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Gene : Prosbeta2 D. melanogaster

DB identifier  ? FBgn0023174 Secondary Identifier  ? CG3329
Name  ? Proteasome beta2 subunit Source  FlyBase
  • synonyms:
  • beta2_dm,
  • Prosbeta 2,
  • DTS-7,
  • DTS7,
  • unnamed,
  • anon-fast-evolving-1G6,
  • anon-fast-evolving-1E6,
  • beta2,
  • Prosbeta,
  • FBgn0002419,
  • FBan0003329,
  • 20S proteasome,
  • b2,
  • FBgn0023174,
  • 3329,
  • FBgn0025254,
  • l(3)DTS7,
  • CG3329,
  • b2 subunit,
  • Beta-2,
  • beta2 proteosome subunit,
  • anon-EST:fe1G6,
  • PROSbeta2,
  • FBgn0025245,
  • anon-EST:fe1E6,
  • Proteasome beta2 subunit,
  • beta 2

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18 Alleles

DB identifier Symbol Allele Class Organism
FBal0268428 Prosbeta2[NIG.3329R]   Drosophila melanogaster
FBal0182146 Prosbeta2[f04632]   Drosophila melanogaster
FBal0182145 Prosbeta2[f05195]   Drosophila melanogaster
FBal0182147 Prosbeta2[f03070]   Drosophila melanogaster
FBal0130821 Prosbeta2[EP3067]   Drosophila melanogaster
FBal0286687 Prosbeta2[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286688 Prosbeta2[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0095638 Prosbeta2[+t2.7]   Drosophila melanogaster
FBal0095633 Prosbeta2[rv3D]   Drosophila melanogaster
FBal0095634 Prosbeta2[rv3gamma]   Drosophila melanogaster
FBal0095635 Prosbeta2[rv19X]   Drosophila melanogaster
FBal0010845 Prosbeta2[1]   Drosophila melanogaster
FBal0095636 Prosbeta2[rv12gamma]   Drosophila melanogaster
FBal0095637 Prosbeta2[rv11gamma]   Drosophila melanogaster
FBal0141583 Prosbeta2[1.Scer\UAS]   Drosophila melanogaster
FBal0208129 Prosbeta2[GD10938]   Drosophila melanogaster
FBal0214698 Prosbeta2[GD16438]   Drosophila melanogaster
FBal0231267 Prosbeta2[KK101430]   Drosophila melanogaster

66 Clones

Secondary Identifier DB identifier
AA433215 FBcl0000375
AA433227 FBcl0000417
AT28949 FBcl0018855
AT05178 FBcl0018873
AT24619 FBcl0018891
EK156038 FBcl0051018
EK235457 FBcl0051020
EK202520 FBcl0051132
EK187163 FBcl0051138
EC31686 FBcl0065403
EC26120 FBcl0065423
EC35062 FBcl0065427
EP10927 FBcl0079345
GM06522 FBcl0140341
GM13888 FBcl0145449
HL04316 FBcl0150641
LD44234 FBcl0177603
LD28095 FBcl0177653
LD41671 FBcl0177658
LD40617 FBcl0177660
LP03457 FBcl0190684
LP19877 FBcl0190689
LP04366 FBcl0190690
LP07941 FBcl0190694
LP15866 FBcl0190700
LP14445 FBcl0190701
RE49030 FBcl0235339
RE21784 FBcl0235381
RE44512 FBcl0235387
RE06696 FBcl0235399

3 Exons

DB identifier Symbol
FBgn0023174:1 Prosbeta2:1
FBgn0023174:2 Prosbeta2:2
FBgn0023174:3 Prosbeta2:3

1 Transcripts

DB identifier Gene
FBtr0075629 Prosbeta2

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0075629-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0075629-3-prime-utr Drosophila melanogaster

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74 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
39628 NCBI Entrez Gene identifiers FBgn0023174
64952 BioGRID FBgn0023174

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 3409.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 4023.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 3081.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 3529.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 3680.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 3871.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 2877.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 3117.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1811.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 4196.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 3538.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 4139.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 2714.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 4613.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 5283.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 3411.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 3729.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 3139.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 4492.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 3565.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 3151.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 3880.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 2696.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 2590.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2944.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 7648.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 6453.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 4336.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 3061.0
FBgn0023174 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 3176.0

2 Introns

DB identifier
Organism . Name
intron_FBgn0023174:1_FBgn0023174:2 Drosophila melanogaster
intron_FBgn0023174:2_FBgn0023174:3 Drosophila melanogaster

35 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Prosbeta2 none -3.452281737   19067489
Lipid storage Prosbeta2 none 2.127777269   19067489
Lipid storage Prosbeta2 none -0.477361841   19067489
ERK signaling Prosbeta2 ERK activation reduced weak   17086199
Intracellular Listeria monocytogenes infection Prosbeta2 Decreased GFP protein expression moderate   16020693
L. monocytogenes infection Prosbeta2 Less infected cells or fewer bacteria per cell in LLO- strain ***   16157870
Hedgehog signaling Prosbeta2 Decreased Hedgehog reporter activity -2.52   16311596
Constitutive protein secretion and Golgi organization (1) Prosbeta2 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Prosbeta2 Decreased viability sp   16496002
Cell size and cell-cycle regulation (2) Prosbeta2 none 1.204   16496002
Cell size and cell-cycle regulation (3) Prosbeta2 none 430   16496002
Candida albicans phagocytosis (1) Prosbeta2 none np   16336044
Lipid storage Prosbeta2 Fewer lipid droplets strong   18408709
Combinatorial effect with methyl methanesulphonate (2) Prosbeta2 Synthetic lethal with methyl methanesulphonate sp   19543366
Mutant human huntingtin aggregation Prosbeta2 Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) Prosbeta2 Lethal np   20220848
Muscle morphogenesis and function (2) Prosbeta2 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Heat nociception (1) Prosbeta2 none -1.17   21074052
Heart development and function (1) Prosbeta2 none 1   20371351
Serratia marcescens infection (1) Prosbeta2 none 0.0909090909090909   19520911
Notch pathway regulation (4) Prosbeta2 Completely lethal (before pupal) sp   19363474
PGN-induced dJNK phosphorylation Prosbeta2 Increased P-JNK protein expression with PGN 2.55 15 min PGN induction 19893628
Muscle assembly and maintenance Prosbeta2 Muscles spread, myosin filaments striated, actin filaments lack striation severe   18359903
Hh pathway regulation Prosbeta2 Downregulation of Hh pathway -0.432836269102688   17903264
Hh pathway regulation Prosbeta2 Downregulation of Hh pathway -0.295010413644592   17903264
Adiposity regulation (1) Prosbeta2 none -0.67   20074523
Blood cell homeostasis regulation (1) Prosbeta2 none np   20540764
Blood cell homeostasis regulation (2) Prosbeta2 none np   20540764
RTK-Ras-ERK pathway regulation (1) Prosbeta2 Decreased ERK phosphorylation after EGF stimulation -3.62 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Prosbeta2 none -1.43 0 minutes EGF stimulation 22028469

0 Submissions