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Gene : Top2 D. melanogaster

DB identifier  ? FBgn0003732 Secondary Identifier  ? CG10223
Name  ? Topoisomerase 2 Source  FlyBase
  • synonyms:
  • CG10223,
  • type II topoisomerase,
  • DNA Topoisomeriase II,
  • DNA topoisomerase II,
  • TOP2,
  • FBgn0003732,
  • TOPOII,
  • TopII,
  • CHRAC,
  • type II DNA topoisomerase,
  • Top 2,
  • Topoisomerase II,
  • TOPO II,
  • dCHRAC,
  • FBan0010223,
  • dTopoII

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28 Alleles

DB identifier Symbol Allele Class Organism
FBal0243254 Top2[unspecified]   Drosophila melanogaster
FBal0282334 Top2[35-2]   Drosophila melanogaster
FBal0282325 Top2[Df17]   Drosophila melanogaster
FBal0282326 Top2[+t7.1]   Drosophila melanogaster
FBal0282327 Top2[17-1]   Drosophila melanogaster
FBal0282328 Top2[17-2]   Drosophila melanogaster
FBal0282329 Top2[17-3] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0282330 Top2[17-5]   Drosophila melanogaster
FBal0282331 Top2[17-6] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0282332 Top2[17-7] amorphic allele - molecular evidence Drosophila melanogaster
FBal0282333 Top2[35-1] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0282335 Top2[35-3] hypomorphic allele - molecular evidence Drosophila melanogaster
FBal0282336 Top2[35-4]   Drosophila melanogaster
FBal0282337 Top2[35-5] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0282338 Top2[35-6] hypomorphic allele - genetic evidence, hypomorphic allele - molecular evidence Drosophila melanogaster
FBal0282339 Top2[35-12] hypomorphic allele - genetic evidence, hypomorphic allele - molecular evidence Drosophila melanogaster
FBal0282340 Top2[35-13] hypomorphic allele - genetic evidence, hypomorphic allele - molecular evidence Drosophila melanogaster
FBal0282341 Top2[35-14] amorphic allele - molecular evidence Drosophila melanogaster
FBal0181197 Top2[LA00892]   Drosophila melanogaster
FBal0198257 Top2[MB04073]   Drosophila melanogaster
FBal0181195 Top2[d05357]   Drosophila melanogaster
FBal0245591 Top2[JF01300]   Drosophila melanogaster
FBal0181194 Top2[f05145]   Drosophila melanogaster
FBal0181196 Top2[c05388]   Drosophila melanogaster
FBal0270385 Top2[NIG.10223R]   Drosophila melanogaster
FBal0197918 Top2[dsRNA.cHa]   Drosophila melanogaster
FBal0262804 Top2[GL00338]   Drosophila melanogaster
FBal0208817 Top2[GD4570]   Drosophila melanogaster

135 Clones

Secondary Identifier DB identifier
AT29794 FBcl0020699
UUGC0818 FBcl0004607
EK056251 FBcl0090014
EK195117 FBcl0090088
EK173515 FBcl0090106
EK139154 FBcl0091392
EK170602 FBcl0091482
EK237002 FBcl0091530
EK112836 FBcl0091562
EK179748 FBcl0091578
EK055206 FBcl0091594
EK063840 FBcl0091608
EK049140 FBcl0091626
EK191956 FBcl0091646
EK229635 FBcl0091660
EK257044 FBcl0091674
GH01096 FBcl0113817
GH11413 FBcl0113851
GH09857 FBcl0113861
GH09845 FBcl0113863
GM07016 FBcl0140763
GM05438 FBcl0140785
GM04316 FBcl0140789
GM01217 FBcl0140795
GM30444 FBcl0145671
GM16411 FBcl0145672
GM21208 FBcl0145673
GM12611 FBcl0145674
GM22085 FBcl0145675
LD11893 FBcl0154931

7 Exons

DB identifier Symbol
FBgn0003732:7 Top2:7
FBgn0003732:5 Top2:5
FBgn0003732:4 Top2:4
FBgn0003732:3 Top2:3
FBgn0003732:2 Top2:2
FBgn0003732:6 Top2:6
FBgn0003732:1 Top2:1

2 Transcripts

DB identifier Gene
FBtr0081287 Top2
FBtr0332320 Top2

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0081287-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0332320-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081287-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0332320-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
35225 NCBI Entrez Gene identifiers FBgn0003732
61203 BioGRID FBgn0003732

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 2303.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 2726.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 2411.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 2787.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 2247.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1103.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1305.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 2389.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 710.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 3180.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 2885.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 2809.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1553.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1878.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 3244.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 2426.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1674.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2184.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 2358.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1753.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 2152.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 2298.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 2042.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1640.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2089.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 4520.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 6539.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 5487.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 3574.0
FBgn0003732 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 2855.0

7 Introns

DB identifier
Organism . Name
intron_FBgn0003732:7_FBgn0003732:5 Drosophila melanogaster
intron_FBgn0003732:5_FBgn0003732:4 Drosophila melanogaster
intron_FBgn0003732:4_FBgn0003732:3 Drosophila melanogaster
intron_FBgn0003732:3_FBgn0003732:2 Drosophila melanogaster
intron_FBgn0003732:7_FBgn0003732:6 Drosophila melanogaster
intron_FBgn0003732:6_FBgn0003732:5 Drosophila melanogaster
intron_FBgn0003732:3_FBgn0003732:1 Drosophila melanogaster

27 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Top2 none 0.219352581   19067489
Lipid storage Top2 none 0.010175199   19067489
ERK signaling Top2 ERK activation increased weak   17086199
Alternative splicing Top2 none sp   15492211
Cell size and cell-cycle regulation (1) Top2 none sp   16496002
Mitosis Top2 Chromosome condensation defect np   17412918
Microtubule assembly and organization Top2 Abnormal spindle, chromosome alignment defect, increased number of cells in prometaphase np   18463163
Muscle morphogenesis and function (1) Top2 Lethal np   20220848
Heat nociception (1) Top2 Developmentally lethal 0.38   21074052
Heart development and function (1) Top2 none 1   20371351
Serratia marcescens infection (1) Top2 Decreased viability after Serratia marcescens infection -3.71830985915492   19520911
Serratia marcescens infection (2) Top2 none sp   19520911
Serratia marcescens infection (4) Top2 none sp   19520911
Notch pathway regulation (4) Top2 Notum malformation death 9   19363474
G2-M DNA damage checkpoint regulation (2) Top2 Increased histone H3 phosphorylation with doxorubicin 102.24 with doxorubicin 21205937
G2-M DNA damage checkpoint regulation (2) Top2 Increased histone H3 phosphorylation with etoposide 95.33 with etoposide 21205937
G2-M DNA damage checkpoint regulation (2) Top2 Increased histone H3 phosphorylation after X-ray exposure 51.38 X-ray exposure 21205937
G2-M DNA damage checkpoint regulation (2) Top2 Increased histone H3 phosphorylation with bleocin 18.74 with bleocin 21205937
Blood cell homeostasis regulation (1) Top2 none np   20540764
Blood cell homeostasis regulation (2) Top2 none np   20540764
RTK-Ras-ERK pathway regulation (1) Top2 none -0.37 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Top2 none -0.96 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Top2 none -0.06 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Top2 none -1.01 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation Top2 none 1.19   23263283
Glycosylation regulation (1) Top2 Increased alpha1,6-fucose Chp glycosylation sp   21203496
Glycosylation regulation (2) Top2 none np   21203496

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