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Gene : Prosalpha1 D. melanogaster

DB identifier  ? FBgn0263121 Secondary Identifier  ? CG18495
Name  ? Proteasome alpha1 subunit Source  FlyBase
  • synonyms:
  • 18495,
  • CG18495,
  • 20S proteasome,
  • FBgn0065188,
  • FBgn0033228,
  • PSA6_DROME,
  • Prosalpha6,
  • 20S proteasome subunit alpha1,
  • alpha-subunit of 20S proteasome,
  • FBgn0026781,
  • l(2)SH2 2342,
  • alpha1,
  • Proteasome alpha6 subunit,
  • l(2)SH2342,
  • Prosalpha1,
  • FBan0018495,
  • Alpha-1,
  • FBgn0263121,
  • lethal (2) SH2342

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5 Alleles

DB identifier Symbol Allele Class Organism
FBal0268427 Prosalpha1[NIG.18495R]   Drosophila melanogaster
FBal0143425 Prosalpha1[SH2342]   Drosophila melanogaster
FBal0287433 Prosalpha1[Scer\UAS.ORF]   Drosophila melanogaster
FBal0287434 Prosalpha1[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0130822 Prosalpha1[EP2318]   Drosophila melanogaster

46 Clones

Secondary Identifier DB identifier
AT03444 FBcl0030147
AT21976 FBcl0030151
AT22113 FBcl0030155
GH26123 FBcl0112715
EK185510 FBcl0135148
EK223659 FBcl0135150
EK086534 FBcl0135166
EK259057 FBcl0135168
EK114808 FBcl0135170
GM08626 FBcl0142370
LP10435 FBcl0183134
LP10168 FBcl0183142
LP19455 FBcl0183143
LP06364 FBcl0188339
RE59355 FBcl0206391
RE52084 FBcl0206471
RH01991 FBcl0269194
SD23301 FBcl0287018
SD13316 FBcl0287031
UT01861 FBcl0292840
IP18440 FBcl0340701
IP09392 FBcl0340705
LD47174 FBcl0340707
IP18740 FBcl0340708
Dmel_dig_014085_0664_2963 FBcl0376077
Dmel_dig_017193_0707_2846 FBcl0376078
FGA008G06 FBcl0384467
FGC001B12 FBcl0384712
FGC018E11 FBcl0385479
FGM002F02 FBcl0388857

5 Exons

DB identifier Symbol
FBgn0263121:5 Prosalpha1:5
FBgn0263121:3 Prosalpha1:3
FBgn0263121:2 Prosalpha1:2
FBgn0263121:1 Prosalpha1:1
FBgn0263121:4 Prosalpha1:4

2 Transcripts

DB identifier Gene
FBtr0088896 Prosalpha1
FBtr0088895 Prosalpha1

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0088896-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0088895-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0088896-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0088895-3-prime-utr Drosophila melanogaster

Interactions

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Other

74 Pathways

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
45780 NCBI Entrez Gene identifiers FBgn0263121
34359, 45780 NCBI Entrez Gene identifiers FBgn0263121
45780, 246582 NCBI Entrez Gene identifiers FBgn0263121
69878 BioGRID FBgn0263121

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

4 Introns

DB identifier
Organism . Name
intron_FBgn0263121:5_FBgn0263121:3 Drosophila melanogaster
intron_FBgn0263121:3_FBgn0263121:2 Drosophila melanogaster
intron_FBgn0263121:2_FBgn0263121:1 Drosophila melanogaster
intron_FBgn0263121:4_FBgn0263121:3 Drosophila melanogaster

26 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Intracellular Listeria monocytogenes infection Prosalpha1 Decreased GFP protein expression strong   16020693
Cell size and cell-cycle regulation (1) Prosalpha1 none sp   16496002
Candida albicans phagocytosis (1) Prosalpha1 none np   16336044
Combinatorial effect with methyl methanesulphonate (2) Prosalpha1 Synthetic lethal with methyl methanesulphonate sp   19543366
Mutant human huntingtin aggregation Prosalpha1 Decreased mutant human huntingtin aggregation <= -2   19789644
Heat nociception (1) Prosalpha1 none -1.17   21074052
Heat nociception (1) Prosalpha1 none -1.17   21074052
Heat nociception (1) Prosalpha1 Developmentally lethal 0   21074052
Heat nociception (1) Prosalpha1 Developmentally lethal 0   21074052
Serratia marcescens infection (1) Prosalpha1 none -1.3015873015873   19520911
Serratia marcescens infection (1) Prosalpha1 none -0.548148148148148   19520911
Serratia marcescens infection (1) Prosalpha1 none 0.00854700854700854   19520911
Self-renewal and differentiation in neural stem cells Prosalpha1 GFP aggregates number, GFP aggregates size, neuroblast larger cell size, neuroblast cell shape, ganglion mother cell shorter lineages, neuroblast underproliferation, lethal sp   21549331
Blood cell homeostasis regulation (1) Prosalpha1 Increased melanotic mass formation np   20540764
Blood cell homeostasis regulation (2) Prosalpha1 Increased melanotic mass formation np   20540764
Blood cell homeostasis regulation (3) Prosalpha1 Increased melanotic mass formation 26.7   20540764
Blood cell homeostasis regulation (4) Prosalpha1 none 4.8   20540764
Blood cell homeostasis regulation (5) Prosalpha1 Lethal np   20540764
Blood cell homeostasis regulation (6) Prosalpha1 none 1.6   20540764
Blood cell homeostasis regulation (7) Prosalpha1 none 0   20540764
Blood cell homeostasis regulation (8) Prosalpha1 none 0   20540764
RTK-Ras-ERK pathway regulation (1) Prosalpha1 Decreased ERK phosphorylation after EGF stimulation -1.81 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Prosalpha1 none -1.15 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Prosalpha1 none 1.38 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Prosalpha1 Increased ERK phosphorylation after sSpitz and EGF stimulation 1.59 10 minutes sSpitz stimulation 22028469
Glycosylation regulation (1) Prosalpha1 Decreased Chp protein expression np   21203496

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