Genomics
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45 Alleles
157 Clones
13 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0015218:9 | eIF-4E:9 |
| FBgn0015218:8 | eIF-4E:8 |
| FBgn0015218:13 | eIF-4E:13 |
| FBgn0015218:11 | eIF-4E:11 |
| FBgn0015218:10 | eIF-4E:10 |
| FBgn0015218:5 | eIF-4E:5 |
| FBgn0015218:4 | eIF-4E:4 |
| FBgn0015218:3 | eIF-4E:3 |
| FBgn0015218:2 | eIF-4E:2 |
| FBgn0015218:1 | eIF-4E:1 |
| FBgn0015218:6 | eIF-4E:6 |
| FBgn0015218:7 | eIF-4E:7 |
| FBgn0015218:12 | eIF-4E:12 |
18 UTRs
Other
71 Pathways
- IGF1R signaling cascade,
- Metabolism of mRNA,
- Regulation of Rheb GTPase activity by AMPK,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Deadenylation of mRNA,
- Elongation arrest and recovery,
- RNA Polymerase II Transcription,
- Deadenylation-dependent mRNA decay,
- Transport of the SLBP Dependant Mature mRNA,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Release of eIF4E,
- Translation initiation complex formation,
- Regulation of AMPK activity via LKB1,
- RNA Pol II CTD phosphorylation and interaction with CE,
- Cleavage of Growing Transcript in the Termination Region,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- Cytokine Signaling in Immune system,
- Formation of a pool of free 40S subunits,
- Interferon Signaling,
- Processing of Capped Intron-Containing Pre-mRNA,
- IRS-related events,
- Signaling Pathways,
- RNA Polymerase II Transcription Termination,
- RNA Polymerase II Transcription Initiation,
- Transport of the SLBP independent Mature mRNA,
- Transcription,
- Formation of RNA Pol II elongation complex,
- Metabolism of proteins,
- SLBP independent Processing of Histone Pre-mRNAs,
- Post-Elongation Processing of the Transcript,
- DINR-mediated activation,
- Formation of the Early Elongation Complex,
- Gene Expression,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- IRS-related events triggered by IGF1R,
- Processing of Intronless Pre-mRNAs,
- ISG15 antiviral mechanism,
- Ribosomal scanning and start codon recognition,
- RNA Polymerase II Pre-transcription Events,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- Insulin receptor mediated signaling,
- 3' -UTR-mediated translational regulation,
- Transport of Mature Transcript to Cytoplasm,
- Antiviral mechanism by IFN-stimulated genes,
- Post-Elongation Processing of Intronless pre-mRNA,
- TOR signaling pathway,
- RNA Polymerase II Transcription Elongation,
- Insulin receptor recycling,
- Insulin signaling pathway,
- Insulin receptor signalling cascade,
- RNA Polymerase II Promoter Escape,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- mRNA Processing,
- PI3K Cascade,
- Translation,
- Eukaryotic Translation Initiation,
- Processing of Capped Intronless Pre-mRNA,
- mRNA Capping,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- PKB-mediated events,
- mTORC1-mediated signalling,
- Immune System,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- Cap-dependent Translation Initiation,
- IRS activation,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- mTOR signalling,
- IRS-mediated signalling,
- Metabolism of RNA
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 45525 | NCBI Entrez Gene identifiers | FBgn0015218 |
| 69740 | BioGRID | FBgn0015218 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
15 Introns
26 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF-4E | none | 1.809635118 | 19067489 | |
| Lipid storage | eIF-4E | none | 0.145067781 | 19067489 | |
| ERK signaling | eIF-4E | ERK activation reduced | weak | 17086199 | |
| Hedgehog signaling | eIF-4E | Increased Hedgehog reporter activity | 4.62 | 16311596 | |
| Cell size and cell-cycle regulation (1) | eIF-4E | none | sp | 16496002 | |
| Combinatorial effect with methyl methanesulphonate (2) | eIF-4E | none | sp | 19543366 | |
| Muscle morphogenesis and function (1) | eIF-4E | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | eIF-4E | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | eIF-4E | Split myofibril | np | 20220848 | |
| Heat nociception (1) | eIF-4E | Developmentally lethal | -1.17 | 21074052 | |
| Heart development and function (1) | eIF-4E | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | eIF-4E | none | 0.469135802469135 | 19520911 | |
| Notch pathway regulation (4) | eIF-4E | Completely lethal (pupal) | sp | 19363474 | |
| Muscle assembly and maintenance | eIF-4E | Muscles spread, myosin filaments striated, actin filaments lack striation | severe | 18359903 | |
| Hh pathway regulation | eIF-4E | none | 0.0735446152314015 | 17903264 | |
| Hh pathway regulation | eIF-4E | none | 0.0880434612253088 | 17903264 | |
| Self-renewal and differentiation in neural stem cells | eIF-4E | Neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell smaller cell size, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underproliferatio | sp | 21549331 | |
| Adiposity regulation (1) | eIF-4E | none | -0.601 | 20074523 | |
| S2 cell spreading | eIF-4E | none | np | 21041442 | |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -2.32 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -6.32 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | Decreased ERK phosphorylation after sSpitz and EGF stimulation | -1.64 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | none | -1.3 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF-4E | none | -1.18 | 23263283 | |
| Glycosylation regulation (1) | eIF-4E | Decreased (GlcNAc)n Chp glycosylation | sp | 21203496 | |
| Glycosylation regulation (2) | eIF-4E | Effect on Chp glycosylation | np | 21203496 |
