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Gene : IntS3 D. melanogaster

DB identifier  ? FBgn0262117 Secondary Identifier  ? CG17665
Name  ? Integrator 3 Source  FlyBase
  • synonyms:
  • lethal (2) NC19,
  • Int3,
  • NC28,
  • FBgn0022283,
  • CG17665,
  • FBgn0039997,
  • FBgn0262117,
  • IR23,
  • FBan0017665,
  • l(2Rh)IR23,
  • l(2)IR23,
  • FBgn0067370,
  • lethal (2) NC28,
  • l(2)NC19,
  • FBgn0067367,
  • NC19,
  • l(2)NC28,
  • lethal (2) IR23

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13 Alleles

DB identifier Symbol Allele Class Organism
FBal0264079 IntS3[MI03529]   Drosophila melanogaster
FBal0150398 IntS3[NC28]   Drosophila melanogaster
FBal0245339 IntS3[HM04039]   Drosophila melanogaster
FBal0244784 IntS3[Lc]   Drosophila melanogaster
FBal0150401 IntS3[NC19]   Drosophila melanogaster
FBal0008986 IntS3[45-34]   Drosophila melanogaster
FBal0244786 IntS3[GD9439]   Drosophila melanogaster
FBal0244785 IntS3[NC89]   Drosophila melanogaster
FBal0150400 IntS3[NC86]   Drosophila melanogaster
FBal0008993 IntS3[45-71]   Drosophila melanogaster
FBal0008990 IntS3[45-61]   Drosophila melanogaster
FBal0064648 IntS3[IR23]   Drosophila melanogaster
FBal0162025 IntS3[EY09264]   Drosophila melanogaster

86 Clones

Secondary Identifier DB identifier
LD44383 FBcl0304112
LD02622 FBcl0304111
EK109905 FBcl0338195
EK242243 FBcl0340228
LD31627 FBcl0340229
EK030337 FBcl0340230
EK045248 FBcl0340231
EK213014 FBcl0340232
EK244318 FBcl0340233
EK236019 FBcl0340234
EK286330 FBcl0340235
EK203353 FBcl0340236
EK225206 FBcl0340237
EP19659 FBcl0340238
EK210653 FBcl0340239
EK130447 FBcl0340240
EK126427 FBcl0340241
EK099325 FBcl0340242
EK133912 FBcl0340243
EK154401 FBcl0340244
EK159546 FBcl0340245
EK213654 FBcl0340246
HL03310 FBcl0340247
EK053843 FBcl0340248
EK256238 FBcl0340249
EK251642 FBcl0340250
EK239815 FBcl0340251
RE20131 FBcl0340252
RE21161 FBcl0340253
RE22344 FBcl0340254

11 Exons

DB identifier Symbol
FBgn0262117:11 IntS3:11
FBgn0262117:10 IntS3:10
FBgn0262117:9 IntS3:9
FBgn0262117:8 IntS3:8
FBgn0262117:7 IntS3:7
FBgn0262117:6 IntS3:6
FBgn0262117:5 IntS3:5
FBgn0262117:4 IntS3:4
FBgn0262117:3 IntS3:3
FBgn0262117:2 IntS3:2
FBgn0262117:1 IntS3:1

1 Transcripts

DB identifier Gene
FBtr0111268 IntS3

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0111268-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0111268-3-prime-utr Drosophila melanogaster

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0 Pathways

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
3355010 NCBI Entrez Gene identifiers FBgn0262117

8 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

10 Introns

DB identifier
Organism . Name
intron_FBgn0262117:11_FBgn0262117:10 Drosophila melanogaster
intron_FBgn0262117:10_FBgn0262117:9 Drosophila melanogaster
intron_FBgn0262117:9_FBgn0262117:8 Drosophila melanogaster
intron_FBgn0262117:8_FBgn0262117:7 Drosophila melanogaster
intron_FBgn0262117:7_FBgn0262117:6 Drosophila melanogaster
intron_FBgn0262117:6_FBgn0262117:5 Drosophila melanogaster
intron_FBgn0262117:5_FBgn0262117:4 Drosophila melanogaster
intron_FBgn0262117:4_FBgn0262117:3 Drosophila melanogaster
intron_FBgn0262117:3_FBgn0262117:2 Drosophila melanogaster
intron_FBgn0262117:2_FBgn0262117:1 Drosophila melanogaster

28 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage IntS3 Decreased lipid droplet area -2.324444762   19067489
Lipid storage IntS3 Decreased lipid droplet area -3.63008576   19067489
ERK signaling IntS3 ERK activation increased strong   17086199
Wnt signaling IntS3 Decreased Wnt reporter activity -0.54   15817814
Mitochondrial biogenesis and function IntS3 Decreased mitochondrial citrate synthase activity 0.552   18042644
Muscle morphogenesis and function (1) IntS3 none np   20220848
Muscle morphogenesis and function (1) IntS3 none np   20220848
Heat nociception (1) IntS3 none -1.17   21074052
Heat nociception (1) IntS3 none 0.36   21074052
Heart development and function (1) IntS3 none 1   20371351
Heart development and function (1) IntS3 none 1   20371351
Serratia marcescens infection (1) IntS3 none -0.602564102564102   19520911
Serratia marcescens infection (1) IntS3 none 0.147727272727272   19520911
Serratia marcescens infection (1) IntS3 none -2.53703703703703   19520911
Notch pathway regulation (4) IntS3 none 0   19363474
Notch pathway regulation (4) IntS3 none 0   19363474
Notch pathway regulation (4) IntS3 Loss of bristles, bristle morphology defects sp   19363474
Notch induced transcription IntS3 none 3.3755 without Notch stimulation 20959007
Notch induced transcription IntS3 Upregulation of Notch pathway after Notch stimulation 2.5501 N(delta)ecn Notch stimulation 20959007
Notch induced transcription IntS3 none -1.3341 N(delta)ecn Notch stimulation 20959007
Adiposity regulation (1) IntS3 none -0.175   20074523
Adiposity regulation (1) IntS3 none 0.031   20074523
Secretory pathway regulation IntS3 Decreased BiP signal peptide and firefly luciferase fusion protein expression < -2   19942856
RTK-Ras-ERK pathway regulation (1) IntS3 none 0.77 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) IntS3 none -0.57 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) IntS3 none 0.78 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) IntS3 none 1 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation IntS3 none 1.71   23263283

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