Genomics
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32 Alleles
39 Clones
4 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0001291:1 | Jra:1 |
| FBgn0001291:3 | Jra:3 |
| FBgn0001291:4 | Jra:4 |
| FBgn0001291:2 | Jra:2 |
6 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0088410-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0088411-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0330606-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0088410-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0088411-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0330606-3-prime-utr | Drosophila melanogaster |
Other
82 Pathways
- Insulin receptor mediated signaling,
- Interleukin-2 signaling,
- Toll Like Receptor 3 (TLR3) Cascade,
- Toll Like Receptor 2 (TLR2) Cascade,
- Gastrin-CREB signalling pathway via PKC and MAPK,
- Signalling to RAS,
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1,
- Cytokine Signaling in Immune system,
- MyD88:Mal cascade initiated on plasma membrane,
- Oxidative Stress Induced Senescence,
- ARMS-mediated activation,
- Toll Like Receptor 10 (TLR10) Cascade,
- SHC-related events,
- RAF/MAP kinase cascade,
- NGF signalling via TRKA from the plasma membrane,
- Toll Like Receptor 5 (TLR5) Cascade,
- FRS2-mediated cascade,
- MAPK targets/ Nuclear events mediated by MAP kinases,
- GRB2 events in ERBB2 signaling,
- Insulin receptor signalling cascade,
- IRS-related events,
- Disease,
- Signaling by EGFR in Cancer,
- Axon guidance,
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation,
- IRS-related events triggered by IGF1R,
- SHC-related events triggered by IGF1R,
- Signaling by Leptin,
- MAP kinase activation in TLR cascade,
- SHC-mediated signalling,
- Immune System,
- Toll-Like Receptors Cascades,
- Frs2-mediated activation,
- IRAK2 mediated activation of TAK1 complex,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- Signaling by SCF-KIT,
- GRB2 events in EGFR signaling,
- Activated TLR4 signalling,
- MyD88 dependent cascade initiated on endosome,
- Cellular Senescence,
- Insulin signaling pathway,
- SHC1 events in ERBB4 signaling,
- Signaling by NGF,
- Signaling by FGFR,
- Developmental Biology,
- NCAM signaling for neurite out-growth,
- Toll Like Receptor TLR6:TLR2 Cascade,
- Signaling by PDGF,
- Prolonged ERK activation events,
- Toll Like Receptor 7/8 (TLR7/8) Cascade,
- Signaling Pathways,
- Toll Like Receptor TLR1:TLR2 Cascade,
- Downstream signal transduction,
- IGF1R signaling cascade,
- DAP12 interactions,
- TRIF-mediated TLR3/TLR4 signaling,
- Signaling by FGFR in disease,
- Signaling by EGFR,
- Signaling by ERBB4,
- SOS-mediated signalling,
- SHC1 events in ERBB2 signaling,
- MyD88-independent cascade,
- Cellular responses to stress,
- DINR-mediated activation,
- Insulin receptor recycling,
- Signaling by GPCR,
- Fc epsilon receptor (FCERI) signaling,
- DAP12 signaling,
- Signaling by Interleukins,
- Downstream signaling of activated FGFR,
- TRAF6 Mediated Induction of proinflammatory cytokines,
- Signalling to ERKs,
- Toll Like Receptor 4 (TLR4) Cascade,
- Signalling to p38 via RIT and RIN,
- FCERI mediated MAPK activation,
- Innate Immune System,
- Activation of the AP-1 family of transcription factors,
- Toll Like Receptor 9 (TLR9) Cascade,
- IRS-mediated signalling,
- SHC1 events in EGFR signaling,
- MyD88 cascade initiated on plasma membrane,
- Signaling by ERBB2
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 36057 | NCBI Entrez Gene identifiers | FBgn0001291 |
| 61885 | BioGRID | FBgn0001291 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
34 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Cell size regulation | Jra | none | -3.21 | 19216764 | |
| Lipid storage | Jra | none | -2.394016609 | 19067489 | |
| Lipid storage | Jra | none | 0.067497703 | 19067489 | |
| Caspase activation in apoptosis (1) - combinatorial effect with doxorubicin | Jra | Increased viability with doxorubicin | np | 17998402 | |
| Caspase activation in apoptosis (2) - combinatorial effect with doxorubicin | Jra | Decreased caspase-3/7-like activity with doxorubicin | np | 17998402 | |
| ERK signaling | Jra | ERK activation increased | strong | 17086199 | |
| Cell size and cell-cycle regulation (1) | Jra | none | sp | 16496002 | |
| Candida albicans phagocytosis (1) | Jra | Decreased Candida albicans phagocytosis | np | 16336044 | |
| Candida albicans phagocytosis (2) | Jra | Decreased Escherichia coli phagocytosis | 42 | 16336044 | |
| Candida albicans phagocytosis (3) | Jra | Decreased latex beads phagocytosis | 31 | 16336044 | |
| Dendrite pattern formation | Jra | none | np | 16547170 | |
| Heat nociception (1) | Jra | none | -0.4 | 21074052 | |
| Heart development and function (1) | Jra | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | Jra | none | -0.870588235294117 | 19520911 | |
| Notch pathway regulation (4) | Jra | Planar polarity defects, notum malformation migration, overproliferation | sp | 19363474 | |
| Notch pathway regulation (1) | Jra | Upregulation of Notch pathway | np | 20493818 | |
| Notch pathway regulation (2) | Jra | Lethal | strong | en-GAL4 | 20493818 |
| Notch pathway regulation (2) | Jra | Lethal | very strong | en-GAL4 | 20493818 |
| Notch pathway regulation (2) | Jra | none | np | C96-GAL4 | 20493818 |
| Notch pathway regulation (2) | Jra | Downregulation of Notch pathway; adult wing margin: notches | sp | C96-GAL4 | 20493818 |
| Notch pathway regulation (2) | Jra | Downregulation of Notch pathway; wing disc NRE:EGFP: gap | sp | en-GAL4 | 20493818 |
| Notch pathway regulation (2) | Jra | Downregulation of Notch pathway; wing disc NRE:EGFP: up, down, broader, gap; lethal | sp | en-GAL4 | 20493818 |
| Notch pathway regulation (3) | Jra | Only lethal with Notch | np | 20493818 | |
| Adiposity regulation (1) | Jra | none | 0.564 | 20074523 | |
| Blood cell homeostasis regulation (1) | Jra | none | np | 20540764 | |
| Blood cell homeostasis regulation (2) | Jra | none | np | 20540764 | |
| RTK-Ras-ERK pathway regulation (1) | Jra | Increased ERK phosphorylation after EGF stimulation | 2.62 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | Jra | Increased ERK phosphorylation after EGF stimulation | 1.51 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Jra | none | -0.28 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Jra | none | -1.13 | 30 minutes sSpitz stimulation | 22028469 |
