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Gene : Mkk4 D. melanogaster

DB identifier  ? FBgn0024326 Secondary Identifier  ? CG9738
Name  ? MAP kinase kinase 4 Source  FlyBase
  • synonyms:
  • FBgn0040310,
  • CG9738,
  • 142758_at,
  • FBgn0024950,
  • SEK1/MKK4,
  • CT27508,
  • JNK kinase 2,
  • DMKK4,
  • FBan0009738,
  • MKK4,
  • MAP kinase kinase 4,
  • D-MKK4,
  • hep,
  • MAPKK4,
  • Drosophila MAP kinase kinase 4,
  • Mpk4,
  • FBgn0024326,
  • JNKK2

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35 Alleles

DB identifier Symbol Allele Class Organism
FBal0243039 Mkk4[e01485]   Drosophila melanogaster
FBal0243040 Mkk4[Scer\UAS.T:Avic\GFP-YFP]   Drosophila melanogaster
FBal0265728 Mkk4[G48]   Drosophila melanogaster
FBal0265729 Mkk4[G356]   Drosophila melanogaster
FBal0265730 Mkk4[G673]   Drosophila melanogaster
FBal0265731 Mkk4[G344]   Drosophila melanogaster
FBal0265732 Mkk4[G993]   Drosophila melanogaster
FBal0265733 Mkk4[G451]   Drosophila melanogaster
FBal0265734 Mkk4[G201]   Drosophila melanogaster
FBal0265735 Mkk4[G343]   Drosophila melanogaster
FBal0265736 Mkk4[G894]   Drosophila melanogaster
FBal0265737 Mkk4[G136]   Drosophila melanogaster
FBal0265738 Mkk4[G863]   Drosophila melanogaster
FBal0265739 Mkk4[G414]   Drosophila melanogaster
FBal0265740 Mkk4[G39]   Drosophila melanogaster
FBal0265741 Mkk4[G583]   Drosophila melanogaster
FBal0265742 Mkk4[G657]   Drosophila melanogaster
FBal0265743 Mkk4[G504]   Drosophila melanogaster
FBal0265744 Mkk4[G270]   Drosophila melanogaster
FBal0265745 Mkk4[G587]   Drosophila melanogaster
FBal0265746 Mkk4[G1010]   Drosophila melanogaster
FBal0265747 Mkk4[G680]   Drosophila melanogaster
FBal0265748 Mkk4[G262]   Drosophila melanogaster
FBal0265749 Mkk4[tub.cGa]   Drosophila melanogaster
FBal0265750 Mkk4[Scer\UAS.cGa]   Drosophila melanogaster
FBal0265751 Mkk4[Asp.Scer\UAS]   Drosophila melanogaster
FBal0265752 Mkk4[Mut.Scer\UAS]   Drosophila melanogaster
FBal0281526 Mkk4[HMS02524]   Drosophila melanogaster
FBal0147776 Mkk4[dsRNA.cCa]   Drosophila melanogaster
FBal0090572 Mkk4[Act5C.PH]   Drosophila melanogaster

132 Clones

Secondary Identifier DB identifier
DPiM_RE70055 FBcl0741337
EK227062 FBcl0021198
EK226008 FBcl0023922
EK242738 FBcl0015062
EK097308 FBcl0033628
EK182257 FBcl0038982
EK170849 FBcl0041200
EK155227 FBcl0044100
EK185626 FBcl0044120
EK250846 FBcl0045112
EK119439 FBcl0045136
EK204012 FBcl0048958
EK119415 FBcl0049748
EK292831 FBcl0053296
EC28485 FBcl0073381
EP09552 FBcl0089755
EP14401 FBcl0089763
GH03821 FBcl0108927
GH08878 FBcl0108935
GH27726 FBcl0108957
GH14629 FBcl0108979
EK019844 FBcl0140014
EK224316 FBcl0140754
EK070930 FBcl0140766
EK040048 FBcl0140770
EK097031 FBcl0140778
EK097029 FBcl0140792
EK276260 FBcl0140816
EK159144 FBcl0140890
EK275847 FBcl0140908

7 Exons

DB identifier Symbol
FBgn0024326:7 Mkk4:7
FBgn0024326:6 Mkk4:6
FBgn0024326:5 Mkk4:5
FBgn0024326:4 Mkk4:4
FBgn0024326:2 Mkk4:2
FBgn0024326:3 Mkk4:3
FBgn0024326:1 Mkk4:1

3 Transcripts

DB identifier Gene
FBtr0334320 Mkk4
FBtr0300443 Mkk4
FBtr0081892 Mkk4

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0081892-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0300443-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0334320-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081892-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0300443-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0334320-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
41020 NCBI Entrez Gene identifiers FBgn0024326
66196 BioGRID FBgn0024326

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1281.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1424.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 870.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1200.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1457.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1237.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 4994.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1294.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1160.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2083.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1604.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 917.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1929.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1100.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1730.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1707.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1785.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1716.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1549.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1646.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1983.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1942.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1488.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1651.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1312.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 3590.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1151.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1408.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1606.0
FBgn0024326 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1583.0

6 Introns

DB identifier
Organism . Name
intron_FBgn0024326:7_FBgn0024326:6 Drosophila melanogaster
intron_FBgn0024326:6_FBgn0024326:5 Drosophila melanogaster
intron_FBgn0024326:5_FBgn0024326:4 Drosophila melanogaster
intron_FBgn0024326:4_FBgn0024326:2 Drosophila melanogaster
intron_FBgn0024326:4_FBgn0024326:3 Drosophila melanogaster
intron_FBgn0024326:4_FBgn0024326:1 Drosophila melanogaster

33 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Mkk4 none -1.570713104   19067489
Lipid storage Mkk4 none -1.317862588   19067489
Cell cycle regulation (1) Mkk4 Chromosome alignment defects sp   15616552
Cell cycle regulation (2) Mkk4 none np   15616552
Cell size and cell-cycle regulation (1) Mkk4 none sp   16496002
Cell size and cell-cycle regulation (1) Mkk4 none sp   16496002
Cell size and cell-cycle regulation (1) Mkk4 none sp   16496002
Muscle morphogenesis and function (1) Mkk4 none np   20220848
Muscle morphogenesis and function (1) Mkk4 none np   20220848
Heat nociception (1) Mkk4 none -1.17   21074052
Heat nociception (1) Mkk4 none -0.95   21074052
Heart development and function (1) Mkk4 none 1   20371351
Heart development and function (1) Mkk4 none 1   20371351
Serratia marcescens infection (1) Mkk4 Decreased viability after Serratia marcescens infection -1.81889763779527   19520911
Serratia marcescens infection (2) Mkk4 none sp   19520911
Serratia marcescens infection (4) Mkk4 Decreased viability after Serratia marcescens infection sp   19520911
Serratia marcescens infection (5) Mkk4 Viable np   19520911
Notch pathway regulation (4) Mkk4 Bristle morphology defects, notum malformation death sp   19363474
Notch pathway regulation (4) Mkk4 Bristle morphology defects 5   19363474
PGN-induced dJNK phosphorylation Mkk4 Decreased P-JNK protein expression with PGN -2.53 15 min PGN induction 19893628
Pol II elongation Mkk4 none 96 20 min heat shock 19279664
Blood cell homeostasis regulation (1) Mkk4 none np   20540764
Blood cell homeostasis regulation (2) Mkk4 none np   20540764
Actin organization and cell morphology (1) Mkk4 none np   19265526
Actin organization and cell morphology (2) Mkk4 none np   19265526
Actin organization and cell morphology (3) Mkk4 none np   19265526
Actin organization and cell morphology (4) Mkk4 none np   19265526
Actin organization and cell morphology (5) Mkk4 none np   19265526
Actin organization and cell morphology (6) Mkk4 none np   19265526
Vaccinia virus infection Mkk4 none sp   20585561

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