Genomics
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45 Alleles
157 Clones
13 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0015218:9 | eIF-4E:9 |
| FBgn0015218:8 | eIF-4E:8 |
| FBgn0015218:13 | eIF-4E:13 |
| FBgn0015218:11 | eIF-4E:11 |
| FBgn0015218:10 | eIF-4E:10 |
| FBgn0015218:5 | eIF-4E:5 |
| FBgn0015218:4 | eIF-4E:4 |
| FBgn0015218:3 | eIF-4E:3 |
| FBgn0015218:2 | eIF-4E:2 |
| FBgn0015218:1 | eIF-4E:1 |
| FBgn0015218:6 | eIF-4E:6 |
| FBgn0015218:7 | eIF-4E:7 |
| FBgn0015218:12 | eIF-4E:12 |
18 UTRs
Other
71 Pathways
- IRS-mediated signalling,
- SLBP independent Processing of Histone Pre-mRNAs,
- Regulation of Rheb GTPase activity by AMPK,
- DINR-mediated activation,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- Transport of the SLBP Dependant Mature mRNA,
- Insulin receptor mediated signaling,
- Deadenylation of mRNA,
- Immune System,
- PI3K Cascade,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- mRNA Processing,
- mTOR signalling,
- Interferon Signaling,
- IGF1R signaling cascade,
- RNA Pol II CTD phosphorylation and interaction with CE,
- Transport of the SLBP independent Mature mRNA,
- Signaling Pathways,
- Post-Elongation Processing of the Transcript,
- mTORC1-mediated signalling,
- Translation initiation complex formation,
- Insulin receptor signalling cascade,
- Regulation of AMPK activity via LKB1,
- 3' -UTR-mediated translational regulation,
- Elongation arrest and recovery,
- Post-Elongation Processing of Intronless pre-mRNA,
- Transcription,
- TOR signaling pathway,
- Ribosomal scanning and start codon recognition,
- Cleavage of Growing Transcript in the Termination Region,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- Metabolism of RNA,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- Metabolism of mRNA,
- IRS-related events,
- RNA Polymerase II Pre-transcription Events,
- Translation,
- Transport of Mature Transcript to Cytoplasm,
- Formation of the Early Elongation Complex,
- Antiviral mechanism by IFN-stimulated genes,
- Gene Expression,
- Processing of Capped Intronless Pre-mRNA,
- Insulin receptor recycling,
- RNA Polymerase II Transcription Termination,
- ISG15 antiviral mechanism,
- IRS-related events triggered by IGF1R,
- Cap-dependent Translation Initiation,
- PKB-mediated events,
- Insulin signaling pathway,
- Release of eIF4E,
- RNA Polymerase II Transcription,
- Processing of Intronless Pre-mRNAs,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- Eukaryotic Translation Initiation,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- Metabolism of proteins,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- RNA Polymerase II Promoter Escape,
- Formation of a pool of free 40S subunits,
- IRS activation,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- RNA Polymerase II Transcription Initiation,
- Deadenylation-dependent mRNA decay,
- RNA Polymerase II Transcription Elongation,
- Cytokine Signaling in Immune system,
- mRNA Capping,
- Formation of RNA Pol II elongation complex,
- Processing of Capped Intron-Containing Pre-mRNA
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 45525 | NCBI Entrez Gene identifiers | FBgn0015218 |
| 69740 | BioGRID | FBgn0015218 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
15 Introns
26 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF-4E | none | 1.809635118 | 19067489 | |
| Lipid storage | eIF-4E | none | 0.145067781 | 19067489 | |
| ERK signaling | eIF-4E | ERK activation reduced | weak | 17086199 | |
| Hedgehog signaling | eIF-4E | Increased Hedgehog reporter activity | 4.62 | 16311596 | |
| Cell size and cell-cycle regulation (1) | eIF-4E | none | sp | 16496002 | |
| Combinatorial effect with methyl methanesulphonate (2) | eIF-4E | none | sp | 19543366 | |
| Muscle morphogenesis and function (1) | eIF-4E | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | eIF-4E | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | eIF-4E | Split myofibril | np | 20220848 | |
| Heat nociception (1) | eIF-4E | Developmentally lethal | -1.17 | 21074052 | |
| Heart development and function (1) | eIF-4E | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | eIF-4E | none | 0.469135802469135 | 19520911 | |
| Notch pathway regulation (4) | eIF-4E | Completely lethal (pupal) | sp | 19363474 | |
| Muscle assembly and maintenance | eIF-4E | Muscles spread, myosin filaments striated, actin filaments lack striation | severe | 18359903 | |
| Hh pathway regulation | eIF-4E | none | 0.0735446152314015 | 17903264 | |
| Hh pathway regulation | eIF-4E | none | 0.0880434612253088 | 17903264 | |
| Self-renewal and differentiation in neural stem cells | eIF-4E | Neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell smaller cell size, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underproliferatio | sp | 21549331 | |
| Adiposity regulation (1) | eIF-4E | none | -0.601 | 20074523 | |
| S2 cell spreading | eIF-4E | none | np | 21041442 | |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -2.32 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -6.32 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | Decreased ERK phosphorylation after sSpitz and EGF stimulation | -1.64 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | none | -1.3 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF-4E | none | -1.18 | 23263283 | |
| Glycosylation regulation (1) | eIF-4E | Decreased (GlcNAc)n Chp glycosylation | sp | 21203496 | |
| Glycosylation regulation (2) | eIF-4E | Effect on Chp glycosylation | np | 21203496 |
