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Gene : CSN5 D. melanogaster

DB identifier  ? FBgn0027053 Secondary Identifier  ? CG14884
Name  ? COP9 complex homolog subunit 5 Source  FlyBase
  • synonyms:
  • l(3)L4032,
  • JadBp,
  • CG14884,
  • Jun activation domain binding protein,
  • BcDNA.LD14392,
  • BcDNA:LD14392,
  • Csn5,
  • FBgn0027053,
  • FBan0014884,
  • JAB1,
  • l(3)89Cf,
  • FBgn0024551,
  • quo,
  • Drosophila COP9 signalosome homolog 5,
  • DCH5,
  • CSN-5,
  • JAB1/CSN5,
  • l(3)M203,
  • COP9 complex homolog subunit 5,
  • COP9 complex subunit 5,
  • FBgn0016027,
  • JUN activation domain-binding protein-1,
  • CH5

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35 Alleles

DB identifier Symbol Allele Class Organism
FBal0281125 CSN5[GL01151]   Drosophila melanogaster
FBal0087008 CSN5[L4032]   Drosophila melanogaster
FBal0217594 CSN5[D148N.hs]   Drosophila melanogaster
FBal0248803 CSN5[NIG.14884R]   Drosophila melanogaster
FBal0156808 CSN5[quo3]   Drosophila melanogaster
FBal0145145 CSN5[ex27]   Drosophila melanogaster
FBal0131310 CSN5[hs.PS]   Drosophila melanogaster
FBal0131315 CSN5[+t30]   Drosophila melanogaster
FBal0145149 CSN5[+tSa]   Drosophila melanogaster
FBal0145150 CSN5[+t6.6]   Drosophila melanogaster
FBal0145141 CSN5[quo-3]   Drosophila melanogaster
FBal0101784 CSN5[3]   Drosophila melanogaster
FBal0131314 CSN5[quo-1] loss of function allele Drosophila melanogaster
FBal0145146 CSN5[ex21]   Drosophila melanogaster
FBal0145148 CSN5[ex13]   Drosophila melanogaster
FBal0046085 CSN5[M255]   Drosophila melanogaster
FBal0145144 CSN5[ex35]   Drosophila melanogaster
FBal0093940 CSN5[M233]   Drosophila melanogaster
FBal0093941 CSN5[M203]   Drosophila melanogaster
FBal0145143 CSN5[ex9]   Drosophila melanogaster
FBal0141864 CSN5[null]   Drosophila melanogaster
FBal0156809 CSN5[dsRNA.cPa]   Drosophila melanogaster
FBal0101785 CSN5[2]   Drosophila melanogaster
FBal0131313 CSN5[N] loss of function allele Drosophila melanogaster
FBal0145142 CSN5[quo-2]   Drosophila melanogaster
FBal0131309 CSN5[unspecified]   Drosophila melanogaster
FBal0145147 CSN5[ex15]   Drosophila melanogaster
FBal0131312 CSN5[Scer\UAS.cSa]   Drosophila melanogaster
FBal0131311 CSN5[T:Hsap\MYC]   Drosophila melanogaster
FBal0286921 CSN5[Scer\UAS.ORF]   Drosophila melanogaster

29 Clones

Secondary Identifier DB identifier
DPiM_LD14392 FBcl0742085
ESG0114c.B21_C09 FBcl0006995
ESG0114c.B21_G09 FBcl0007163
EK188047 FBcl0061256
EK185119 FBcl0061262
EN16040 FBcl0091325
EN01721 FBcl0091327
GH20811 FBcl0118893
LD14392 FBcl0156838
LD19430 FBcl0157354
LD33883 FBcl0170080
LD37964 FBcl0171096
LD40523 FBcl0171152
LD27982 FBcl0171184
LD41962 FBcl0171212
LD35626 FBcl0171217
LD38384 FBcl0171240
LD36980 FBcl0171415
RE29827 FBcl0216316
RE21934 FBcl0216439
SD26745 FBcl0276669
SD17654 FBcl0287683
AT14388 FBcl0294526
LP02439 FBcl0320133
570000 FBcl0438495
522275 FBcl0438472
562146 FBcl0438523
62483 FBcl0438543
61763 FBcl0438564

4 Exons

DB identifier Symbol
FBgn0027053:1 CSN5:1
FBgn0027053:3 CSN5:3
FBgn0027053:4 CSN5:4
FBgn0027053:2 CSN5:2

2 Transcripts

DB identifier Gene
FBtr0334535 CSN5
FBtr0083292 CSN5

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0083292-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0334535-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083292-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0334535-3-prime-utr Drosophila melanogaster

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Other

0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
42000 NCBI Entrez Gene identifiers FBgn0027053
67045 BioGRID FBgn0027053

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1087.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1094.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1148.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1737.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1643.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 751.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 977.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1299.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 952.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2184.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1120.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1000.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 693.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1105.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1419.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1478.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1128.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1033.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1488.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1311.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1691.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1305.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1103.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 798.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 806.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1832.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1710.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 972.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 742.0
FBgn0027053 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 769.0

4 Introns

DB identifier
Organism . Name
intron_FBgn0027053:1_FBgn0027053:2 Drosophila melanogaster
intron_FBgn0027053:2_FBgn0027053:4 Drosophila melanogaster
intron_FBgn0027053:1_FBgn0027053:3 Drosophila melanogaster
intron_FBgn0027053:3_FBgn0027053:4 Drosophila melanogaster

23 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage CSN5 none -0.581525972   19067489
Lipid storage CSN5 none 0.88663762   19067489
Lipid storage CSN5 none 1.277972058   19067489
Lipid storage CSN5 none -1.52692154   19067489
Cell size and cell-cycle regulation (1) CSN5 Increased G1 DNA content, decreased G2 DNA content sp   16496002
Cell size and cell-cycle regulation (2) CSN5 none 1.348   16496002
Cell size and cell-cycle regulation (3) CSN5 Decreased cell number 413   16496002
Cell size and cell-cycle regulation (4) CSN5 none below threshold   16496002
G2-M DNA damage checkpoint regulation (2) CSN5 Increased histone H3 phosphorylation with doxorubicin 26.92 with doxorubicin 21205937
G2-M DNA damage checkpoint regulation (2) CSN5 Increased histone H3 phosphorylation with etoposide 34.93 with etoposide 21205937
G2-M DNA damage checkpoint regulation (2) CSN5 Increased histone H3 phosphorylation after X-ray exposure 51.49 X-ray exposure 21205937
G2-M DNA damage checkpoint regulation (2) CSN5 Increased histone H3 phosphorylation with bleocin 22.24 with bleocin 21205937
Blood cell homeostasis regulation (1) CSN5 none np   20540764
Blood cell homeostasis regulation (2) CSN5 Increased melanotic mass formation np   20540764
Blood cell homeostasis regulation (3) CSN5 none 0   20540764
Blood cell homeostasis regulation (4) CSN5 none 0   20540764
Blood cell homeostasis regulation (5) CSN5 none 0   20540764
RTK-Ras-ERK pathway regulation (1) CSN5 none 0.9 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) CSN5 none 0.63 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) CSN5 none 0.3 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) CSN5 Increased ERK phosphorylation after sSpitz and EGF stimulation 1.83 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation CSN5 none 2.1   23263283
Glycosylation regulation (1) CSN5 none sp   21203496

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