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Gene : Pdk1 D. melanogaster

DB identifier  ? FBgn0020386 Secondary Identifier  ? CG1210
Name  ? Phosphoinositide-dependent kinase 1 Source  FlyBase
  • synonyms:
  • dPDK1,
  • Pk61C|PDK1,
  • PDK1/Pk61C,
  • serine/threonine protein kinase,
  • Pk61C/PDK1,
  • PDK,
  • dPDK-1,
  • CG1201,
  • 1210,
  • Protein kinase 61C,
  • PDK1,
  • CG1210,
  • Phosphoinositide dependent kinase 1,
  • phosphoinositide-dependent kinase 1,
  • PK61C,
  • FBgn0020386,
  • DSTPK61,
  • FBan0001210,
  • PDK-1,
  • FBgn0035098

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74 Alleles

DB identifier Symbol Allele Class Organism
FBal0265719 Pdk1[33]   Drosophila melanogaster
FBal0265720 Pdk1[Scer\UAS.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0265721 Pdk1[Scer\UAS.T:Avic\GFP-YFP.Venus]   Drosophila melanogaster
FBal0282857 Pdk1[Or]   Drosophila melanogaster
FBal0268829 Pdk1[S462]   Drosophila melanogaster
FBal0260528 Pdk1[MI03135]   Drosophila melanogaster
FBal0259665 Pdk1[KK108363]   Drosophila melanogaster
FBal0279741 Pdk1[MI06823]   Drosophila melanogaster
FBal0262245 Pdk1[CPTI001036]   Drosophila melanogaster
FBal0262954 Pdk1[GL00489]   Drosophila melanogaster
FBal0263263 Pdk1[HMS01250]   Drosophila melanogaster
FBal0287540 Pdk1[Scer\UAS.ORF]   Drosophila melanogaster
FBal0287541 Pdk1[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0152312 Pdk1[BG00601]   Drosophila melanogaster
FBal0130825 Pdk1[BG02759]   Drosophila melanogaster
FBal0123127 Pdk1[EP3553]   Drosophila melanogaster
FBal0228485 Pdk1[NP0822]   Drosophila melanogaster
FBal0135870 Pdk1[EP3644]   Drosophila melanogaster
FBal0194930 Pdk1[GS6027]   Drosophila melanogaster
FBal0228492 Pdk1[NP6559]   Drosophila melanogaster
FBal0135872 Pdk1[5] loss of function allele Drosophila melanogaster
FBal0182264 Pdk1[d09019]   Drosophila melanogaster
FBal0228488 Pdk1[NP1340]   Drosophila melanogaster
FBal0135868 Pdk1[unspecified]   Drosophila melanogaster
FBal0241816 Pdk1[EP837rv4]   Drosophila melanogaster
FBal0241817 Pdk1[EP837rv9]   Drosophila melanogaster
FBal0135875 Pdk1[4DeltaEP]   Drosophila melanogaster
FBal0208079 Pdk1[GD7480]   Drosophila melanogaster
FBal0228495 Pdk1[5-HA-1897]   Drosophila melanogaster
FBal0242387 Pdk1[JF02807]   Drosophila melanogaster

163 Clones

Secondary Identifier DB identifier
FGA002G03 FBcl0384257
AT20671 FBcl0025499
AT25285 FBcl0025501
AT28003 FBcl0025505
AT02760 FBcl0025519
AT07663 FBcl0025523
AT09617 FBcl0025529
AT24529 FBcl0025533
EK251355 FBcl0044720
EK141549 FBcl0045104
EK184355 FBcl0045118
EK186420 FBcl0045300
EK241144 FBcl0045402
EK116648 FBcl0045448
EK019460 FBcl0045462
EK008245 FBcl0045476
EK142920 FBcl0045500
EK069901 FBcl0045514
EK239722 FBcl0045526
EK239750 FBcl0045536
EK164857 FBcl0045546
EK248404 FBcl0045558
EK093221 FBcl0045570
EK050405 FBcl0045580
EK073715 FBcl0045590
EK204908 FBcl0045600
EK273207 FBcl0045612
EK208735 FBcl0045620
EK245808 FBcl0045632
EK237548 FBcl0045642

20 Exons

DB identifier Symbol
FBgn0020386:5 Pdk1:5
FBgn0020386:7 Pdk1:7
FBgn0020386:8 Pdk1:8
FBgn0020386:14 Pdk1:14
FBgn0020386:15 Pdk1:15
FBgn0020386:16 Pdk1:16
FBgn0020386:9 Pdk1:9
FBgn0020386:13 Pdk1:13
FBgn0020386:10 Pdk1:10
FBgn0020386:11 Pdk1:11
FBgn0020386:19 Pdk1:19
FBgn0020386:12 Pdk1:12
FBgn0020386:1 Pdk1:1
FBgn0020386:18 Pdk1:18
FBgn0020386:4 Pdk1:4
FBgn0020386:2 Pdk1:2
FBgn0020386:6 Pdk1:6
FBgn0020386:3 Pdk1:3
FBgn0020386:17 Pdk1:17
FBgn0020386:20 Pdk1:20

10 Transcripts

DB identifier Gene
FBtr0072468 Pdk1
FBtr0072467 Pdk1
FBtr0333218 Pdk1
FBtr0072466 Pdk1
FBtr0072464 Pdk1
FBtr0072465 Pdk1
FBtr0302599 Pdk1
FBtr0072470 Pdk1
FBtr0072469 Pdk1
FBtr0072471 Pdk1

18 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0072468-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0072469-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0072470-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0072471-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0072464-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0072465-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0072466-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0072467-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0333218-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072468-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072469-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072470-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072471-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072464-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072465-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072466-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072467-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0333218-3-prime-utr Drosophila melanogaster

Interactions

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Other

74 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
38017 NCBI Entrez Gene identifiers FBgn0020386
63582 BioGRID FBgn0020386

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1016.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 633.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 810.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 3988.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 2991.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1989.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1735.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 3662.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1763.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 3248.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 2825.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1844.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1059.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 460.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 995.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1116.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 460.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1514.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 490.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 839.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1402.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 824.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 549.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 974.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1117.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 4119.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2452.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1784.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1470.0
FBgn0020386 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 2433.0

20 Introns

DB identifier
Organism . Name
intron_FBgn0020386:12_FBgn0020386:14 Drosophila melanogaster
intron_FBgn0020386:14_FBgn0020386:15 Drosophila melanogaster
intron_FBgn0020386:15_FBgn0020386:19 Drosophila melanogaster
intron_FBgn0020386:9_FBgn0020386:13 Drosophila melanogaster
intron_FBgn0020386:13_FBgn0020386:14 Drosophila melanogaster
intron_FBgn0020386:15_FBgn0020386:16 Drosophila melanogaster
intron_FBgn0020386:10_FBgn0020386:11 Drosophila melanogaster
intron_FBgn0020386:11_FBgn0020386:13 Drosophila melanogaster
intron_FBgn0020386:5_FBgn0020386:7 Drosophila melanogaster
intron_FBgn0020386:7_FBgn0020386:8 Drosophila melanogaster
intron_FBgn0020386:8_FBgn0020386:14 Drosophila melanogaster
intron_FBgn0020386:1_FBgn0020386:14 Drosophila melanogaster
intron_FBgn0020386:15_FBgn0020386:17 Drosophila melanogaster
intron_FBgn0020386:1_FBgn0020386:7 Drosophila melanogaster
intron_FBgn0020386:15_FBgn0020386:18 Drosophila melanogaster
intron_FBgn0020386:4_FBgn0020386:7 Drosophila melanogaster
intron_FBgn0020386:3_FBgn0020386:7 Drosophila melanogaster
intron_FBgn0020386:15_FBgn0020386:20 Drosophila melanogaster
intron_FBgn0020386:2_FBgn0020386:6 Drosophila melanogaster
intron_FBgn0020386:6_FBgn0020386:7 Drosophila melanogaster

45 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation Pdk1 none -1.13   19216764
Lipid storage Pdk1 Increased lipid droplet area 2.372550174   19067489
Lipid storage Pdk1 Increased lipid droplet area 6.439134592   19067489
ERK signaling Pdk1 ERK activation increased strong   17086199
Cell cycle regulation (1) Pdk1 Increased G1 DNA content, decreased cell size, decreased mitotic index sp   15616552
Cell cycle regulation (2) Pdk1 Increased G1 DNA content, decreased cell size np   15616552
Cell size and cell-cycle regulation (1) Pdk1 Increased G1 DNA content sp   16496002
Cell size and cell-cycle regulation (1) Pdk1 none sp   16496002
Cell size and cell-cycle regulation (1) Pdk1 none sp   16496002
Cell size and cell-cycle regulation (1) Pdk1 none sp   16496002
Cell size and cell-cycle regulation (1) Pdk1 none sp   16496002
Cell size and cell-cycle regulation (1) Pdk1 none sp   16496002
Cell size and cell-cycle regulation (1) Pdk1 none sp   16496002
Cell size and cell-cycle regulation (1) Pdk1 none sp   16496002
Cell size and cell-cycle regulation (2) Pdk1 none 1.321   16496002
Cell size and cell-cycle regulation (3) Pdk1 none 452   16496002
DFoxO signaling Pdk1 Decreased dFoxO reporter activity 0.001   18815370
Lipid storage Pdk1 Altered mean signal automated analysis   18408709
Combinatorial effect with methyl methanesulphonate (2) Pdk1 Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) Pdk1 none np   20220848
Heat nociception (1) Pdk1 none -0.14   21074052
Heart development and function (1) Pdk1 none 1   20371351
Heart development and function (2) Pdk1 Decreased viability 5.45   20371351
Serratia marcescens infection (1) Pdk1 none 0.929577464788732   19520911
Notch pathway regulation (4) Pdk1 Notum malformation migration 0.6   19363474
Akt-TOR pathway negative feedback regulation Pdk1 Increased dAkt phosphorylation 4.8 without insulin stimulation 20585550
Akt-TOR pathway negative feedback regulation Pdk1 none 2.5 10 min insulin stimulation 20585550
Adiposity regulation (1) Pdk1 none -0.327   20074523
Actin organization and cell morphology (1) Pdk1 none np   19265526
Actin organization and cell morphology (2) Pdk1 none np   19265526

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