Genomics
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9 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0241450 | shtd[2] | Drosophila melanogaster | |
| FBal0241451 | shtd[3.gamma] | Drosophila melanogaster | |
| FBal0241453 | shtd[rescue.Scer\UAS] | Drosophila melanogaster | |
| FBal0258831 | shtd[KK100819] | Drosophila melanogaster | |
| FBal0140936 | shtd[1] | Drosophila melanogaster | |
| FBal0278862 | shtd[HMS01744] | Drosophila melanogaster | |
| FBal0287528 | shtd[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0210576 | shtd[GD14150] | Drosophila melanogaster | |
| FBal0198126 | shtd[3] | loss of function allele | Drosophila melanogaster |
11 Clones
| Secondary Identifier | DB identifier |
|---|---|
| DPiM_LD37115 | FBcl0740633 |
| DMG1-chrX.16.031.a | FBcl0361173 |
| EK286045 | FBcl0129248 |
| GM22507 | FBcl0144627 |
| GM29903 | FBcl0144629 |
| LD37115 | FBcl0171688 |
| RP004207999 | FBcl0503575 |
| CK01.14D.F7 | FBcl0435803 |
| 180906 | FBcl0435830 |
| 214565.29 | FBcl0435842 |
| 62021 | FBcl0435848 |
8 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0004391:8 | shtd:8 |
| FBgn0004391:7 | shtd:7 |
| FBgn0004391:6 | shtd:6 |
| FBgn0004391:5 | shtd:5 |
| FBgn0004391:4 | shtd:4 |
| FBgn0004391:3 | shtd:3 |
| FBgn0004391:2 | shtd:2 |
| FBgn0004391:1 | shtd:1 |
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0074077-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0074077-3-prime-utr | Drosophila melanogaster |
Other
53 Pathways
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- Regulation of APC/C activators between G1/S and early anaphase,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- G2/M DNA replication checkpoint,
- G2/M DNA damage checkpoint,
- Cell Cycle,
- Separation of Sister Chromatids,
- Cellular responses to stress,
- S Phase,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- G2/M Checkpoints,
- p53-Independent G1/S DNA damage checkpoint,
- Mitotic Spindle Checkpoint,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- Mitotic Metaphase and Anaphase,
- Mitotic G2-G2/M phases,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- Polo-like kinase mediated events,
- Phosphorylation of the APC/C,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- SCF(Skp2)-mediated degradation of p27/p21,
- G1/S Transition,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Cyclin A:Cdk2-associated events at S phase entry,
- M Phase,
- G1/S DNA Damage Checkpoints,
- Mitotic G1-G1/S phases,
- Double-Strand Break Repair,
- Cyclin A/B1 associated events during G2/M transition,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- Cell Cycle, Mitotic,
- ATM mediated response to DNA double-strand break,
- Autodegradation of Cdh1 by Cdh1:APC/C,
- Homologous recombination repair of replication-independent double-strand breaks,
- Mitotic M-M/G1 phases,
- DNA Replication,
- Cellular Senescence,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- Cell Cycle Checkpoints,
- APC/C:Cdc20 mediated degradation of Securin,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- G2/M Transition,
- Regulation of mitotic cell cycle,
- APC/C-mediated degradation of cell cycle proteins,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- Mitotic Anaphase,
- DNA Repair,
- Senescence-Associated Secretory Phenotype (SASP),
- Amplification of signal from the kinetochores,
- Homologous Recombination Repair,
- p53-Independent DNA Damage Response,
- Cyclin E associated events during G1/S transition,
- APC-Cdc20 mediated degradation of Nek2A
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 32473 | NCBI Entrez Gene identifiers | FBgn0004391 |
| 58826 | BioGRID | FBgn0004391 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| TrEMBL data set | http://www.ebi.ac.uk/trembl/ |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
7 Introns
19 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | shtd | none | 1.266656941 | 19067489 | |
| Lipid storage | shtd | none | -1.160707621 | 19067489 | |
| Lipid storage | shtd | none | -0.731476068 | 19067489 | |
| Lipid storage | shtd | none | 1.66557879 | 19067489 | |
| Cell size and cell-cycle regulation (1) | shtd | none | sp | 16496002 | |
| Microtubule assembly and organization | shtd | Abnormal spindle | np | 18463163 | |
| Mutant human huntingtin aggregation | shtd | Increased mutant human huntingtin aggregation | >= 2 | 19789644 | |
| Muscle morphogenesis and function (1) | shtd | none | np | 20220848 | |
| Heat nociception (1) | shtd | Developmentally lethal | 0 | 21074052 | |
| Heart development and function (1) | shtd | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | shtd | none | 0.119047619047619 | 19520911 | |
| Notch pathway regulation (4) | shtd | Bristle morphology defects, notum malformation death | sp | 19363474 | |
| Self-renewal and differentiation in neural stem cells | shtd | GFP aggregates number, GFP aggregates size, neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underprolifer | sp | 21549331 | |
| Adiposity regulation (1) | shtd | Decreased triglyceride expression | -0.444 | 20074523 | |
| Adiposity regulation (2) | shtd | none | 0.118 | 20074523 | |
| Adiposity regulation (3) | shtd | none | -0.094 | 20074523 | |
| Adiposity regulation (4) | shtd | Decreased triglyceride expression | -0.986 | 20074523 | |
| Adiposity regulation (5) | shtd | none | -0.073 | 20074523 | |
| Hippo pathway regulation | shtd | none | -2.52 | 23263283 |
