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Gene : CycE D. melanogaster

DB identifier  ? FBgn0010382 Secondary Identifier  ? CG3938
Name  ? Cyclin E Source  FlyBase
  • synonyms:
  • CYCE,
  • CycEI,
  • CyeE,
  • Cyc E,
  • FBgn0010318,
  • FBgn0010382,
  • l(2)br37,
  • DmCycE,
  • Cyclin-dependent kinase interactor 7,
  • CG3938,
  • BG:DS07108.3,
  • dCycE,
  • CyclE,
  • l(2)k05007,
  • fondue,
  • l35Dd,
  • DmcyclinE,
  • FBgn0022237,
  • Cyclin,
  • dm-cycE,
  • fond,
  • CDI7,
  • CyclinE,
  • dCyclinE,
  • Cyclin-E,
  • FBgn0015389,
  • FBgn0001984,
  • l(2)k02514,
  • l(2)05206,
  • FBan0003938,
  • cyclin E,
  • Cyc,
  • unnamed,
  • br37,
  • D-CycE,
  • l(2)35Dd,
  • l(2)k02602,
  • cycline E,
  • 3938

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100 Alleles

DB identifier Symbol Allele Class Organism
FBal0257095 CycE[HMS00060]   Drosophila melanogaster
FBal0184253 CycE[d01920]   Drosophila melanogaster
FBal0184252 CycE[d07253]   Drosophila melanogaster
FBal0184254 CycE[d01607]   Drosophila melanogaster
FBal0184251 CycE[e02245]   Drosophila melanogaster
FBal0033575 CycE[05277]   Drosophila melanogaster
FBal0033576 CycE[05278]   Drosophila melanogaster
FBal0033577 CycE[10427] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0033580 CycE[k00807]   Drosophila melanogaster
FBal0033581 CycE[k09109]   Drosophila melanogaster
FBal0184255 CycE[c02083]   Drosophila melanogaster
FBal0184256 CycE[c01170]   Drosophila melanogaster
FBal0043067 CycE[k02514]   Drosophila melanogaster
FBal0152658 CycE[GS-M986]   Drosophila melanogaster
FBal0152659 CycE[GS-A117]   Drosophila melanogaster
FBal0152660 CycE[GS-A095]   Drosophila melanogaster
FBal0059171 CycE[01672] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0065304 CycE[k02602]   Drosophila melanogaster
FBal0131283 CycE[EP2564]   Drosophila melanogaster
FBal0008525 CycE[05206] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0008524 CycE[k05007] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0045646 CycE[k05002a]   Drosophila melanogaster
FBal0259182 CycE[KK102511]   Drosophila melanogaster
FBal0093459 CycE[14.11G]   Drosophila melanogaster
FBal0098524 CycE[P7]   Drosophila melanogaster
FBal0098525 CycE[P2]   Drosophila melanogaster
FBal0060748 CycE[JP] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0128231 CycE[KG00239] loss of function allele Drosophila melanogaster
FBal0148092 CycE[KG07848]   Drosophila melanogaster
FBal0249201 CycE[MI01474]   Drosophila melanogaster

242 Clones

Secondary Identifier DB identifier
Dmel_dig_003399_0616_3483 FBcl0374587
DPiM_LD22682 FBcl0741957
AT26477 FBcl0040497
bs83a05 FBcl0056851
EP09409 FBcl0088019
EK259264 FBcl0098572
EK065555 FBcl0101514
EK188121 FBcl0102142
EK302252 FBcl0102182
EK181311 FBcl0102188
EK129636 FBcl0102208
EK129432 FBcl0102218
EK283156 FBcl0102252
EK255942 FBcl0102260
EK092225 FBcl0102266
EK302536 FBcl0102272
EK001038 FBcl0102278
EK051407 FBcl0102284
EK001014 FBcl0102290
EK308414 FBcl0102296
EK235629 FBcl0102302
EK223362 FBcl0102312
EK076330 FBcl0102314
EK067016 FBcl0102324
EK074637 FBcl0102330
EK071033 FBcl0102336
EK189033 FBcl0102340
EK117616 FBcl0102346
EK175457 FBcl0102350
EK221562 FBcl0102358

11 Exons

DB identifier Symbol
FBgn0010382:9 CycE:9
FBgn0010382:7 CycE:7
FBgn0010382:6 CycE:6
FBgn0010382:4 CycE:4
FBgn0010382:3 CycE:3
FBgn0010382:2 CycE:2
FBgn0010382:10 CycE:10
FBgn0010382:11 CycE:11
FBgn0010382:1 CycE:1
FBgn0010382:8 CycE:8
FBgn0010382:5 CycE:5

6 Transcripts

DB identifier Gene
FBtr0080775 CycE
FBtr0305561 CycE
FBtr0080776 CycE
FBtr0080773 CycE
FBtr0080774 CycE
FBtr0080777 CycE

12 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0080775-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0080774-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0080773-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0080776-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0080777-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0305561-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0080775-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0080774-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0080773-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0080776-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0080777-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0305561-3-prime-utr Drosophila melanogaster

Interactions

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Other

44 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
34924 NCBI Entrez Gene identifiers FBgn0010382
60939 BioGRID FBgn0010382

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from UniProt  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 706.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 483.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 794.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 669.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 704.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 650.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1519.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 931.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 377.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1229.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1352.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 716.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 903.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 456.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 746.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 497.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 748.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 638.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 533.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 602.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 680.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 770.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 484.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 525.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 424.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 10567.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 6881.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 5209.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 3525.0
FBgn0010382 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 3311.0

12 Introns

DB identifier
Organism . Name
intron_FBgn0010382:9_FBgn0010382:7 Drosophila melanogaster
intron_FBgn0010382:7_FBgn0010382:6 Drosophila melanogaster
intron_FBgn0010382:6_FBgn0010382:4 Drosophila melanogaster
intron_FBgn0010382:4_FBgn0010382:3 Drosophila melanogaster
intron_FBgn0010382:3_FBgn0010382:2 Drosophila melanogaster
intron_FBgn0010382:10_FBgn0010382:7 Drosophila melanogaster
intron_FBgn0010382:11_FBgn0010382:7 Drosophila melanogaster
intron_FBgn0010382:3_FBgn0010382:1 Drosophila melanogaster
intron_FBgn0010382:9_FBgn0010382:8 Drosophila melanogaster
intron_FBgn0010382:8_FBgn0010382:7 Drosophila melanogaster
intron_FBgn0010382:5_FBgn0010382:4 Drosophila melanogaster
intron_FBgn0010382:9_FBgn0010382:6 Drosophila melanogaster

30 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage CycE none -1.474167498   19067489
Lipid storage CycE none -2.108058972   19067489
Lipid storage CycE none -1.814279712   19067489
Lipid storage CycE none 2.813880801   19067489
ERK signaling CycE ERK activation reduced strong   17086199
Drosophila C virus infection CycE Drosophila C virus replication down np   17040126
Cell morphology CycE Morphology np   14527345
Cell cycle regulation (2) CycE none np   15616552
Intracellular Listeria monocytogenes infection CycE Increased GFP protein expression strong   16020693
Constitutive protein secretion and Golgi organization (1) CycE Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) CycE Increased G1 DNA content sp   16496002
Cell size and cell-cycle regulation (1) CycE Increased G1 DNA content, decreased G2 DNA content, increased G1 cell size, increased G2 cell size sp   16496002
Cell size and cell-cycle regulation (2) CycE none 1.29   16496002
Cell size and cell-cycle regulation (2) CycE none 1.322   16496002
Cell size and cell-cycle regulation (3) CycE none 460   16496002
Cell size and cell-cycle regulation (3) CycE none 463   16496002
Lipid storage CycE Fewer lipid droplets moderate   18408709
Combinatorial effect with methyl methanesulphonate (2) CycE Synthetic lethal with methyl methanesulphonate sp   19543366
Heat nociception (1) CycE none -0.43   21074052
Heart development and function (1) CycE none 1   20371351
S2 cell spreading CycE none np   21041442
Vaccinia virus infection CycE none sp   20585561
RTK-Ras-ERK pathway regulation (1) CycE Decreased ERK phosphorylation after EGF stimulation -5.35 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) CycE none -1.2 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) CycE Increased ERK phosphorylation after sSpitz and EGF stimulation 7.11 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) CycE Increased ERK phosphorylation after sSpitz and EGF stimulation 7.56 30 minutes sSpitz stimulation 22028469
Wg pathway regulation (1) CycE Decreased WgRluc and not changed sFluc protein expression weak   21886182
Hippo pathway regulation CycE none 0.42   23263283
Srp/Lz-induced transcriptional activation CycE Decreased Srp/Lz-induced transcription -6.8   20368357
Glycosylation regulation (1) CycE none sp   21203496

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