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Gene : Sec61alpha D. melanogaster
DB identifier  ? FBgn0086357 Secondary Identifier  ? CG9539
Name  ? Sec61alpha Source  FlyBase
  • synonyms:
  • SEC61ALPHA,
  • DSec61alpha,
  • anon-WO0118547.195,
  • effector for neural death and degeneration 2,
  • FBan0009539,
  • SEC61-alpha,
  • FBgn0069450,
  • endd2,
  • BcDNA:LD29847,
  • FBgn0026571,
  • l(2)k04917,
  • BEST:LD29847,
  • FBgn0086357,
  • FBgn0047201,
  • LD29847,
  • CG9539,
  • Sec61a,
  • FBgn0031819,
  • anon-WO0118547.277,
  • FBgn0019697,
  • E(br)165,
  • 0455,
  • FBgn0062178,
  • Sec61,
  • FBgn0062125
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Lists
This Gene is in one list:
Fly classII (760)

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Genomics

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33 Alleles

DB identifier Symbol Allele Class Organism
FBal0156622 Sec61alpha[Ebr165]   Drosophila melanogaster
FBal0267535 Sec61alpha[GS76]   Drosophila melanogaster
FBal0267536 Sec61alpha[GS2158]   Drosophila melanogaster
FBal0267537 Sec61alpha[Scer\UAS.cKa]   Drosophila melanogaster
FBal0211735 Sec61alpha[CC00735]   Drosophila melanogaster
FBal0155815 Sec61alpha[Wee-P4]   Drosophila melanogaster
FBal0181568 Sec61alpha[d06903]   Drosophila melanogaster
FBal0064517 Sec61alpha[k13707]   Drosophila melanogaster
FBal0064518 Sec61alpha[k06011]   Drosophila melanogaster
FBal0064519 Sec61alpha[k05435]   Drosophila melanogaster
FBal0057094 Sec61alpha[k04917] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0155816 Sec61alpha[EP2108]   Drosophila melanogaster
FBal0130604 Sec61alpha[EP2567]   Drosophila melanogaster
FBal0130605 Sec61alpha[EP2180]   Drosophila melanogaster
FBal0095320 Sec61alpha[00455a]   Drosophila melanogaster
FBal0095319 Sec61alpha[03647a]   Drosophila melanogaster
FBal0095317 Sec61alpha[k08406]   Drosophila melanogaster
FBal0259175 Sec61alpha[KK102483]   Drosophila melanogaster
FBal0095318 Sec61alpha[k05432b]   Drosophila melanogaster
FBal0095843 Sec61alpha[GS2002]   Drosophila melanogaster
FBal0246697 Sec61alpha[1] amorphic allele - genetic evidence Drosophila melanogaster
FBal0246698 Sec61alpha[t4.4]   Drosophila melanogaster
FBal0217718 Sec61alpha[MB07934]   Drosophila melanogaster
FBal0152193 Sec61alpha[P560ex25] wild-type allele Drosophila melanogaster
FBal0152190 Sec61alpha[dsRNA.cKa]   Drosophila melanogaster
FBal0181569 Sec61alpha[ZCL0488]   Drosophila melanogaster
FBal0261638 Sec61alpha[CPTI002894]   Drosophila melanogaster
FBal0152191 Sec61alpha[dsRNA.Scer\UAS]   Drosophila melanogaster
FBal0152192 Sec61alpha[Scer\UAS.cKa.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0263380 Sec61alpha[HMS01472]   Drosophila melanogaster

163 Clones

Secondary Identifier DB identifier
ESG0119a.B21_A02 FBcl0002391
AT30684 FBcl0020775
AT17705 FBcl0020783
AT13990 FBcl0020785
AT17710 FBcl0020789
AT17740 FBcl0020793
AT23071 FBcl0020795
ESG017a.E21_A06 FBcl0008101
ESG0120b.B21.1_E11 FBcl0010353
EK194323 FBcl0049036
EK204001 FBcl0049054
EK234608 FBcl0049092
EK145702 FBcl0049132
EK141024 FBcl0049210
EK268045 FBcl0049570
EK221513 FBcl0050350
EK262129 FBcl0050622
EC31166 FBcl0066107
EC37157 FBcl0066109
EC31374 FBcl0066111
EN07161 FBcl0094885
EN13357 FBcl0094891
GH09874 FBcl0106807
GH13142 FBcl0106911
LD10083 FBcl0152270
LD29847 FBcl0164942
LD47182 FBcl0165736
LD27787 FBcl0165954
LP02784 FBcl0180638
LP19279 FBcl0180750

4 Exons

DB identifier Symbol
FBgn0086357:4 Sec61alpha:4
FBgn0086357:3 Sec61alpha:3
FBgn0086357:2 Sec61alpha:2
FBgn0086357:1 Sec61alpha:1

1 Transcripts

DB identifier Gene
FBtr0079266 Sec61alpha

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0079266-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079266-3-prime-utr Drosophila melanogaster

Interactions

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Other

13 Pathways

2 Cross References

Identifier
Source . Name
Subject . Primary Identifier
33905 NCBI Entrez Gene identifiers FBgn0086357
60062 BioGRID FBgn0086357

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier
Submission . Title
Cell Line . Name
Developmental Stage . Name 		Score
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 7088.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 6435.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 3479.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 5682.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 4299.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 2243.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 2356.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 3109.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1645.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 4337.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 4057.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1859.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 5330.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 3539.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 4055.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 3909.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 3774.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 4830.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 5015.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 3799.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 3152.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 6951.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 3541.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 4679.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2201.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 4319.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 3586.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 3704.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 5003.0
FBgn0086357 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 6030.0

3 Introns

DB identifier
Organism . Name
intron_FBgn0086357:4_FBgn0086357:3 Drosophila melanogaster
intron_FBgn0086357:3_FBgn0086357:2 Drosophila melanogaster
intron_FBgn0086357:2_FBgn0086357:1 Drosophila melanogaster

23 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation Sec61alpha Decreased cell size -2.66   19216764
Lipid storage Sec61alpha none 0.107741449   19067489
Lipid storage Sec61alpha none 1.377884087   19067489
ERK signaling Sec61alpha ERK activation reduced weak   17086199
Constitutive protein secretion and Golgi organization (1) Sec61alpha Decreased horseradish peroxidase protein expression sp   16452979
Constitutive protein secretion and Golgi organization (2) Sec61alpha Fused Golgi membranes with endoplasmic reticulum np   16452979
Cell size and cell-cycle regulation (1) Sec61alpha none sp   16496002
Influenza replication Sec61alpha Decreased Influenza replication -4.19/-2.23   18615016
Combinatorial effect with methyl methanesulphonate (2) Sec61alpha none sp   19543366
Muscle morphogenesis and function (1) Sec61alpha none np   20220848
Heat nociception (1) Sec61alpha none -1.17   21074052
Heart development and function (1) Sec61alpha none 1   20371351
Serratia marcescens infection (1) Sec61alpha none -1.29   19520911
Notch pathway regulation (4) Sec61alpha none 0   19363474
Adiposity regulation (1) Sec61alpha none 1.289   20074523
RTK-Ras-ERK pathway regulation (1) Sec61alpha none 0.82 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Sec61alpha none -0.46 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Sec61alpha none 0.31 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Sec61alpha none 0.91 30 minutes sSpitz stimulation 22028469
Wnt proteins secretion Sec61alpha none -0.3   22094269
Hippo pathway regulation Sec61alpha none -1.13   23263283
Glycosylation regulation (1) Sec61alpha none sp   21203496
Huntingtin (Htt) aggregates formation Sec61alpha Decreased formation of mutant Huntingtin (Httex1-Qn) protein aggregates np   20100940

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