Genomics
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45 Alleles
157 Clones
13 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0015218:9 | eIF-4E:9 |
| FBgn0015218:8 | eIF-4E:8 |
| FBgn0015218:13 | eIF-4E:13 |
| FBgn0015218:11 | eIF-4E:11 |
| FBgn0015218:10 | eIF-4E:10 |
| FBgn0015218:5 | eIF-4E:5 |
| FBgn0015218:4 | eIF-4E:4 |
| FBgn0015218:3 | eIF-4E:3 |
| FBgn0015218:2 | eIF-4E:2 |
| FBgn0015218:1 | eIF-4E:1 |
| FBgn0015218:6 | eIF-4E:6 |
| FBgn0015218:7 | eIF-4E:7 |
| FBgn0015218:12 | eIF-4E:12 |
18 UTRs
Other
71 Pathways
- TOR signaling pathway,
- PI3K Cascade,
- Interferon Signaling,
- IRS-mediated signalling,
- Formation of a pool of free 40S subunits,
- Deadenylation of mRNA,
- Metabolism of RNA,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- Regulation of Rheb GTPase activity by AMPK,
- Ribosomal scanning and start codon recognition,
- IRS-related events,
- Elongation arrest and recovery,
- Transport of the SLBP independent Mature mRNA,
- IRS activation,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- Translation,
- Processing of Intronless Pre-mRNAs,
- Formation of RNA Pol II elongation complex,
- DINR-mediated activation,
- Post-Elongation Processing of the Transcript,
- Insulin receptor recycling,
- Cytokine Signaling in Immune system,
- RNA Polymerase II Transcription Termination,
- RNA Polymerase II Promoter Escape,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- Metabolism of proteins,
- Formation of the Early Elongation Complex,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- Insulin receptor mediated signaling,
- ISG15 antiviral mechanism,
- 3' -UTR-mediated translational regulation,
- RNA Polymerase II Pre-transcription Events,
- mRNA Capping,
- IGF1R signaling cascade,
- mRNA Processing,
- Eukaryotic Translation Initiation,
- PKB-mediated events,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- Deadenylation-dependent mRNA decay,
- Signaling Pathways,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Translation initiation complex formation,
- RNA Polymerase II Transcription Initiation,
- Cap-dependent Translation Initiation,
- SLBP independent Processing of Histone Pre-mRNAs,
- Release of eIF4E,
- RNA Pol II CTD phosphorylation and interaction with CE,
- Transport of the SLBP Dependant Mature mRNA,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Cleavage of Growing Transcript in the Termination Region,
- Post-Elongation Processing of Intronless pre-mRNA,
- mTORC1-mediated signalling,
- Antiviral mechanism by IFN-stimulated genes,
- mTOR signalling,
- RNA Polymerase II Transcription Elongation,
- Transport of Mature Transcript to Cytoplasm,
- Processing of Capped Intronless Pre-mRNA,
- Insulin receptor signalling cascade,
- IRS-related events triggered by IGF1R,
- Metabolism of mRNA,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- RNA Polymerase II Transcription,
- Immune System,
- Gene Expression,
- Transcription,
- Processing of Capped Intron-Containing Pre-mRNA,
- Regulation of AMPK activity via LKB1,
- Insulin signaling pathway
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 45525 | NCBI Entrez Gene identifiers | FBgn0015218 |
| 69740 | BioGRID | FBgn0015218 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
15 Introns
26 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF-4E | none | 1.809635118 | 19067489 | |
| Lipid storage | eIF-4E | none | 0.145067781 | 19067489 | |
| ERK signaling | eIF-4E | ERK activation reduced | weak | 17086199 | |
| Hedgehog signaling | eIF-4E | Increased Hedgehog reporter activity | 4.62 | 16311596 | |
| Cell size and cell-cycle regulation (1) | eIF-4E | none | sp | 16496002 | |
| Combinatorial effect with methyl methanesulphonate (2) | eIF-4E | none | sp | 19543366 | |
| Muscle morphogenesis and function (1) | eIF-4E | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | eIF-4E | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | eIF-4E | Split myofibril | np | 20220848 | |
| Heat nociception (1) | eIF-4E | Developmentally lethal | -1.17 | 21074052 | |
| Heart development and function (1) | eIF-4E | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | eIF-4E | none | 0.469135802469135 | 19520911 | |
| Notch pathway regulation (4) | eIF-4E | Completely lethal (pupal) | sp | 19363474 | |
| Muscle assembly and maintenance | eIF-4E | Muscles spread, myosin filaments striated, actin filaments lack striation | severe | 18359903 | |
| Hh pathway regulation | eIF-4E | none | 0.0735446152314015 | 17903264 | |
| Hh pathway regulation | eIF-4E | none | 0.0880434612253088 | 17903264 | |
| Self-renewal and differentiation in neural stem cells | eIF-4E | Neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell smaller cell size, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underproliferatio | sp | 21549331 | |
| Adiposity regulation (1) | eIF-4E | none | -0.601 | 20074523 | |
| S2 cell spreading | eIF-4E | none | np | 21041442 | |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -2.32 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -6.32 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | Decreased ERK phosphorylation after sSpitz and EGF stimulation | -1.64 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | none | -1.3 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF-4E | none | -1.18 | 23263283 | |
| Glycosylation regulation (1) | eIF-4E | Decreased (GlcNAc)n Chp glycosylation | sp | 21203496 | |
| Glycosylation regulation (2) | eIF-4E | Effect on Chp glycosylation | np | 21203496 |
