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Gene : nbs D. melanogaster

DB identifier  ? FBgn0261530 Secondary Identifier  ? CG6754
Name  ? nbs Source  FlyBase
  • synonyms:
  • FBgn0036037,
  • NBS,
  • l(3)67BDp,
  • Nijmegen breakage syndrome,
  • CG6754,
  • NBS1,
  • l(3)67BDr,
  • lethal (3) 67BDp,
  • FBan0006754,
  • lethal (3) 67BDr,
  • FBgn0261530,
  • FBgn0026198,
  • Dnbs1,
  • l(3)e77A1,
  • FBgn0002218,
  • 6754,
  • FBgn0086349,
  • FBgn0002220

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17 Alleles

DB identifier Symbol Allele Class Organism
FBal0240174 nbs[defl-Delta]   Drosophila melanogaster
FBal0009778 nbs[1] amorphic allele - genetic evidence Drosophila melanogaster
FBal0178690 nbs[EY15506] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0258871 nbs[KK101013]   Drosophila melanogaster
FBal0240649 nbs[Delta180]   Drosophila melanogaster
FBal0260677 nbs[SM9]   Drosophila melanogaster
FBal0285732 nbs[+t5.2]   Drosophila melanogaster
FBal0240791 nbs[Scer\UAS.cOa]   Drosophila melanogaster
FBal0009780 nbs[2]   Drosophila melanogaster
FBal0210177 nbs[GD12399]   Drosophila melanogaster
FBal0247440 nbs[434.T:SV5\V5]   Drosophila melanogaster
FBal0247441 nbs[M1.T:SV5\V5]   Drosophila melanogaster
FBal0247442 nbs[M2.T:SV5\V5]   Drosophila melanogaster
FBal0247443 nbs[M3.T:SV5\V5]   Drosophila melanogaster
FBal0247444 nbs[M4.T:SV5\V5]   Drosophila melanogaster
FBal0247445 nbs[M5.T:SV5\V5]   Drosophila melanogaster
FBal0247446 nbs[M7]   Drosophila melanogaster

82 Clones

Secondary Identifier DB identifier
UUGC0722 FBcl0003895
AT31044 FBcl0014031
AT03327 FBcl0014101
AT05781 FBcl0014319
AT09710 FBcl0016715
EC22637 FBcl0063733
EP21347 FBcl0077207
EP10222 FBcl0077343
EK068217 FBcl0080198
EK015963 FBcl0080212
GH18605 FBcl0116461
GH18430 FBcl0116463
GM13403 FBcl0144841
LD44438 FBcl0169366
LD26919 FBcl0169413
LD27676 FBcl0169425
LD22566 FBcl0169433
LD29727 FBcl0169437
LP13419 FBcl0184455
SD04620 FBcl0280449
SD07492 FBcl0280502
Dmel_neb_013478_0940_1918 FBcl0381788
CK01.86B.E9 FBcl0442768
CK01.16A.H10 FBcl0442775
RP003458503 FBcl0656061
RP003642781 FBcl0656062
RP003167862 FBcl0673036
RP003236505 FBcl0673037
RP003479872 FBcl0673038
RP003357248 FBcl0673039

6 Exons

DB identifier Symbol
FBgn0261530:4 nbs:4
FBgn0261530:2 nbs:2
FBgn0261530:1 nbs:1
FBgn0261530:6 nbs:6
FBgn0261530:3 nbs:3
FBgn0261530:5 nbs:5

3 Transcripts

DB identifier Gene
FBtr0306041 nbs
FBtr0306039 nbs
FBtr0306040 nbs

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0306039-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0306040-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0306041-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0306039-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0306040-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0306041-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
44259 NCBI Entrez Gene identifiers FBgn0261530
68926 BioGRID FBgn0261530

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

7 Introns

DB identifier
Organism . Name
intron_FBgn0261530:6_FBgn0261530:3 Drosophila melanogaster
intron_FBgn0261530:3_FBgn0261530:2 Drosophila melanogaster
intron_FBgn0261530:2_FBgn0261530:1 Drosophila melanogaster
intron_FBgn0261530:6_FBgn0261530:4 Drosophila melanogaster
intron_FBgn0261530:4_FBgn0261530:2 Drosophila melanogaster
intron_FBgn0261530:6_FBgn0261530:5 Drosophila melanogaster
intron_FBgn0261530:5_FBgn0261530:2 Drosophila melanogaster

23 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage nbs none -0.051988402   19067489
Lipid storage nbs none 0.037498769   19067489
ERK signaling nbs ERK activation increased weak   17086199
Cell size and cell-cycle regulation (1) nbs none sp   16496002
Combinatorial effect with methyl methanesulphonate (2) nbs none sp   19543366
Muscle morphogenesis and function (1) nbs none np   20220848
Muscle morphogenesis and function (1) nbs none np   20220848
Heat nociception (1) nbs none -1.17   21074052
Heat nociception (1) nbs none -1.17   21074052
Heart development and function (1) nbs none 1   20371351
Serratia marcescens infection (1) nbs none 0.231343283582089   19520911
Notch pathway regulation (4) nbs Loss of bristles 1   19363474
Notch pathway regulation (4) nbs Colour defects, notum malformation death sp   19363474
G2-M DNA damage checkpoint regulation (2) nbs Increased histone H3 phosphorylation with doxorubicin 27.41 with doxorubicin 21205937
G2-M DNA damage checkpoint regulation (2) nbs Increased histone H3 phosphorylation with etoposide 27.44 with etoposide 21205937
G2-M DNA damage checkpoint regulation (2) nbs none 24.95 X-ray exposure 21205937
G2-M DNA damage checkpoint regulation (2) nbs none 9.31 with bleocin 21205937
Adiposity regulation (1) nbs none -0.319   20074523
RTK-Ras-ERK pathway regulation (1) nbs none 0.1 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) nbs none 0.69 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) nbs none 0.09 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) nbs none 0.95 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation nbs none 1.13   23263283

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