Genomics
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52 Alleles
213 Clones
7 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0003124:1 | polo:1 |
| FBgn0003124:3 | polo:3 |
| FBgn0003124:4 | polo:4 |
| FBgn0003124:5 | polo:5 |
| FBgn0003124:7 | polo:7 |
| FBgn0003124:2 | polo:2 |
| FBgn0003124:6 | polo:6 |
4 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0074839-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0100318-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0074839-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0100318-3-prime-utr | Drosophila melanogaster |
Other
44 Pathways
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- Mitotic G1-G1/S phases,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- Resolution of Sister Chromatid Cohesion,
- Cyclin A/B1 associated events during G2/M transition,
- Polo-like kinase mediated events,
- Phosphorylation of the APC/C,
- DNA Replication,
- Mitotic Anaphase,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- Mitotic Metaphase and Anaphase,
- G2/M DNA replication checkpoint,
- cell division,
- Separation of Sister Chromatids,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- p53-Independent G1/S DNA damage checkpoint,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- APC/C:Cdc20 mediated degradation of Securin,
- G2/M Checkpoints,
- Cell Cycle Checkpoints,
- Mitotic G2-G2/M phases,
- APC/C-mediated degradation of cell cycle proteins,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- Golgi Cisternae Pericentriolar Stack Reorganization,
- Homologous Recombination Repair,
- Regulation of PLK1 Activity at G2/M Transition,
- ATM mediated response to DNA double-strand break,
- DNA Repair,
- Cell Cycle, Mitotic,
- M Phase,
- Double-Strand Break Repair,
- Activation of NIMA Kinases NEK9, NEK6, NEK7,
- Nuclear Envelope Breakdown,
- Mitotic Prometaphase,
- G2/M Transition,
- Cell Cycle,
- Mitotic M-M/G1 phases,
- Mitotic Prophase,
- G1/S DNA Damage Checkpoints,
- Homologous recombination repair of replication-independent double-strand breaks,
- G2/M DNA damage checkpoint,
- Regulation of mitotic cell cycle,
- p53-Independent DNA Damage Response
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 40232 | NCBI Entrez Gene identifiers | FBgn0003124 |
| 65494 | BioGRID | FBgn0003124 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
6 Introns
54 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | polo | none | 1.417948626 | 19067489 | |
| Lipid storage | polo | none | 0.002526738 | 19067489 | |
| Lipid storage | polo | none | 0.005702442 | 19067489 | |
| Lipid storage | polo | none | 7.018314374 | 19067489 | |
| Lipid storage | polo | none | -0.506671539 | 19067489 | |
| Lipid storage | polo | none | 4.054203116 | 19067489 | |
| Lipid storage | polo | none | -0.64739208 | 19067489 | |
| Caspase activation in apoptosis (1) - combinatorial effect with doxorubicin | polo | Increased viability with doxorubicin | np | 17998402 | |
| Caspase activation in apoptosis (2) - combinatorial effect with doxorubicin | polo | none | np | 17998402 | |
| Cell morphology | polo | Morphology | np | 14527345 | |
| Cell cycle regulation (1) | polo | Increased G2/M DNA content, increased mitotic index, decreased cytokinetic index, increased number of cells in prometaphase and metaphase, all mitotic defects, spindle defects, no gamma-tubulin at the poles | sp | 15616552 | |
| Cell cycle regulation (2) | polo | Increased G2/M DNA content | np | 15616552 | |
| Cell size and cell-cycle regulation (1) | polo | Increased G2 DNA content | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | polo | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | polo | Decreased viability, increased cytokinesis | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | polo | none | 1.307 | 16496002 | |
| Cell size and cell-cycle regulation (3) | polo | none | 443 | 16496002 | |
| Candida albicans phagocytosis (1) | polo | Decreased Candida albicans phagocytosis | np | 16336044 | |
| Candida albicans phagocytosis (2) | polo | Decreased Escherichia coli phagocytosis | 36 | 16336044 | |
| Candida albicans phagocytosis (3) | polo | Decreased latex beads phagocytosis | 40 | 16336044 | |
| Mitosis | polo | Dim gamma-tubulin (centrosome) | np | 17412918 | |
| Centriole duplication and centrosome maturation | polo | Pericentriolar material (PCM) maturation defect | np | 18798690 | |
| DFoxO signaling | polo | Decreased dFoxO reporter activity | 0.01 | 18815370 | |
| Microtubule assembly and organization | polo | Decreased centrosome number, monopolar spindle, chromosome alignment defect, unevenly distributed DNA | np | 18463163 | |
| Combinatorial effect with methyl methanesulphonate (2) | polo | Synthetic lethal with methyl methanesulphonate | sp | 19543366 | |
| Muscle morphogenesis and function (1) | polo | Lethal | np | 20220848 | |
| Heat nociception (1) | polo | Developmentally lethal | -1.17 | 21074052 | |
| Heart development and function (1) | polo | none | 0.75 | 20371351 | |
| Heart development and function (2) | polo | Decreased viability | 4.48 | 20371351 | |
| Notch pathway regulation (4) | polo | Notum malformation death | 7 | 19363474 |
