Genomics
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18 Alleles
66 Clones
3 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0023174:1 | Prosbeta2:1 |
| FBgn0023174:2 | Prosbeta2:2 |
| FBgn0023174:3 | Prosbeta2:3 |
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0075629-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0075629-3-prime-utr | Drosophila melanogaster |
Other
74 Pathways
- Immune System,
- Regulation of Apoptosis,
- Regulation of mitotic cell cycle,
- Regulation of APC/C activators between G1/S and early anaphase,
- Cell Cycle,
- Apoptosis,
- p53-Independent DNA Damage Response,
- Orc1 removal from chromatin,
- M Phase,
- Cell Cycle Checkpoints,
- DNA Replication Pre-Initiation,
- Amplification of signal from the kinetochores,
- APC/C:Cdc20 mediated degradation of Securin,
- Class I MHC mediated antigen processing & presentation,
- Cyclin A:Cdk2-associated events at S phase entry,
- Autodegradation of Cdh1 by Cdh1:APC/C,
- Regulation of activated PAK-2p34 by proteasome mediated degradation,
- B Cell Activation,
- Antigen processing: Ubiquitination & Proteasome degradation,
- CDK-mediated phosphorylation and removal of Cdc6,
- Mitotic Metaphase and Anaphase,
- Mitotic M-M/G1 phases,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Switching of origins to a post-replicative state,
- Removal of licensing factors from origins,
- Homologous Recombination Repair,
- Homologous recombination repair of replication-independent double-strand breaks,
- Antigen processing-Cross presentation,
- Activation of NF-kappaB in B Cells,
- G2/M DNA replication checkpoint,
- M/G1 Transition,
- Signaling by Wnt,
- Degradation of beta-catenin by the destruction complex,
- Polo-like kinase mediated events,
- G1/S Transition,
- Mitotic G2-G2/M phases,
- Regulation of DNA replication,
- Cyclin A/B1 associated events during G2/M transition,
- G2/M Checkpoints,
- Separation of Sister Chromatids,
- Beta-catenin phosphorylation cascade,
- SCF-beta-TrCP mediated degradation of Emi1,
- Adaptive Immune System,
- Cross-presentation of soluble exogenous antigens (endosomes),
- G2/M Transition,
- Mitotic Anaphase,
- DNA Repair,
- Synthesis of DNA,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- Cyclin E associated events during G1/S transition,
- Cell Cycle, Mitotic,
- Downstream Signaling Events Of B Cell Receptor (BCR),
- G2/M DNA damage checkpoint,
- SCF(Skp2)-mediated degradation of p27/p21,
- Double-Strand Break Repair,
- p53-Independent G1/S DNA damage checkpoint,
- APC/C-mediated degradation of cell cycle proteins,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- Mitotic Spindle Checkpoint,
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- ATM mediated response to DNA double-strand break,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- Mitotic G1-G1/S phases,
- DNA Replication,
- ER-Phagosome pathway,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- Signaling Pathways,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- S Phase,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- G1/S DNA Damage Checkpoints
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 39628 | NCBI Entrez Gene identifiers | FBgn0023174 |
| 64952 | BioGRID | FBgn0023174 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| TrEMBL data set | http://www.ebi.ac.uk/trembl/ |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
2 Introns
| DB identifier |
Organism . Name |
|---|---|
| intron_FBgn0023174:1_FBgn0023174:2 | Drosophila melanogaster |
| intron_FBgn0023174:2_FBgn0023174:3 | Drosophila melanogaster |
35 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | Prosbeta2 | none | -3.452281737 | 19067489 | |
| Lipid storage | Prosbeta2 | none | 2.127777269 | 19067489 | |
| Lipid storage | Prosbeta2 | none | -0.477361841 | 19067489 | |
| ERK signaling | Prosbeta2 | ERK activation reduced | weak | 17086199 | |
| Intracellular Listeria monocytogenes infection | Prosbeta2 | Decreased GFP protein expression | moderate | 16020693 | |
| L. monocytogenes infection | Prosbeta2 | Less infected cells or fewer bacteria per cell in LLO- strain | *** | 16157870 | |
| Hedgehog signaling | Prosbeta2 | Decreased Hedgehog reporter activity | -2.52 | 16311596 | |
| Constitutive protein secretion and Golgi organization (1) | Prosbeta2 | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
| Cell size and cell-cycle regulation (1) | Prosbeta2 | Decreased viability | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | Prosbeta2 | none | 1.204 | 16496002 | |
| Cell size and cell-cycle regulation (3) | Prosbeta2 | none | 430 | 16496002 | |
| Candida albicans phagocytosis (1) | Prosbeta2 | none | np | 16336044 | |
| Lipid storage | Prosbeta2 | Fewer lipid droplets | strong | 18408709 | |
| Combinatorial effect with methyl methanesulphonate (2) | Prosbeta2 | Synthetic lethal with methyl methanesulphonate | sp | 19543366 | |
| Mutant human huntingtin aggregation | Prosbeta2 | Decreased mutant human huntingtin aggregation | <= -2 | 19789644 | |
| Muscle morphogenesis and function (1) | Prosbeta2 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | Prosbeta2 | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Heat nociception (1) | Prosbeta2 | none | -1.17 | 21074052 | |
| Heart development and function (1) | Prosbeta2 | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | Prosbeta2 | none | 0.0909090909090909 | 19520911 | |
| Notch pathway regulation (4) | Prosbeta2 | Completely lethal (before pupal) | sp | 19363474 | |
| PGN-induced dJNK phosphorylation | Prosbeta2 | Increased P-JNK protein expression with PGN | 2.55 | 15 min PGN induction | 19893628 |
| Muscle assembly and maintenance | Prosbeta2 | Muscles spread, myosin filaments striated, actin filaments lack striation | severe | 18359903 | |
| Hh pathway regulation | Prosbeta2 | Downregulation of Hh pathway | -0.432836269102688 | 17903264 | |
| Hh pathway regulation | Prosbeta2 | Downregulation of Hh pathway | -0.295010413644592 | 17903264 | |
| Adiposity regulation (1) | Prosbeta2 | none | -0.67 | 20074523 | |
| Blood cell homeostasis regulation (1) | Prosbeta2 | none | np | 20540764 | |
| Blood cell homeostasis regulation (2) | Prosbeta2 | none | np | 20540764 | |
| RTK-Ras-ERK pathway regulation (1) | Prosbeta2 | Decreased ERK phosphorylation after EGF stimulation | -3.62 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | Prosbeta2 | none | -1.43 | 0 minutes EGF stimulation | 22028469 |
