Genomics
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45 Alleles
157 Clones
13 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0015218:9 | eIF-4E:9 |
| FBgn0015218:8 | eIF-4E:8 |
| FBgn0015218:13 | eIF-4E:13 |
| FBgn0015218:11 | eIF-4E:11 |
| FBgn0015218:10 | eIF-4E:10 |
| FBgn0015218:5 | eIF-4E:5 |
| FBgn0015218:4 | eIF-4E:4 |
| FBgn0015218:3 | eIF-4E:3 |
| FBgn0015218:2 | eIF-4E:2 |
| FBgn0015218:1 | eIF-4E:1 |
| FBgn0015218:6 | eIF-4E:6 |
| FBgn0015218:7 | eIF-4E:7 |
| FBgn0015218:12 | eIF-4E:12 |
18 UTRs
Other
71 Pathways
- Transport of the SLBP independent Mature mRNA,
- Interferon Signaling,
- Metabolism of proteins,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- Cleavage of Growing Transcript in the Termination Region,
- Processing of Capped Intronless Pre-mRNA,
- DINR-mediated activation,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- Insulin receptor signalling cascade,
- Post-Elongation Processing of Intronless pre-mRNA,
- IRS-related events triggered by IGF1R,
- Ribosomal scanning and start codon recognition,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- Metabolism of RNA,
- ISG15 antiviral mechanism,
- IGF1R signaling cascade,
- Translation initiation complex formation,
- RNA Pol II CTD phosphorylation and interaction with CE,
- Regulation of Rheb GTPase activity by AMPK,
- Insulin receptor recycling,
- Cytokine Signaling in Immune system,
- Release of eIF4E,
- Formation of the Early Elongation Complex,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- Antiviral mechanism by IFN-stimulated genes,
- Transport of Mature Transcript to Cytoplasm,
- mTOR signalling,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- RNA Polymerase II Pre-transcription Events,
- Insulin receptor mediated signaling,
- Elongation arrest and recovery,
- mRNA Capping,
- SLBP independent Processing of Histone Pre-mRNAs,
- 3' -UTR-mediated translational regulation,
- RNA Polymerase II Transcription Initiation,
- Eukaryotic Translation Initiation,
- Deadenylation of mRNA,
- Transport of the SLBP Dependant Mature mRNA,
- Translation,
- Immune System,
- IRS-mediated signalling,
- Metabolism of mRNA,
- Post-Elongation Processing of the Transcript,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- IRS-related events,
- PI3K Cascade,
- Regulation of AMPK activity via LKB1,
- mRNA Processing,
- Cap-dependent Translation Initiation,
- Insulin signaling pathway,
- Gene Expression,
- RNA Polymerase II Transcription Termination,
- Transcription,
- Formation of a pool of free 40S subunits,
- Processing of Intronless Pre-mRNAs,
- RNA Polymerase II Promoter Escape,
- RNA Polymerase II Transcription Elongation,
- TOR signaling pathway,
- Processing of Capped Intron-Containing Pre-mRNA,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- mTORC1-mediated signalling,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- RNA Polymerase II Transcription,
- Formation of RNA Pol II elongation complex,
- IRS activation,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Signaling Pathways,
- PKB-mediated events,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- Deadenylation-dependent mRNA decay
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 45525 | NCBI Entrez Gene identifiers | FBgn0015218 |
| 69740 | BioGRID | FBgn0015218 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
15 Introns
26 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF-4E | none | 1.809635118 | 19067489 | |
| Lipid storage | eIF-4E | none | 0.145067781 | 19067489 | |
| ERK signaling | eIF-4E | ERK activation reduced | weak | 17086199 | |
| Hedgehog signaling | eIF-4E | Increased Hedgehog reporter activity | 4.62 | 16311596 | |
| Cell size and cell-cycle regulation (1) | eIF-4E | none | sp | 16496002 | |
| Combinatorial effect with methyl methanesulphonate (2) | eIF-4E | none | sp | 19543366 | |
| Muscle morphogenesis and function (1) | eIF-4E | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | eIF-4E | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | eIF-4E | Split myofibril | np | 20220848 | |
| Heat nociception (1) | eIF-4E | Developmentally lethal | -1.17 | 21074052 | |
| Heart development and function (1) | eIF-4E | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | eIF-4E | none | 0.469135802469135 | 19520911 | |
| Notch pathway regulation (4) | eIF-4E | Completely lethal (pupal) | sp | 19363474 | |
| Muscle assembly and maintenance | eIF-4E | Muscles spread, myosin filaments striated, actin filaments lack striation | severe | 18359903 | |
| Hh pathway regulation | eIF-4E | none | 0.0735446152314015 | 17903264 | |
| Hh pathway regulation | eIF-4E | none | 0.0880434612253088 | 17903264 | |
| Self-renewal and differentiation in neural stem cells | eIF-4E | Neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell smaller cell size, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underproliferatio | sp | 21549331 | |
| Adiposity regulation (1) | eIF-4E | none | -0.601 | 20074523 | |
| S2 cell spreading | eIF-4E | none | np | 21041442 | |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -2.32 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -6.32 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | Decreased ERK phosphorylation after sSpitz and EGF stimulation | -1.64 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | none | -1.3 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF-4E | none | -1.18 | 23263283 | |
| Glycosylation regulation (1) | eIF-4E | Decreased (GlcNAc)n Chp glycosylation | sp | 21203496 | |
| Glycosylation regulation (2) | eIF-4E | Effect on Chp glycosylation | np | 21203496 |
