Genomics
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36 Alleles
46 Clones
2 UTRs
Class | DB identifier |
Organism . Name |
---|---|---|
FivePrimeUTR | FBtr0080051-5-prime-utr | Drosophila melanogaster |
ThreePrimeUTR | FBtr0080051-3-prime-utr | Drosophila melanogaster |
Other
139 Pathways
- FCERI mediated MAPK activation,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- MASTL Facilitates Mitotic Progression,
- Double-Strand Break Repair,
- Mitotic Prometaphase,
- Cell Cycle, Mitotic,
- Toll Like Receptor 9 (TLR9) Cascade,
- M/G1 Transition,
- G0 and Early G1,
- Regulation of DNA replication,
- MyD88:Mal cascade initiated on plasma membrane,
- Toll Like Receptor 7/8 (TLR7/8) Cascade,
- Frs2-mediated activation,
- Mitotic Spindle Checkpoint,
- IRS-mediated signalling,
- Toll Like Receptor 10 (TLR10) Cascade,
- G2/M DNA damage checkpoint,
- Activated TLR4 signalling,
- TRAF6 Mediated Induction of proinflammatory cytokines,
- Interleukin-2 signaling,
- Insulin receptor mediated signaling,
- S Phase,
- Toll Like Receptor 3 (TLR3) Cascade,
- NCAM signaling for neurite out-growth,
- IRS-related events triggered by IGF1R,
- Prolonged ERK activation events,
- Signalling to RAS,
- MAP kinase activation in TLR cascade,
- M Phase,
- DINR-mediated activation,
- Mitotic G2-G2/M phases,
- Signaling by FGFR in disease,
- Insulin receptor signalling cascade,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- Homologous recombination repair of replication-independent double-strand breaks,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Signaling by PDGF,
- Signaling by ERBB4,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- Regulation of PLK1 Activity at G2/M Transition,
- Cyclin A/B1 associated events during G2/M transition,
- G1/S Transition,
- Gastrin-CREB signalling pathway via PKC and MAPK,
- Immune System,
- SHC1 events in ERBB2 signaling,
- Toll Like Receptor 4 (TLR4) Cascade,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- DAP12 interactions,
- G2/M Checkpoints,
- G2/M Transition,
- Amplification of signal from the kinetochores,
- Fc epsilon receptor (FCERI) signaling,
- Signaling by ERBB2,
- Mitotic M-M/G1 phases,
- IGF1R signaling cascade,
- Downstream signaling of activated FGFR,
- Insulin receptor recycling,
- Cell Cycle,
- Phosphorylation of the APC/C,
- Signalling to ERKs,
- SOS-mediated signalling,
- Toll Like Receptor 2 (TLR2) Cascade,
- Axon guidance,
- Resolution of Sister Chromatid Cohesion,
- SHC-related events triggered by IGF1R,
- Toll Like Receptor TLR6:TLR2 Cascade,
- SHC-related events,
- Cyclin A:Cdk2-associated events at S phase entry,
- FRS2-mediated cascade,
- DNA Replication,
- DNA Replication Pre-Initiation,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- Toll-Like Receptors Cascades,
- Activation of NIMA Kinases NEK9, NEK6, NEK7,
- G1/S-Specific Transcription,
- Signaling by SCF-KIT,
- G1/S DNA Damage Checkpoints,
- Insulin signaling pathway,
- Assembly of the pre-replicative complex,
- Innate Immune System,
- SHC1 events in ERBB4 signaling,
- DNA Repair,
- Mitotic G1-G1/S phases,
- Nuclear Pore Complex (NPC) Disassembly,
- MyD88 cascade initiated on plasma membrane,
- G2/M DNA replication checkpoint,
- Signaling by EGFR,
- NGF signalling via TRKA from the plasma membrane,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- E2F mediated regulation of DNA replication,
- Signaling by NGF,
- Cytokine Signaling in Immune system,
- Homologous Recombination Repair,
- p53-Independent G1/S DNA damage checkpoint,
- Toll Like Receptor 5 (TLR5) Cascade,
- Assembly of the ORC complex at the origin of replication,
- Developmental Biology,
- E2F-enabled inhibition of pre-replication complex formation,
- Cyclin B2 mediated events,
- MyD88-independent cascade,
- p53-Independent DNA Damage Response,
- Association of licensing factors with the pre-replicative complex,
- Signalling to p38 via RIT and RIN,
- Downstream signal transduction,
- DAP12 signaling,
- SHC-mediated signalling,
- Toll Like Receptor TLR1:TLR2 Cascade,
- Mitotic Prophase,
- Nuclear Envelope Breakdown,
- Signaling by GPCR,
- TRIF-mediated TLR3/TLR4 signaling,
- Regulation of APC/C activators between G1/S and early anaphase,
- ATM mediated response to DNA double-strand break,
- Signaling by FGFR,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- RAF/MAP kinase cascade,
- ERK activation,
- Polo-like kinase mediated events,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- APC/C-mediated degradation of cell cycle proteins,
- Signaling by EGFR in Cancer,
- Condensation of Prometaphase Chromosomes,
- ARMS-mediated activation,
- ERK1 activation,
- SCF-beta-TrCP mediated degradation of Emi1,
- SHC1 events in EGFR signaling,
- Signaling by Interleukins,
- Signaling Pathways,
- Signaling by Leptin,
- GRB2 events in ERBB2 signaling,
- MyD88 dependent cascade initiated on endosome,
- Disease,
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- IRS-related events,
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation,
- GRB2 events in EGFR signaling,
- Cell Cycle Checkpoints,
- Cyclin E associated events during G1/S transition,
- Regulation of mitotic cell cycle
2 Cross References
Identifier |
Source . Name |
Subject . Primary Identifier |
---|---|---|
34411 | NCBI Entrez Gene identifiers | FBgn0004106 |
60495 | BioGRID | FBgn0004106 |
11 Data Sets
Name | URL |
---|---|
FlyBase data set for Drosophila melanogaster | |
Swiss-Prot data set | http://ca.expasy.org/sprot |
Drosophila 12 Genomes Consortium homology | |
GenomeRNAi data set | |
TreeFam data set | |
Panther data set | |
IntAct interactions data set | |
BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
GO Annotation from FlyBase | |
FlyBase fasta data set for Drosophila melanogaster | |
Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
2 Introns
DB identifier |
Organism . Name |
---|---|
intron_FBgn0004106:3_FBgn0004106:2 | Drosophila melanogaster |
intron_FBgn0004106:2_FBgn0004106:1 | Drosophila melanogaster |
48 RNAi Results
Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
---|---|---|---|---|---|
Lipid storage | cdc2 | none | -1.624448355 | 19067489 | |
Lipid storage | cdc2 | none | 0.138448795 | 19067489 | |
Chlamydia caviae infection | cdc2 | Decreased Chlamydia caviae infection | np | 17967059 | |
ERK signaling | cdc2 | ERK activation reduced | strong | 17086199 | |
Drosophila C virus infection | cdc2 | Drosophila C virus replication down | np | 17040126 | |
Cell morphology | cdc2 | Morphology | np | 14527345 | |
Cell cycle regulation (1) | cdc2 | Increased G2/M DNA content, increased cell size, decreased cytokinetic index, increased number of cells in prometaphase and metaphase, chromosome defects | sp | 15616552 | |
Cell cycle regulation (2) | cdc2 | Increased G2/M DNA content, increased cell size | np | 15616552 | |
Cytokinesis regulation | cdc2 | Binucleate cells with decreased viability | weak | 15547975 | |
Intracellular Listeria monocytogenes infection | cdc2 | Increased GFP protein expression | moderate | 16020693 | |
Wnt signaling | cdc2 | Decreased Wnt reporter activity | -0.88 | 15817814 | |
Constitutive protein secretion and Golgi organization (1) | cdc2 | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
Cell size and cell-cycle regulation (1) | cdc2 | Decreased G1 DNA content, increased G2 DNA content | sp | 16496002 | |
Cell size and cell-cycle regulation (1) | cdc2 | none | sp | 16496002 | |
Cell size and cell-cycle regulation (1) | cdc2 | Decreased G1 DNA content, decreased viability | sp | 16496002 | |
Cell size and cell-cycle regulation (2) | cdc2 | none | 1.095 | 16496002 | |
Cell size and cell-cycle regulation (3) | cdc2 | none | 429 | 16496002 | |
Cell size and cell-cycle regulation (4) | cdc2 | none | below threshold | 16496002 | |
Influenza replication | cdc2 | Decreased Influenza replication | -2.1/-3.36 | 18615016 | |
Mitochondrial biogenesis and function | cdc2 | Increased mitochondrial citrate synthase activity | 2.003 | 18042644 | |
Lipid storage | cdc2 | Fewer lipid droplets | strong | 18408709 | |
Combinatorial effect with methyl methanesulphonate (1) | cdc2 | none | sp | 19543366 | |
Combinatorial effect with methyl methanesulphonate (2) | cdc2 | none | sp | 19543366 | |
Mutant human huntingtin aggregation | cdc2 | Decreased mutant human huntingtin aggregation | <= -2 | 19789644 | |
Muscle morphogenesis and function (1) | cdc2 | Lethal | np | 20220848 | |
Muscle morphogenesis and function (1) | cdc2 | none | np | 20220848 | |
Muscle morphogenesis and function (2) | cdc2 | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
Heat nociception (1) | cdc2 | Developmentally lethal | 0 | 21074052 | |
Heart development and function (1) | cdc2 | none | 1 | 20371351 | |
Serratia marcescens infection (1) | cdc2 | none | 0.465116279069767 | 19520911 |