Genomics
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9 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0268430 | Rpn9[NIG.10230R] | Drosophila melanogaster | |
| FBal0155937 | Rpn9[EY03352] | Drosophila melanogaster | |
| FBal0257675 | Rpn9[HMS01007] | Drosophila melanogaster | |
| FBal0130779 | Rpn9[EP3439] | Drosophila melanogaster | |
| FBal0100038 | Rpn9[S071806b] | Drosophila melanogaster | |
| FBal0286950 | Rpn9[Scer\UAS.ORF] | Drosophila melanogaster | |
| FBal0286951 | Rpn9[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0208413 | Rpn9[GD6909] | Drosophila melanogaster | |
| FBal0231689 | Rpn9[KK102254] | Drosophila melanogaster |
80 Clones
7 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0028691:7 | Rpn9:7 |
| FBgn0028691:5 | Rpn9:5 |
| FBgn0028691:4 | Rpn9:4 |
| FBgn0028691:3 | Rpn9:3 |
| FBgn0028691:1 | Rpn9:1 |
| FBgn0028691:6 | Rpn9:6 |
| FBgn0028691:2 | Rpn9:2 |
4 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0084469-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0084470-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0084469-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0084470-3-prime-utr | Drosophila melanogaster |
Other
74 Pathways
- Cross-presentation of soluble exogenous antigens (endosomes),
- Mitotic Anaphase,
- SCF(Skp2)-mediated degradation of p27/p21,
- Homologous recombination repair of replication-independent double-strand breaks,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- DNA Replication Pre-Initiation,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- Double-Strand Break Repair,
- Cyclin E associated events during G1/S transition,
- G2/M DNA replication checkpoint,
- Orc1 removal from chromatin,
- DNA Repair,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- Activation of NF-kappaB in B Cells,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- Cell Cycle Checkpoints,
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- Signaling Pathways,
- Class I MHC mediated antigen processing & presentation,
- Cyclin A/B1 associated events during G2/M transition,
- M Phase,
- Mitotic M-M/G1 phases,
- Mitotic G2-G2/M phases,
- Beta-catenin phosphorylation cascade,
- Mitotic Spindle Checkpoint,
- Polo-like kinase mediated events,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- Degradation of beta-catenin by the destruction complex,
- DNA Replication,
- Apoptosis,
- Cell Cycle, Mitotic,
- Amplification of signal from the kinetochores,
- B Cell Activation,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- ER-Phagosome pathway,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- G2/M DNA damage checkpoint,
- Switching of origins to a post-replicative state,
- Downstream Signaling Events Of B Cell Receptor (BCR),
- G2/M Transition,
- G1/S DNA Damage Checkpoints,
- Signaling by Wnt,
- Cell Cycle,
- ATM mediated response to DNA double-strand break,
- Regulation of Apoptosis,
- Mitotic G1-G1/S phases,
- CDK-mediated phosphorylation and removal of Cdc6,
- APC/C:Cdc20 mediated degradation of Securin,
- Regulation of DNA replication,
- Cyclin A:Cdk2-associated events at S phase entry,
- p53-Independent G1/S DNA damage checkpoint,
- SCF-beta-TrCP mediated degradation of Emi1,
- Adaptive Immune System,
- p53-Independent DNA Damage Response,
- Autodegradation of Cdh1 by Cdh1:APC/C,
- Synthesis of DNA,
- Separation of Sister Chromatids,
- Antigen processing-Cross presentation,
- S Phase,
- APC/C-mediated degradation of cell cycle proteins,
- M/G1 Transition,
- G1/S Transition,
- Removal of licensing factors from origins,
- Antigen processing: Ubiquitination & Proteasome degradation,
- Regulation of mitotic cell cycle,
- Mitotic Metaphase and Anaphase,
- Regulation of APC/C activators between G1/S and early anaphase,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- Homologous Recombination Repair,
- Regulation of activated PAK-2p34 by proteasome mediated degradation,
- Immune System,
- G2/M Checkpoints,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 42802 | NCBI Entrez Gene identifiers | FBgn0028691 |
| 67740 | BioGRID | FBgn0028691 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| TrEMBL data set | http://www.ebi.ac.uk/trembl/ |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
6 Introns
24 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | Rpn9 | none | 0.619018744 | 19067489 | |
| Lipid storage | Rpn9 | none | -0.308709077 | 19067489 | |
| ERK signaling | Rpn9 | ERK activation reduced | weak | 17086199 | |
| Cell size and cell-cycle regulation (1) | Rpn9 | Increased G1 DNA content | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | Rpn9 | none | 1.188 | 16496002 | |
| Cell size and cell-cycle regulation (3) | Rpn9 | none | 429 | 16496002 | |
| Mitochondrial biogenesis and function | Rpn9 | Increased mitochondrial citrate synthase activity, decreased viability | 1.987 | 18042644 | |
| Mutant human huntingtin aggregation | Rpn9 | Decreased mutant human huntingtin aggregation | <= -2 | 19789644 | |
| Muscle morphogenesis and function (1) | Rpn9 | Lethal | np | 20220848 | |
| Heat nociception (1) | Rpn9 | Developmentally lethal | 0.62 | 21074052 | |
| Heart development and function (1) | Rpn9 | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | Rpn9 | none | -0.890410958904109 | 19520911 | |
| Notch pathway regulation (4) | Rpn9 | Completely lethal (pupal) | sp | 19363474 | |
| Adiposity regulation (1) | Rpn9 | Decreased triglyceride expression | -0.527 | 20074523 | |
| Adiposity regulation (2) | Rpn9 | Increased triglyceride expression | 0.343 | 20074523 | |
| Adiposity regulation (3) | Rpn9 | none | 0.003 | 20074523 | |
| Adiposity regulation (4) | Rpn9 | none | 0.16 | 20074523 | |
| Adiposity regulation (5) | Rpn9 | Lethal or developmental delay | d/l | 20074523 | |
| RTK-Ras-ERK pathway regulation (1) | Rpn9 | Decreased ERK phosphorylation after EGF stimulation | -2.26 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | Rpn9 | none | -1.03 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Rpn9 | none | 0.74 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Rpn9 | Increased ERK phosphorylation after sSpitz and EGF stimulation | 1.62 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | Rpn9 | none | -2.38 | 23263283 | |
| Glycosylation regulation (1) | Rpn9 | none | sp | 21203496 |
