Genomics
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45 Alleles
157 Clones
13 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0015218:9 | eIF-4E:9 |
| FBgn0015218:8 | eIF-4E:8 |
| FBgn0015218:13 | eIF-4E:13 |
| FBgn0015218:11 | eIF-4E:11 |
| FBgn0015218:10 | eIF-4E:10 |
| FBgn0015218:5 | eIF-4E:5 |
| FBgn0015218:4 | eIF-4E:4 |
| FBgn0015218:3 | eIF-4E:3 |
| FBgn0015218:2 | eIF-4E:2 |
| FBgn0015218:1 | eIF-4E:1 |
| FBgn0015218:6 | eIF-4E:6 |
| FBgn0015218:7 | eIF-4E:7 |
| FBgn0015218:12 | eIF-4E:12 |
18 UTRs
Other
71 Pathways
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- Translation,
- Processing of Capped Intronless Pre-mRNA,
- Formation of a pool of free 40S subunits,
- DINR-mediated activation,
- Immune System,
- RNA Polymerase II Pre-transcription Events,
- mRNA Capping,
- TOR signaling pathway,
- Transport of Mature Transcript to Cytoplasm,
- Eukaryotic Translation Initiation,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- Signaling Pathways,
- IRS-mediated signalling,
- Formation of RNA Pol II elongation complex,
- Post-Elongation Processing of Intronless pre-mRNA,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- Cleavage of Growing Transcript in the Termination Region,
- RNA Polymerase II Transcription Elongation,
- mRNA Processing,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- IRS-related events,
- IGF1R signaling cascade,
- PI3K Cascade,
- RNA Polymerase II Promoter Escape,
- RNA Polymerase II Transcription,
- Post-Elongation Processing of the Transcript,
- RNA Pol II CTD phosphorylation and interaction with CE,
- Cap-dependent Translation Initiation,
- Antiviral mechanism by IFN-stimulated genes,
- Regulation of Rheb GTPase activity by AMPK,
- Release of eIF4E,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Deadenylation of mRNA,
- Regulation of AMPK activity via LKB1,
- Transport of the SLBP Dependant Mature mRNA,
- SLBP independent Processing of Histone Pre-mRNAs,
- IRS activation,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- Gene Expression,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- mTORC1-mediated signalling,
- Elongation arrest and recovery,
- Transcription,
- Metabolism of proteins,
- Insulin signaling pathway,
- IRS-related events triggered by IGF1R,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Insulin receptor signalling cascade,
- Insulin receptor mediated signaling,
- Interferon Signaling,
- ISG15 antiviral mechanism,
- Ribosomal scanning and start codon recognition,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- Deadenylation-dependent mRNA decay,
- Transport of the SLBP independent Mature mRNA,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- 3' -UTR-mediated translational regulation,
- Metabolism of RNA,
- mTOR signalling,
- PKB-mediated events,
- Metabolism of mRNA,
- Processing of Intronless Pre-mRNAs,
- Translation initiation complex formation,
- RNA Polymerase II Transcription Termination,
- Insulin receptor recycling,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Cytokine Signaling in Immune system,
- Formation of the Early Elongation Complex,
- Processing of Capped Intron-Containing Pre-mRNA,
- RNA Polymerase II Transcription Initiation
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 45525 | NCBI Entrez Gene identifiers | FBgn0015218 |
| 69740 | BioGRID | FBgn0015218 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
15 Introns
26 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF-4E | none | 1.809635118 | 19067489 | |
| Lipid storage | eIF-4E | none | 0.145067781 | 19067489 | |
| ERK signaling | eIF-4E | ERK activation reduced | weak | 17086199 | |
| Hedgehog signaling | eIF-4E | Increased Hedgehog reporter activity | 4.62 | 16311596 | |
| Cell size and cell-cycle regulation (1) | eIF-4E | none | sp | 16496002 | |
| Combinatorial effect with methyl methanesulphonate (2) | eIF-4E | none | sp | 19543366 | |
| Muscle morphogenesis and function (1) | eIF-4E | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | eIF-4E | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | eIF-4E | Split myofibril | np | 20220848 | |
| Heat nociception (1) | eIF-4E | Developmentally lethal | -1.17 | 21074052 | |
| Heart development and function (1) | eIF-4E | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | eIF-4E | none | 0.469135802469135 | 19520911 | |
| Notch pathway regulation (4) | eIF-4E | Completely lethal (pupal) | sp | 19363474 | |
| Muscle assembly and maintenance | eIF-4E | Muscles spread, myosin filaments striated, actin filaments lack striation | severe | 18359903 | |
| Hh pathway regulation | eIF-4E | none | 0.0735446152314015 | 17903264 | |
| Hh pathway regulation | eIF-4E | none | 0.0880434612253088 | 17903264 | |
| Self-renewal and differentiation in neural stem cells | eIF-4E | Neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell smaller cell size, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underproliferatio | sp | 21549331 | |
| Adiposity regulation (1) | eIF-4E | none | -0.601 | 20074523 | |
| S2 cell spreading | eIF-4E | none | np | 21041442 | |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -2.32 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -6.32 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | Decreased ERK phosphorylation after sSpitz and EGF stimulation | -1.64 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | none | -1.3 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF-4E | none | -1.18 | 23263283 | |
| Glycosylation regulation (1) | eIF-4E | Decreased (GlcNAc)n Chp glycosylation | sp | 21203496 | |
| Glycosylation regulation (2) | eIF-4E | Effect on Chp glycosylation | np | 21203496 |
