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Gene : Prosbeta7 D. melanogaster

DB identifier  ? FBgn0250746 Secondary Identifier  ? CG12000
Name  ? Proteasome beta7 subunit Source  FlyBase
  • synonyms:
  • Beta-7,
  • 12000,
  • FBgn0250746,
  • beta7,
  • FBgn0037314,
  • Prosbeta4,
  • 154275_at,
  • FBan0012000,
  • anon-WO0118547.326,
  • beta-4,
  • GC12000,
  • CG12000,
  • beta-type 4 subunit,
  • FBgn0243587,
  • Prosbeta7,
  • FBgn0062092

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10 Alleles

DB identifier Symbol Allele Class Organism
FBal0286423 Prosbeta7[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286424 Prosbeta7[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0266443 Prosbeta7[HMS00122]   Drosophila melanogaster
FBal0187554 Prosbeta7[f06946]   Drosophila melanogaster
FBal0187555 Prosbeta7[e02000]   Drosophila melanogaster
FBal0199644 Prosbeta7[GD7457]   Drosophila melanogaster
FBal0235522 Prosbeta7[KK108365]   Drosophila melanogaster
FBal0162504 Prosbeta7[EY10024]   Drosophila melanogaster
FBal0222904 Prosbeta7[5-HA-2642]   Drosophila melanogaster
FBal0187553 Prosbeta7[f07292]   Drosophila melanogaster

114 Clones

Secondary Identifier DB identifier
bs50c06 FBcl0047341
EK243523 FBcl0049650
EK174605 FBcl0049684
EK053031 FBcl0049692
EK263744 FBcl0049716
EK243538 FBcl0049820
EK287046 FBcl0049978
EC37623 FBcl0061711
EN02020 FBcl0091289
EN06110 FBcl0091291
GH07232 FBcl0110065
GH10240 FBcl0110169
GH04464 FBcl0110533
GH03012 FBcl0112573
GH17251 FBcl0114385
GM10324 FBcl0137915
GM10332 FBcl0137917
GM01826 FBcl0137919
GM04527 FBcl0137921
GM10780 FBcl0137923
GM28418 FBcl0144120
LD15365 FBcl0153552
LD07750 FBcl0153556
LD16267 FBcl0153691
LD12967 FBcl0153834
LD08740 FBcl0154885
LD05586 FBcl0154893
LD25457 FBcl0166635
LD24366 FBcl0166735
LD28377 FBcl0166803

4 Exons

DB identifier Symbol
FBgn0250746:4 Prosbeta7:4
FBgn0250746:2 Prosbeta7:2
FBgn0250746:1 Prosbeta7:1
FBgn0250746:3 Prosbeta7:3

2 Transcripts

DB identifier Gene
FBtr0078805 Prosbeta7
FBtr0078806 Prosbeta7

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0078805-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0078806-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0078805-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0078806-3-prime-utr Drosophila melanogaster

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74 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
40639 NCBI Entrez Gene identifiers FBgn0250746
65850 BioGRID FBgn0250746

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1462.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1571.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 882.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1470.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1651.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1828.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1233.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1189.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1077.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1340.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 886.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1352.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1041.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1321.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1507.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 856.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 674.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 652.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1102.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1467.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1101.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1372.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 804.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 996.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 795.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2794.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2557.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1512.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1105.0
FBgn0250746 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 806.0

3 Introns

DB identifier
Organism . Name
intron_FBgn0250746:4_FBgn0250746:2 Drosophila melanogaster
intron_FBgn0250746:2_FBgn0250746:1 Drosophila melanogaster
intron_FBgn0250746:3_FBgn0250746:2 Drosophila melanogaster

32 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Prosbeta7 none -2.845049758   19067489
Lipid storage Prosbeta7 none 1.954136381   19067489
ERK signaling Prosbeta7 ERK activation reduced weak   17086199
Intracellular Listeria monocytogenes infection Prosbeta7 Decreased GFP protein expression strong   16020693
Hedgehog signaling Prosbeta7 Decreased Hedgehog reporter activity -3.26   16311596
Constitutive protein secretion and Golgi organization (1) Prosbeta7 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Prosbeta7 Decreased G1 DNA content, increased G2 cell size, decreased viability sp   16496002
Cell size and cell-cycle regulation (2) Prosbeta7 none 1.185   16496002
Cell size and cell-cycle regulation (3) Prosbeta7 none 449   16496002
Cell size and cell-cycle regulation (4) Prosbeta7 none below threshold   16496002
Candida albicans phagocytosis (1) Prosbeta7 none np   16336044
Influenza replication Prosbeta7 Decreased Influenza replication -0.46/-3.31   18615016
Combinatorial effect with methyl methanesulphonate (2) Prosbeta7 Synthetic lethal with methyl methanesulphonate sp   19543366
Mutant human huntingtin aggregation Prosbeta7 Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) Prosbeta7 Lethal np   20220848
Muscle morphogenesis and function (1) Prosbeta7 Lethal np   20220848
Heat nociception (1) Prosbeta7 Developmentally lethal 0.24   21074052
Heart development and function (1) Prosbeta7 none 1   20371351
Heart development and function (2) Prosbeta7 Decreased viability 3.66   20371351
Serratia marcescens infection (1) Prosbeta7 none 1.10294117647058   19520911
Notch pathway regulation (4) Prosbeta7 Completely lethal (pupal) sp   19363474
Notch pathway regulation (4) Prosbeta7 Completely lethal (pupal) sp   19363474
PGN-induced dJNK phosphorylation Prosbeta7 Increased P-JNK protein expression with PGN 2.08 60 min PGN induction 19893628
Hh pathway regulation Prosbeta7 Downregulation of Hh pathway -0.29461998903262   17903264
Hh pathway regulation Prosbeta7 Downregulation of Hh pathway -0.616396606733129   17903264
Self-renewal and differentiation in neural stem cells Prosbeta7 GFP aggregates number, GFP aggregates size, neuroblast more large cells, ganglion mother cell larger cell size, ganglion mother cell shorter lineages, neuroblast overproliferation, neuroblast underproliferation, lethal sp   21549331
RTK-Ras-ERK pathway regulation (1) Prosbeta7 Decreased ERK phosphorylation after EGF stimulation -1.84 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Prosbeta7 Decreased ERK phosphorylation after EGF stimulation -1.53 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Prosbeta7 none 0.45 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Prosbeta7 Increased ERK phosphorylation after sSpitz and EGF stimulation 1.92 10 minutes sSpitz stimulation 22028469

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