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Gene : lok D. melanogaster

DB identifier  ? FBgn0019686 Secondary Identifier  ? CG10895
Name  ? loki Source  FlyBase
  • synonyms:
  • FBgn0019686,
  • MNK,
  • unnamed,
  • localized ovarian kinase,
  • Dmnk-L,
  • DmCHk2,
  • FBan0010895,
  • 38B.4,
  • CHK-2,
  • Dmnk/DChk2,
  • chk,
  • loki,
  • Dmnk,
  • CHK2,
  • CG10895,
  • 10895,
  • Drosophila maternal nuclear kinase,
  • lok,
  • LOKI/CHK2,
  • Dmnk-S,
  • maternal nuclear kinase,
  • chk2/lok,
  • Checkpoint kinase 2

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18 Alleles

DB identifier Symbol Allele Class Organism
FBal0280231 lok[Scer\UAS.cPb]   Drosophila melanogaster
FBal0280232 lok[D286A.Scer\UAS]   Drosophila melanogaster
FBal0284055 lok[GUS.cBa]   Drosophila melanogaster
FBal0284056 lok[kd.GUS]   Drosophila melanogaster
FBal0220454 lok[unspecified]   Drosophila melanogaster
FBal0258829 lok[KK100813]   Drosophila melanogaster
FBal0248730 lok[Scer\UAS.P\T.T:Ivir\HA1]   Drosophila melanogaster
FBal0129248 lok[E51]   Drosophila melanogaster
FBal0129247 lok[hs.PX]   Drosophila melanogaster
FBal0143333 lok[+tBa]   Drosophila melanogaster
FBal0147041 lok[5'.tMa]   Drosophila melanogaster
FBal0147042 lok[3'.tMa]   Drosophila melanogaster
FBal0262511 lok[GL00020]   Drosophila melanogaster
FBal0197286 lok[30]   Drosophila melanogaster
FBal0147040 lok[D303A.Scer\UAS]   Drosophila melanogaster
FBal0147039 lok[Scer\UAS.cPa]   Drosophila melanogaster
FBal0209937 lok[GD4190]   Drosophila melanogaster
FBal0216721 lok[p6] loss of function allele Drosophila melanogaster

59 Clones

Secondary Identifier DB identifier
EK196738 FBcl0087930
EK245916 FBcl0087960
EK175001 FBcl0087996
LD01443 FBcl0154878
LD31503 FBcl0168265
LD27857 FBcl0168266
RE21120 FBcl0207490
RE72126 FBcl0207499
RE11565 FBcl0207502
RE43681 FBcl0207503
RE43616 FBcl0207507
RE42285 FBcl0207508
RE36409 FBcl0207512
RE38730 FBcl0207514
RE04305 FBcl0207520
SD23521 FBcl0281761
SD22085 FBcl0281762
SD26335 FBcl0281766
SD03432 FBcl0281770
SD22219 FBcl0281790
EC051973 FBcl0301468
EC054478 FBcl0301469
EC054979 FBcl0301470
EC056308 FBcl0301471
117459 FBcl0405840
Dmel_neb_011285_0837_1576 FBcl0375190
RM07993 FBcl0375169
RM08093 FBcl0375170
RM08193 FBcl0375171
RM07793 FBcl0375172

12 Exons

DB identifier Symbol
FBgn0019686:1 lok:1
FBgn0019686:5 lok:5
FBgn0019686:6 lok:6
FBgn0019686:7 lok:7
FBgn0019686:8 lok:8
FBgn0019686:10 lok:10
FBgn0019686:12 lok:12
FBgn0019686:2 lok:2
FBgn0019686:4 lok:4
FBgn0019686:3 lok:3
FBgn0019686:11 lok:11
FBgn0019686:9 lok:9

4 Transcripts

DB identifier Gene
FBtr0081328 lok
FBtr0306234 lok
FBtr0081330 lok
FBtr0081329 lok

8 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0081328-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0081329-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0081330-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0306234-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081328-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081329-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081330-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0306234-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
35288 NCBI Entrez Gene identifiers FBgn0019686
61259 BioGRID FBgn0019686

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1296.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1266.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1421.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1819.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1647.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1206.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1173.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1871.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 884.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2575.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1758.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 991.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1384.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 2294.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1403.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1201.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1017.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1373.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1491.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 739.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1666.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1645.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1067.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1132.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2087.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 13044.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 5455.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 3607.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 2221.0
FBgn0019686 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1753.0

12 Introns

DB identifier
Organism . Name
intron_FBgn0019686:1_FBgn0019686:5 Drosophila melanogaster
intron_FBgn0019686:5_FBgn0019686:6 Drosophila melanogaster
intron_FBgn0019686:6_FBgn0019686:7 Drosophila melanogaster
intron_FBgn0019686:7_FBgn0019686:8 Drosophila melanogaster
intron_FBgn0019686:8_FBgn0019686:10 Drosophila melanogaster
intron_FBgn0019686:10_FBgn0019686:12 Drosophila melanogaster
intron_FBgn0019686:2_FBgn0019686:4 Drosophila melanogaster
intron_FBgn0019686:4_FBgn0019686:6 Drosophila melanogaster
intron_FBgn0019686:3_FBgn0019686:6 Drosophila melanogaster
intron_FBgn0019686:10_FBgn0019686:11 Drosophila melanogaster
intron_FBgn0019686:7_FBgn0019686:9 Drosophila melanogaster
intron_FBgn0019686:9_FBgn0019686:10 Drosophila melanogaster

28 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage lok none 0.097913521   19067489
Lipid storage lok none 1.681467102   19067489
Cell cycle regulation (1) lok none np   15616552
Cell cycle regulation (2) lok none np   15616552
Cell size and cell-cycle regulation (1) lok none sp   16496002
Cell size and cell-cycle regulation (1) lok none sp   16496002
Combinatorial effect with methyl methanesulphonate (2) lok Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) lok none np   20220848
Heat nociception (1) lok none -0.09   21074052
Heart development and function (1) lok none 1   20371351
Serratia marcescens infection (1) lok none 0.323529411764705   19520911
Notch pathway regulation (4) lok none 0   19363474
Notch induced transcription lok none 0.55835 without Notch stimulation 20959007
Notch induced transcription lok Upregulation of Notch pathway after Notch stimulation 2.1472 N(delta)ecn Notch stimulation 20959007
Notch induced transcription lok none 1.2912 N(delta)ecn Notch stimulation 20959007
Notch pathway regulation (1) lok Upregulation of Notch pathway np   20493818
Notch pathway regulation (2) lok none np en-GAL4 20493818
Notch pathway regulation (2) lok none np en-GAL4 20493818
Notch pathway regulation (3) lok none np   20493818
Adiposity regulation (1) lok none -0.243   20074523
Actin organization and cell morphology (1) lok none np   19265526
Actin organization and cell morphology (2) lok none np   19265526
Actin organization and cell morphology (3) lok none np   19265526
Actin organization and cell morphology (4) lok none np   19265526
Actin organization and cell morphology (5) lok none np   19265526
Actin organization and cell morphology (6) lok none np   19265526
Vaccinia virus infection lok none sp   20585561
Hippo pathway regulation lok none 0.33   23263283

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