Genomics
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9 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0241450 | shtd[2] | Drosophila melanogaster | |
| FBal0241451 | shtd[3.gamma] | Drosophila melanogaster | |
| FBal0241453 | shtd[rescue.Scer\UAS] | Drosophila melanogaster | |
| FBal0258831 | shtd[KK100819] | Drosophila melanogaster | |
| FBal0140936 | shtd[1] | Drosophila melanogaster | |
| FBal0278862 | shtd[HMS01744] | Drosophila melanogaster | |
| FBal0287528 | shtd[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0210576 | shtd[GD14150] | Drosophila melanogaster | |
| FBal0198126 | shtd[3] | loss of function allele | Drosophila melanogaster |
11 Clones
| Secondary Identifier | DB identifier |
|---|---|
| DPiM_LD37115 | FBcl0740633 |
| DMG1-chrX.16.031.a | FBcl0361173 |
| EK286045 | FBcl0129248 |
| GM22507 | FBcl0144627 |
| GM29903 | FBcl0144629 |
| LD37115 | FBcl0171688 |
| RP004207999 | FBcl0503575 |
| CK01.14D.F7 | FBcl0435803 |
| 180906 | FBcl0435830 |
| 214565.29 | FBcl0435842 |
| 62021 | FBcl0435848 |
8 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0004391:8 | shtd:8 |
| FBgn0004391:7 | shtd:7 |
| FBgn0004391:6 | shtd:6 |
| FBgn0004391:5 | shtd:5 |
| FBgn0004391:4 | shtd:4 |
| FBgn0004391:3 | shtd:3 |
| FBgn0004391:2 | shtd:2 |
| FBgn0004391:1 | shtd:1 |
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0074077-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0074077-3-prime-utr | Drosophila melanogaster |
Other
53 Pathways
- Cyclin A/B1 associated events during G2/M transition,
- Cellular Senescence,
- G2/M Transition,
- Cellular responses to stress,
- Homologous recombination repair of replication-independent double-strand breaks,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- Cell Cycle Checkpoints,
- Mitotic Spindle Checkpoint,
- Cyclin E associated events during G1/S transition,
- G2/M DNA replication checkpoint,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- DNA Repair,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- Mitotic G2-G2/M phases,
- Regulation of mitotic cell cycle,
- ATM mediated response to DNA double-strand break,
- M Phase,
- S Phase,
- Mitotic G1-G1/S phases,
- Separation of Sister Chromatids,
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- Phosphorylation of the APC/C,
- G2/M Checkpoints,
- APC/C:Cdc20 mediated degradation of Securin,
- DNA Replication,
- G1/S DNA Damage Checkpoints,
- Cyclin A:Cdk2-associated events at S phase entry,
- Polo-like kinase mediated events,
- Cell Cycle,
- Senescence-Associated Secretory Phenotype (SASP),
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- Double-Strand Break Repair,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- Mitotic Metaphase and Anaphase,
- Mitotic M-M/G1 phases,
- p53-Independent DNA Damage Response,
- G2/M DNA damage checkpoint,
- Mitotic Anaphase,
- Regulation of APC/C activators between G1/S and early anaphase,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Autodegradation of Cdh1 by Cdh1:APC/C,
- Cell Cycle, Mitotic,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- G1/S Transition,
- p53-Independent G1/S DNA damage checkpoint,
- APC-Cdc20 mediated degradation of Nek2A,
- SCF(Skp2)-mediated degradation of p27/p21,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- Amplification of signal from the kinetochores,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- APC/C-mediated degradation of cell cycle proteins,
- Homologous Recombination Repair
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 32473 | NCBI Entrez Gene identifiers | FBgn0004391 |
| 58826 | BioGRID | FBgn0004391 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| TrEMBL data set | http://www.ebi.ac.uk/trembl/ |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
7 Introns
19 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | shtd | none | 1.266656941 | 19067489 | |
| Lipid storage | shtd | none | -1.160707621 | 19067489 | |
| Lipid storage | shtd | none | -0.731476068 | 19067489 | |
| Lipid storage | shtd | none | 1.66557879 | 19067489 | |
| Cell size and cell-cycle regulation (1) | shtd | none | sp | 16496002 | |
| Microtubule assembly and organization | shtd | Abnormal spindle | np | 18463163 | |
| Mutant human huntingtin aggregation | shtd | Increased mutant human huntingtin aggregation | >= 2 | 19789644 | |
| Muscle morphogenesis and function (1) | shtd | none | np | 20220848 | |
| Heat nociception (1) | shtd | Developmentally lethal | 0 | 21074052 | |
| Heart development and function (1) | shtd | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | shtd | none | 0.119047619047619 | 19520911 | |
| Notch pathway regulation (4) | shtd | Bristle morphology defects, notum malformation death | sp | 19363474 | |
| Self-renewal and differentiation in neural stem cells | shtd | GFP aggregates number, GFP aggregates size, neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underprolifer | sp | 21549331 | |
| Adiposity regulation (1) | shtd | Decreased triglyceride expression | -0.444 | 20074523 | |
| Adiposity regulation (2) | shtd | none | 0.118 | 20074523 | |
| Adiposity regulation (3) | shtd | none | -0.094 | 20074523 | |
| Adiposity regulation (4) | shtd | Decreased triglyceride expression | -0.986 | 20074523 | |
| Adiposity regulation (5) | shtd | none | -0.073 | 20074523 | |
| Hippo pathway regulation | shtd | none | -2.52 | 23263283 |
