Genomics
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5 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0268427 | Prosalpha1[NIG.18495R] | Drosophila melanogaster | |
| FBal0143425 | Prosalpha1[SH2342] | Drosophila melanogaster | |
| FBal0287433 | Prosalpha1[Scer\UAS.ORF] | Drosophila melanogaster | |
| FBal0287434 | Prosalpha1[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0130822 | Prosalpha1[EP2318] | Drosophila melanogaster |
46 Clones
5 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0263121:5 | Prosalpha1:5 |
| FBgn0263121:3 | Prosalpha1:3 |
| FBgn0263121:2 | Prosalpha1:2 |
| FBgn0263121:1 | Prosalpha1:1 |
| FBgn0263121:4 | Prosalpha1:4 |
4 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0088896-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0088895-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0088896-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0088895-3-prime-utr | Drosophila melanogaster |
Other
74 Pathways
- Mitotic Metaphase and Anaphase,
- Apoptosis,
- Regulation of activated PAK-2p34 by proteasome mediated degradation,
- Regulation of DNA replication,
- CDK-mediated phosphorylation and removal of Cdc6,
- Amplification of signal from the kinetochores,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- G1/S Transition,
- Antigen processing: Ubiquitination & Proteasome degradation,
- Orc1 removal from chromatin,
- G2/M Checkpoints,
- DNA Replication,
- Downstream Signaling Events Of B Cell Receptor (BCR),
- Synthesis of DNA,
- Regulation of mitotic cell cycle,
- Immune System,
- Polo-like kinase mediated events,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- DNA Replication Pre-Initiation,
- Cell Cycle Checkpoints,
- Mitotic G2-G2/M phases,
- SCF(Skp2)-mediated degradation of p27/p21,
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- SCF-beta-TrCP mediated degradation of Emi1,
- Regulation of Apoptosis,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- Beta-catenin phosphorylation cascade,
- Mitotic Anaphase,
- Switching of origins to a post-replicative state,
- M Phase,
- Cyclin A:Cdk2-associated events at S phase entry,
- APC/C-mediated degradation of cell cycle proteins,
- G2/M Transition,
- Cyclin A/B1 associated events during G2/M transition,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- Cell Cycle, Mitotic,
- Degradation of beta-catenin by the destruction complex,
- p53-Independent DNA Damage Response,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- Class I MHC mediated antigen processing & presentation,
- Antigen processing-Cross presentation,
- B Cell Activation,
- Mitotic M-M/G1 phases,
- Cyclin E associated events during G1/S transition,
- Adaptive Immune System,
- Cross-presentation of soluble exogenous antigens (endosomes),
- M/G1 Transition,
- G2/M DNA replication checkpoint,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- Activation of NF-kappaB in B Cells,
- Mitotic Spindle Checkpoint,
- Signaling by Wnt,
- S Phase,
- ER-Phagosome pathway,
- APC/C:Cdc20 mediated degradation of Securin,
- p53-Independent G1/S DNA damage checkpoint,
- ATM mediated response to DNA double-strand break,
- Removal of licensing factors from origins,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Homologous recombination repair of replication-independent double-strand breaks,
- Mitotic G1-G1/S phases,
- Homologous Recombination Repair,
- Separation of Sister Chromatids,
- G2/M DNA damage checkpoint,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- Signaling Pathways,
- Regulation of APC/C activators between G1/S and early anaphase,
- Autodegradation of Cdh1 by Cdh1:APC/C,
- Cell Cycle,
- Double-Strand Break Repair,
- DNA Repair,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- G1/S DNA Damage Checkpoints
4 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 45780 | NCBI Entrez Gene identifiers | FBgn0263121 |
| 34359, 45780 | NCBI Entrez Gene identifiers | FBgn0263121 |
| 45780, 246582 | NCBI Entrez Gene identifiers | FBgn0263121 |
| 69878 | BioGRID | FBgn0263121 |
10 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster |
26 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Intracellular Listeria monocytogenes infection | Prosalpha1 | Decreased GFP protein expression | strong | 16020693 | |
| Cell size and cell-cycle regulation (1) | Prosalpha1 | none | sp | 16496002 | |
| Candida albicans phagocytosis (1) | Prosalpha1 | none | np | 16336044 | |
| Combinatorial effect with methyl methanesulphonate (2) | Prosalpha1 | Synthetic lethal with methyl methanesulphonate | sp | 19543366 | |
| Mutant human huntingtin aggregation | Prosalpha1 | Decreased mutant human huntingtin aggregation | <= -2 | 19789644 | |
| Heat nociception (1) | Prosalpha1 | none | -1.17 | 21074052 | |
| Heat nociception (1) | Prosalpha1 | none | -1.17 | 21074052 | |
| Heat nociception (1) | Prosalpha1 | Developmentally lethal | 0 | 21074052 | |
| Heat nociception (1) | Prosalpha1 | Developmentally lethal | 0 | 21074052 | |
| Serratia marcescens infection (1) | Prosalpha1 | none | -1.3015873015873 | 19520911 | |
| Serratia marcescens infection (1) | Prosalpha1 | none | -0.548148148148148 | 19520911 | |
| Serratia marcescens infection (1) | Prosalpha1 | none | 0.00854700854700854 | 19520911 | |
| Self-renewal and differentiation in neural stem cells | Prosalpha1 | GFP aggregates number, GFP aggregates size, neuroblast larger cell size, neuroblast cell shape, ganglion mother cell shorter lineages, neuroblast underproliferation, lethal | sp | 21549331 | |
| Blood cell homeostasis regulation (1) | Prosalpha1 | Increased melanotic mass formation | np | 20540764 | |
| Blood cell homeostasis regulation (2) | Prosalpha1 | Increased melanotic mass formation | np | 20540764 | |
| Blood cell homeostasis regulation (3) | Prosalpha1 | Increased melanotic mass formation | 26.7 | 20540764 | |
| Blood cell homeostasis regulation (4) | Prosalpha1 | none | 4.8 | 20540764 | |
| Blood cell homeostasis regulation (5) | Prosalpha1 | Lethal | np | 20540764 | |
| Blood cell homeostasis regulation (6) | Prosalpha1 | none | 1.6 | 20540764 | |
| Blood cell homeostasis regulation (7) | Prosalpha1 | none | 0 | 20540764 | |
| Blood cell homeostasis regulation (8) | Prosalpha1 | none | 0 | 20540764 | |
| RTK-Ras-ERK pathway regulation (1) | Prosalpha1 | Decreased ERK phosphorylation after EGF stimulation | -1.81 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | Prosalpha1 | none | -1.15 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Prosalpha1 | none | 1.38 | 30 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Prosalpha1 | Increased ERK phosphorylation after sSpitz and EGF stimulation | 1.59 | 10 minutes sSpitz stimulation | 22028469 |
| Glycosylation regulation (1) | Prosalpha1 | Decreased Chp protein expression | np | 21203496 |
