modENCODE |  Help |  blog

Gene : polo D. melanogaster

DB identifier  ? FBgn0003124 Secondary Identifier  ? CG12306
Name  ? polo Source  FlyBase
  • synonyms:
  • POLO,
  • l(3)77Aa,
  • FBgn0010758,
  • l(3)S132408,
  • 1324/08,
  • l(3)01673,
  • FBgn0027987,
  • PLK1,
  • FBgn0046400,
  • FBgn0028177,
  • 0256/04,
  • Polo protein kinase,
  • anon-WO0172774.3,
  • l(3)S025604,
  • FBgn0003124,
  • Polo kinase,
  • FBgn0016019,
  • CG12306,
  • POLO/PLK1,
  • FBan0012306

Sequence Feature Displayer

Publication Counts Displayer

Genomics

Gene Ontology Displayer

Homologue Displayer

Mod Mine G Browse Displayer

Overlapping Features Displayer

Regulatory Regions Displayer

52 Alleles

DB identifier Symbol Allele Class Organism
FBal0243284 polo[tCH322-104P12]   Drosophila melanogaster
FBal0263504 polo[D166N.Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0263503 polo[Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0211802 polo[CC01326]   Drosophila melanogaster
FBal0284272 polo[wt.T:Avic\GFP]   Drosophila melanogaster
FBal0284273 polo[H518A.K520M.T:Avic\GFP]   Drosophila melanogaster
FBal0257219 polo[HMS00530]   Drosophila melanogaster
FBal0178388 polo[d00993]   Drosophila melanogaster
FBal0178387 polo[e01048]   Drosophila melanogaster
FBal0009422 polo[01673]   Drosophila melanogaster
FBal0043645 polo[06089]   Drosophila melanogaster
FBal0046071 polo[16-1]   Drosophila melanogaster
FBal0099891 polo[S132408]   Drosophila melanogaster
FBal0100127 polo[S025604] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0013925 polo[2]   Drosophila melanogaster
FBal0134033 polo[KG03033]   Drosophila melanogaster
FBal0278229 polo[Ubi.T:Avic\GFP]   Drosophila melanogaster
FBal0266498 polo[HMS01591]   Drosophila melanogaster
FBal0264942 polo[J16]   Drosophila melanogaster
FBal0050278 polo[t10]   Drosophila melanogaster
FBal0154737 polo[T18D.GMR] gain of function allele Drosophila melanogaster
FBal0046288 polo[DD2]   Drosophila melanogaster
FBal0102420 polo[C3]   Drosophila melanogaster
FBal0013924 polo[1] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0102418 polo[X8]   Drosophila melanogaster
FBal0046290 polo[DD4]   Drosophila melanogaster
FBal0046289 polo[DD3]   Drosophila melanogaster
FBal0102419 polo[Q1]   Drosophila melanogaster
FBal0046291 polo[DD5]   Drosophila melanogaster
FBal0046292 polo[DD6]   Drosophila melanogaster

213 Clones

Secondary Identifier DB identifier
DPiM_LD11851 FBcl0740706
UUGC1124 FBcl0005935
AT19856 FBcl0016205
bs46b09 FBcl0049145
bs46g04 FBcl0049501
EN04203 FBcl0093703
EK215364 FBcl0138060
EK070944 FBcl0138066
EK230243 FBcl0138068
EK259521 FBcl0138108
EK046956 FBcl0138110
EK061118 FBcl0138114
EK066951 FBcl0138116
EK057461 FBcl0138118
EK216959 FBcl0138120
EK239810 FBcl0138122
EK086946 FBcl0138124
EK067347 FBcl0138126
EK056327 FBcl0138128
EK112527 FBcl0138130
EK037604 FBcl0138132
EK089356 FBcl0138134
EK053648 FBcl0138136
EK188425 FBcl0138138
EK172941 FBcl0138140
EK007728 FBcl0138142
EK303531 FBcl0138144
EK252713 FBcl0138146
GM02827 FBcl0139823
GM03323 FBcl0139825

7 Exons

DB identifier Symbol
FBgn0003124:1 polo:1
FBgn0003124:3 polo:3
FBgn0003124:4 polo:4
FBgn0003124:5 polo:5
FBgn0003124:7 polo:7
FBgn0003124:2 polo:2
FBgn0003124:6 polo:6

2 Transcripts

DB identifier Gene
FBtr0074839 polo
FBtr0100318 polo

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0074839-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0100318-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0074839-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0100318-3-prime-utr Drosophila melanogaster

Interactions

Cytoscape Network Displayer

 

Other

44 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
40232 NCBI Entrez Gene identifiers FBgn0003124
65494 BioGRID FBgn0003124

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 3107.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 2919.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 2030.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 2498.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 2176.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 3091.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 2059.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1469.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1311.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2607.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 2814.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 2087.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1793.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 2696.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 2760.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 2147.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 3178.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2186.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 3037.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 2501.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 2124.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 4727.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 2464.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1848.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2542.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 7452.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 5718.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 5869.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 4604.0
FBgn0003124 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 3255.0

6 Introns

DB identifier
Organism . Name
intron_FBgn0003124:1_FBgn0003124:3 Drosophila melanogaster
intron_FBgn0003124:3_FBgn0003124:4 Drosophila melanogaster
intron_FBgn0003124:4_FBgn0003124:5 Drosophila melanogaster
intron_FBgn0003124:5_FBgn0003124:7 Drosophila melanogaster
intron_FBgn0003124:2_FBgn0003124:3 Drosophila melanogaster
intron_FBgn0003124:5_FBgn0003124:6 Drosophila melanogaster

54 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage polo none 1.417948626   19067489
Lipid storage polo none 0.002526738   19067489
Lipid storage polo none 0.005702442   19067489
Lipid storage polo none 7.018314374   19067489
Lipid storage polo none -0.506671539   19067489
Lipid storage polo none 4.054203116   19067489
Lipid storage polo none -0.64739208   19067489
Caspase activation in apoptosis (1) - combinatorial effect with doxorubicin polo Increased viability with doxorubicin np   17998402
Caspase activation in apoptosis (2) - combinatorial effect with doxorubicin polo none np   17998402
Cell morphology polo Morphology np   14527345
Cell cycle regulation (1) polo Increased G2/M DNA content, increased mitotic index, decreased cytokinetic index, increased number of cells in prometaphase and metaphase, all mitotic defects, spindle defects, no gamma-tubulin at the poles sp   15616552
Cell cycle regulation (2) polo Increased G2/M DNA content np   15616552
Cell size and cell-cycle regulation (1) polo Increased G2 DNA content sp   16496002
Cell size and cell-cycle regulation (1) polo none sp   16496002
Cell size and cell-cycle regulation (1) polo Decreased viability, increased cytokinesis sp   16496002
Cell size and cell-cycle regulation (2) polo none 1.307   16496002
Cell size and cell-cycle regulation (3) polo none 443   16496002
Candida albicans phagocytosis (1) polo Decreased Candida albicans phagocytosis np   16336044
Candida albicans phagocytosis (2) polo Decreased Escherichia coli phagocytosis 36   16336044
Candida albicans phagocytosis (3) polo Decreased latex beads phagocytosis 40   16336044
Mitosis polo Dim gamma-tubulin (centrosome) np   17412918
Centriole duplication and centrosome maturation polo Pericentriolar material (PCM) maturation defect np   18798690
DFoxO signaling polo Decreased dFoxO reporter activity 0.01   18815370
Microtubule assembly and organization polo Decreased centrosome number, monopolar spindle, chromosome alignment defect, unevenly distributed DNA np   18463163
Combinatorial effect with methyl methanesulphonate (2) polo Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) polo Lethal np   20220848
Heat nociception (1) polo Developmentally lethal -1.17   21074052
Heart development and function (1) polo none 0.75   20371351
Heart development and function (2) polo Decreased viability 4.48   20371351
Notch pathway regulation (4) polo Notum malformation death 7   19363474

0 Submissions