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Gene : eIF-4a D. melanogaster

DB identifier  ? FBgn0001942 Secondary Identifier  ? CG9075
Name  ? Eukaryotic initiation factor 4a Source  FlyBase
  • synonyms:
  • L(2L)162,
  • FBgn0001942,
  • unnamed,
  • l(2)26Ac,
  • Su(dpp)YE9,
  • eIF4AI,
  • DmRH2,
  • eIF4A-I,
  • 2439,
  • l(2)gdh-4,
  • l(2)162,
  • Dm-eIF4A,
  • FBgn0024969,
  • anon-26Aa,
  • l(2)02439,
  • CG9075,
  • 9075,
  • EIF-4A,
  • translation initiation factor 4A,
  • FBgn0013523,
  • FBgn0022247,
  • FBgn0062252,
  • eukaryotic translation initiation factor 4A,
  • eIF-4a-I,
  • Eukaryotic initiation factor 4A,
  • pecan,
  • deIF4A,
  • FBgn0015864,
  • l(2)k01501,
  • FBgn0013406,
  • eIF 4A,
  • EIF4A,
  • FBan0009075,
  • anon26A

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71 Alleles

DB identifier Symbol Allele Class Organism
FBal0285959 eIF-4a[P02046]   Drosophila melanogaster
FBal0147183 eIF-4a[G29]   Drosophila melanogaster
FBal0211772 eIF-4a[CB03721]   Drosophila melanogaster
FBal0180054 eIF-4a[d06487]   Drosophila melanogaster
FBal0257600 eIF-4a[HMS00927]   Drosophila melanogaster
FBal0064594 eIF-4a[k01501]   Drosophila melanogaster
FBal0089710 eIF-4a[k09406]   Drosophila melanogaster
FBal0065252 eIF-4a[k09319a]   Drosophila melanogaster
FBal0065253 eIF-4a[k08120]   Drosophila melanogaster
FBal0065254 eIF-4a[k07120]   Drosophila melanogaster
FBal0065255 eIF-4a[k01801]   Drosophila melanogaster
FBal0003582 eIF-4a[02439]   Drosophila melanogaster
FBal0122991 eIF-4a[EP1011]   Drosophila melanogaster
FBal0130398 eIF-4a[EP2166]   Drosophila melanogaster
FBal0042532 eIF-4a[02623]   Drosophila melanogaster
FBal0042533 eIF-4a[06689]   Drosophila melanogaster
FBal0042534 eIF-4a[k05206]   Drosophila melanogaster
FBal0042535 eIF-4a[k07519]   Drosophila melanogaster
FBal0042536 eIF-4a[k08101]   Drosophila melanogaster
FBal0042537 eIF-4a[k08109]   Drosophila melanogaster
FBal0042538 eIF-4a[k09234]   Drosophila melanogaster
FBal0042539 eIF-4a[k14518]   Drosophila melanogaster
FBal0042540 eIF-4a[k14610]   Drosophila melanogaster
FBal0031633 eIF-4a[162-3]   Drosophila melanogaster
FBal0031637 eIF-4a[162-R1]   Drosophila melanogaster
FBal0031638 eIF-4a[162-R30]   Drosophila melanogaster
FBal0031639 eIF-4a[162-R35]   Drosophila melanogaster
FBal0031640 eIF-4a[162-R36]   Drosophila melanogaster
FBal0031641 eIF-4a[162-R39]   Drosophila melanogaster
FBal0031642 eIF-4a[162-R59]   Drosophila melanogaster

907 Clones

Secondary Identifier DB identifier
IP12276 FBcl0327558
RH28857 FBcl0327413
LD03766 FBcl0327559
LD08044 FBcl0327571
LD20491 FBcl0327583
LD01034 FBcl0327596
LD23235 FBcl0327618
GH01280 FBcl0327654
GH05176 FBcl0327660
GH09441 FBcl0327666
GH14039 FBcl0327677
GH18604 FBcl0327703
GH24417 FBcl0327724
LD35335 FBcl0327730
LD45940 FBcl0327742
LD41354 FBcl0327748
GH28703 FBcl0327754
LD38879 FBcl0327760
SD04778 FBcl0327766
LD47756 FBcl0327772
RE06762 FBcl0327789
RE25204 FBcl0327801
RE16662 FBcl0327807
AT14958 FBcl0021443
AT02170 FBcl0021451
AT29165 FBcl0021457
AT23385 FBcl0021461
AT13234 FBcl0021471
AT04436 FBcl0021475
AT28812 FBcl0021505

11 Exons

DB identifier Symbol
FBgn0001942:8 eIF-4a:8
FBgn0001942:2 eIF-4a:2
FBgn0001942:3 eIF-4a:3
FBgn0001942:4 eIF-4a:4
FBgn0001942:5 eIF-4a:5
FBgn0001942:6 eIF-4a:6
FBgn0001942:11 eIF-4a:11
FBgn0001942:1 eIF-4a:1
FBgn0001942:7 eIF-4a:7
FBgn0001942:9 eIF-4a:9
FBgn0001942:10 eIF-4a:10

6 Transcripts

DB identifier Gene
FBtr0307068 eIF-4a
FBtr0079177 eIF-4a
FBtr0079178 eIF-4a
FBtr0331201 eIF-4a
FBtr0079175 eIF-4a
FBtr0079176 eIF-4a

12 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0079175-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0079176-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0079177-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0079178-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0307068-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0331201-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079175-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079176-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079177-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079178-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0307068-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0331201-3-prime-utr Drosophila melanogaster

Interactions

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Other

50 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
33835 NCBI Entrez Gene identifiers FBgn0001942
60000 BioGRID FBgn0001942

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 17831.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 17239.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 20984.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 21156.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 17612.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 19160.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 12238.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 23381.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 14646.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 15061.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 13608.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 12868.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 16211.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 24244.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 24588.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 18124.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 15677.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 13766.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 21484.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 14884.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 19308.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 10683.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 12043.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 9344.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 9333.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 14571.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 16130.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 13581.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 13399.0
FBgn0001942 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 16065.0

10 Introns

DB identifier
Organism . Name
intron_FBgn0001942:2_FBgn0001942:3 Drosophila melanogaster
intron_FBgn0001942:3_FBgn0001942:4 Drosophila melanogaster
intron_FBgn0001942:4_FBgn0001942:5 Drosophila melanogaster
intron_FBgn0001942:5_FBgn0001942:6 Drosophila melanogaster
intron_FBgn0001942:6_FBgn0001942:11 Drosophila melanogaster
intron_FBgn0001942:1_FBgn0001942:3 Drosophila melanogaster
intron_FBgn0001942:5_FBgn0001942:8 Drosophila melanogaster
intron_FBgn0001942:5_FBgn0001942:7 Drosophila melanogaster
intron_FBgn0001942:6_FBgn0001942:9 Drosophila melanogaster
intron_FBgn0001942:6_FBgn0001942:10 Drosophila melanogaster

32 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage eIF-4a Increased lipid droplet area 3.147166637   19067489
Lipid storage eIF-4a Increased lipid droplet area 4.536100146   19067489
ERK signaling eIF-4a ERK activation reduced weak   17086199
Alternative splicing eIF-4a Alternative para (exon A/I) splicing sp   15492211
Constitutive protein secretion and Golgi organization (1) eIF-4a Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) eIF-4a none sp   16496002
Cell size and cell-cycle regulation (1) eIF-4a none sp   16496002
Cell size and cell-cycle regulation (1) eIF-4a Increased G1 DNA content, decreased G2 DNA content, decreased cytokinesis sp   16496002
Cell size and cell-cycle regulation (2) eIF-4a none 0.982   16496002
Cell size and cell-cycle regulation (3) eIF-4a none 448   16496002
Influenza replication eIF-4a Decreased Influenza replication -3.08/-2.91   18615016
Lipid storage eIF-4a Smaller sized lipid droplets, more dispersed strong   18408709
Microtubule assembly and organization eIF-4a Abnormal spindle, spindle poles splayed, increased number of cells in prometaphase np   18463163
Combinatorial effect with methyl methanesulphonate (2) eIF-4a Synthetic lethal with methyl methanesulphonate sp   19543366
Mutant human huntingtin aggregation eIF-4a Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) eIF-4a Lethal np   20220848
Muscle morphogenesis and function (1) eIF-4a Lethal np   20220848
Muscle morphogenesis and function (2) eIF-4a Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) eIF-4a none np   20220848
Heat nociception (1) eIF-4a none -0.62   21074052
Heart development and function (1) eIF-4a Larval lethal 0.4   20371351
Serratia marcescens infection (1) eIF-4a none 0.787878787878787   19520911
Notch pathway regulation (4) eIF-4a Completely lethal (pupal) sp   19363474
Notch pathway regulation (4) eIF-4a Completely lethal (before pupal) sp   19363474
Akt-TOR pathway negative feedback regulation eIF-4a Decreased dAkt phosphorylation after insulin stimulation -2.8 10 min insulin stimulation 20585550
Adiposity regulation (1) eIF-4a none -0.431   20074523
RTK-Ras-ERK pathway regulation (1) eIF-4a Decreased ERK phosphorylation after EGF stimulation -6.56 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) eIF-4a Decreased ERK phosphorylation after EGF stimulation -6.04 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) eIF-4a none 1.05 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) eIF-4a Increased ERK phosphorylation after sSpitz and EGF stimulation 1.86 10 minutes sSpitz stimulation 22028469

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