Genomics
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9 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0241450 | shtd[2] | Drosophila melanogaster | |
| FBal0241451 | shtd[3.gamma] | Drosophila melanogaster | |
| FBal0241453 | shtd[rescue.Scer\UAS] | Drosophila melanogaster | |
| FBal0258831 | shtd[KK100819] | Drosophila melanogaster | |
| FBal0140936 | shtd[1] | Drosophila melanogaster | |
| FBal0278862 | shtd[HMS01744] | Drosophila melanogaster | |
| FBal0287528 | shtd[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0210576 | shtd[GD14150] | Drosophila melanogaster | |
| FBal0198126 | shtd[3] | loss of function allele | Drosophila melanogaster |
11 Clones
| Secondary Identifier | DB identifier |
|---|---|
| DPiM_LD37115 | FBcl0740633 |
| DMG1-chrX.16.031.a | FBcl0361173 |
| EK286045 | FBcl0129248 |
| GM22507 | FBcl0144627 |
| GM29903 | FBcl0144629 |
| LD37115 | FBcl0171688 |
| RP004207999 | FBcl0503575 |
| CK01.14D.F7 | FBcl0435803 |
| 180906 | FBcl0435830 |
| 214565.29 | FBcl0435842 |
| 62021 | FBcl0435848 |
8 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0004391:8 | shtd:8 |
| FBgn0004391:7 | shtd:7 |
| FBgn0004391:6 | shtd:6 |
| FBgn0004391:5 | shtd:5 |
| FBgn0004391:4 | shtd:4 |
| FBgn0004391:3 | shtd:3 |
| FBgn0004391:2 | shtd:2 |
| FBgn0004391:1 | shtd:1 |
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0074077-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0074077-3-prime-utr | Drosophila melanogaster |
Other
53 Pathways
- Cell Cycle, Mitotic,
- Mitotic G1-G1/S phases,
- Double-Strand Break Repair,
- Mitotic Anaphase,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- DNA Repair,
- Cellular responses to stress,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- Autodegradation of Cdh1 by Cdh1:APC/C,
- APC/C:Cdc20 mediated degradation of Securin,
- Mitotic M-M/G1 phases,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- APC/C-mediated degradation of cell cycle proteins,
- Regulation of APC/C activators between G1/S and early anaphase,
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Homologous recombination repair of replication-independent double-strand breaks,
- G2/M DNA damage checkpoint,
- Mitotic Metaphase and Anaphase,
- Cell Cycle,
- Mitotic Spindle Checkpoint,
- G1/S DNA Damage Checkpoints,
- Cellular Senescence,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- S Phase,
- Separation of Sister Chromatids,
- SCF(Skp2)-mediated degradation of p27/p21,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- Cyclin A/B1 associated events during G2/M transition,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- p53-Independent DNA Damage Response,
- DNA Replication,
- G2/M Checkpoints,
- Polo-like kinase mediated events,
- Homologous Recombination Repair,
- Mitotic G2-G2/M phases,
- APC-Cdc20 mediated degradation of Nek2A,
- G1/S Transition,
- Cell Cycle Checkpoints,
- Cyclin E associated events during G1/S transition,
- Phosphorylation of the APC/C,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- M Phase,
- G2/M DNA replication checkpoint,
- Regulation of mitotic cell cycle,
- Cyclin A:Cdk2-associated events at S phase entry,
- ATM mediated response to DNA double-strand break,
- Amplification of signal from the kinetochores,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- p53-Independent G1/S DNA damage checkpoint,
- Senescence-Associated Secretory Phenotype (SASP),
- G2/M Transition
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 32473 | NCBI Entrez Gene identifiers | FBgn0004391 |
| 58826 | BioGRID | FBgn0004391 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| TrEMBL data set | http://www.ebi.ac.uk/trembl/ |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
7 Introns
19 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | shtd | none | 1.266656941 | 19067489 | |
| Lipid storage | shtd | none | -1.160707621 | 19067489 | |
| Lipid storage | shtd | none | -0.731476068 | 19067489 | |
| Lipid storage | shtd | none | 1.66557879 | 19067489 | |
| Cell size and cell-cycle regulation (1) | shtd | none | sp | 16496002 | |
| Microtubule assembly and organization | shtd | Abnormal spindle | np | 18463163 | |
| Mutant human huntingtin aggregation | shtd | Increased mutant human huntingtin aggregation | >= 2 | 19789644 | |
| Muscle morphogenesis and function (1) | shtd | none | np | 20220848 | |
| Heat nociception (1) | shtd | Developmentally lethal | 0 | 21074052 | |
| Heart development and function (1) | shtd | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | shtd | none | 0.119047619047619 | 19520911 | |
| Notch pathway regulation (4) | shtd | Bristle morphology defects, notum malformation death | sp | 19363474 | |
| Self-renewal and differentiation in neural stem cells | shtd | GFP aggregates number, GFP aggregates size, neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underprolifer | sp | 21549331 | |
| Adiposity regulation (1) | shtd | Decreased triglyceride expression | -0.444 | 20074523 | |
| Adiposity regulation (2) | shtd | none | 0.118 | 20074523 | |
| Adiposity regulation (3) | shtd | none | -0.094 | 20074523 | |
| Adiposity regulation (4) | shtd | Decreased triglyceride expression | -0.986 | 20074523 | |
| Adiposity regulation (5) | shtd | none | -0.073 | 20074523 | |
| Hippo pathway regulation | shtd | none | -2.52 | 23263283 |
