monocytogenes infection Hsc70-3 Increased GFP protein expression moderate   16020693
Constitutive protein secretion and Golgi organization (1) Hsc70-3 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Hsc70-3 Decreased G1 DNA content sp   16496002
Cell size and cell-cycle regulation (1) Hsc70-3 none sp   16496002
Cell size and cell-cycle regulation (2) Hsc70-3 none 1.152   16496002
Cell size and cell-cycle regulation (3) Hsc70-3 none 455   16496002
Cell size and cell-cycle regulation (4) Hsc70-3 Increased number of mitotic cells 1   16496002
RNAi pathway Hsc70-3 Decreased RNAi effect 25   16882716
Brucella melitensis infection Hsc70-3 none 95.2   18654626
Influenza replication Hsc70-3 Decreased Influenza replication -3.01/-2.53   18615016
Mitochondrial biogenesis and function Hsc70-3 Decreased mitochondrial citrate synthase activity 0.714   18042644
Muscle morphogenesis and function (1) Hsc70-3 Lethal np   20220848
Muscle morphogenesis and function (1) Hsc70-3 Lethal np   20220848
Muscle morphogenesis and function (2) Hsc70-3 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Heat nociception (1) Hsc70-3 none -0.1   21074052
Heat nociception (1) Hsc70-3 none -1.17   21074052
Heart development and function (1) Hsc70-3 none 1   20371351
Serratia marcescens infection (1) Hsc70-3 none 0.305555555555555   19520911
Notch pathway regulation (4) Hsc70-3 Completely lethal (before pupal) sp   19363474
Notch pathway regulation (4) Hsc70-3 Completely lethal (before pupal) sp   19363474
Adiposity regulation (1) Hsc70-3 none -0.667   20074523
RTK-Ras-ERK pathway regulation (1) Hsc70-3 none 1.03 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Hsc70-3 none -1.35 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Hsc70-3 Increased ERK phosphorylation after sSpitz and EGF stimulation 2.67 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Hsc70-3 Increased ERK phosphorylation after sSpitz and EGF stimulation 3.74 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation Hsc70-3 none -2.11   23263283
Huntingtin (Htt) aggregates formation Hsc70-3 Decreased formation of mutant Huntingtin (Httex1-Qn) protein aggregates np   20100940

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