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Gene : E(z) D. melanogaster

DB identifier  ? FBgn0000629 Secondary Identifier  ? CG6502
Name  ? Enhancer of zeste Source  FlyBase
  • synonyms:
  • FBan0006502,
  • E(Z),
  • pco,
  • l(3)1902,
  • polycombeotic,
  • EZ,
  • l(3)B12,
  • Enhancer-of-Zeste,
  • l(3)ds12,
  • E[z],
  • l(3)SG17,
  • Enhancer of Zeste,
  • l(3)67Fa,
  • FBgn0000629,
  • FBgn0004710,
  • E(z)1,
  • CG6502,
  • pco/E(z),
  • Su(z)301

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119 Alleles

DB identifier Symbol Allele Class Organism
FBal0220860 E(z)[G4251]   Drosophila melanogaster
FBal0257100 E(z)[HMS00066]   Drosophila melanogaster
FBal0245673 E(z)[JF01402]   Drosophila melanogaster
FBal0285262 E(z)[T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0285263 E(z)[alphaTub84B.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0285264 E(z)[Act5C.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0285265 E(z)[63E11]   Drosophila melanogaster
FBal0003439 E(z)[60] antimorphic allele - genetic evidence, gain of function allele Drosophila melanogaster
FBal0192624 E(z)[EY21318]   Drosophila melanogaster
FBal0003404 E(z)[25] loss of function allele Drosophila melanogaster
FBal0003410 E(z)[31] loss of function allele Drosophila melanogaster
FBal0003415 E(z)[36] loss of function allele Drosophila melanogaster
FBal0003435 E(z)[56] loss of function allele Drosophila melanogaster
FBal0033656 E(z)[+t8.8]   Drosophila melanogaster
FBal0038830 E(z)[A]   Drosophila melanogaster
FBal0003454 E(z)[75] amorphic allele - genetic evidence, loss of function allele Drosophila melanogaster
FBal0003447 E(z)[68] loss of function allele, amorphic allele - genetic evidence Drosophila melanogaster
FBal0141835 E(z)[731]   Drosophila melanogaster
FBal0061959 E(z)[g.hs]   Drosophila melanogaster
FBal0061960 E(z)[c.hs]   Drosophila melanogaster
FBal0003388 E(z)[9] loss of function allele Drosophila melanogaster
FBal0003395 E(z)[16] loss of function allele Drosophila melanogaster
FBal0141838 E(z)[1025]   Drosophila melanogaster
FBal0003436 E(z)[57] loss of function allele Drosophila melanogaster
FBal0141833 E(z)[R699H.hs]   Drosophila melanogaster
FBal0141834 E(z)[H730K.hs]   Drosophila melanogaster
FBal0003419 E(z)[40] loss of function allele Drosophila melanogaster
FBal0003440 E(z)[61] heat sensitive loss of function allele Drosophila melanogaster
FBal0042527 E(z)[su4] amorphic allele - genetic evidence Drosophila melanogaster
FBal0003422 E(z)[43] loss of function allele Drosophila melanogaster

36 Clones

Secondary Identifier DB identifier
AT03143 FBcl0015755
AT27956 FBcl0015771
EK048205 FBcl0096884
EK234719 FBcl0097392
EK255413 FBcl0097978
GM23282 FBcl0145133
LD14652 FBcl0155613
LD30505 FBcl0169138
RE54527 FBcl0210232
RE16131 FBcl0210264
RE30421 FBcl0210280
RE39265 FBcl0210297
Dmel_dig_014282_0693_0325 FBcl0381837
FGC014D03 FBcl0385248
DPiM_LD30505 FBcl0738698
RP004076361 FBcl0656077
RP004236780 FBcl0673825
RP004212753 FBcl0673826
RP004191172 FBcl0673827
RP004216318 FBcl0673828
RP004536534 FBcl0673829
RP004531236 FBcl0673830
RP004246052 FBcl0673831
RP004451537 FBcl0673832
RP004177225 FBcl0673833
RP004144705 FBcl0673834
RP004122691 FBcl0673835
RP004261376 FBcl0673836
RP004263519 FBcl0673837
RP004216263 FBcl0673838

10 Exons

DB identifier Symbol
FBgn0000629:10 E(z):10
FBgn0000629:9 E(z):9
FBgn0000629:7 E(z):7
FBgn0000629:6 E(z):6
FBgn0000629:4 E(z):4
FBgn0000629:3 E(z):3
FBgn0000629:2 E(z):2
FBgn0000629:1 E(z):1
FBgn0000629:8 E(z):8
FBgn0000629:5 E(z):5

3 Transcripts

DB identifier Gene
FBtr0076279 E(z)
FBtr0273338 E(z)
FBtr0334067 E(z)

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0076279-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0273338-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0334067-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076279-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0273338-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0334067-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
39203 NCBI Entrez Gene identifiers FBgn0000629
64582 BioGRID FBgn0000629

12 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  
Fly Transcription Factor/microRNA Regulatory Network  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 598.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 738.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 315.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 449.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 579.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 274.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 239.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1026.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 237.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 593.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 438.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 256.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 438.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 392.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 626.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 340.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 460.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 596.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 419.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 537.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 455.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 715.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 503.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 324.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 425.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1157.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 555.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 986.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 694.0
FBgn0000629 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 502.0

10 Introns

DB identifier
Organism . Name
intron_FBgn0000629:10_FBgn0000629:9 Drosophila melanogaster
intron_FBgn0000629:9_FBgn0000629:7 Drosophila melanogaster
intron_FBgn0000629:7_FBgn0000629:6 Drosophila melanogaster
intron_FBgn0000629:6_FBgn0000629:4 Drosophila melanogaster
intron_FBgn0000629:4_FBgn0000629:3 Drosophila melanogaster
intron_FBgn0000629:3_FBgn0000629:2 Drosophila melanogaster
intron_FBgn0000629:2_FBgn0000629:1 Drosophila melanogaster
intron_FBgn0000629:8_FBgn0000629:7 Drosophila melanogaster
intron_FBgn0000629:6_FBgn0000629:5 Drosophila melanogaster
intron_FBgn0000629:5_FBgn0000629:4 Drosophila melanogaster

24 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage E(z) none 1.716476992   19067489
Lipid storage E(z) none 0.005749503   19067489
Cell size and cell-cycle regulation (1) E(z) none sp   16496002
Dendrite pattern formation E(z) Increased arborization np   16547170
Muscle morphogenesis and function (1) E(z) none np   20220848
Muscle morphogenesis and function (1) E(z) Weak flyer np   20220848
Muscle morphogenesis and function (2) E(z) none np   20220848
Heat nociception (1) E(z) none -1.17   21074052
Heart development and function (1) E(z) none 1   20371351
Heart development and function (1) E(z) none 1   20371351
Heart development and function (2) E(z) Decreased viability 4.39   20371351
Serratia marcescens infection (1) E(z) none -0.273972602739726   19520911
Serratia marcescens infection (1) E(z) none 0.291666666666666   19520911
Notch pathway regulation (4) E(z) Notum malformation death, overproliferation sp   19363474
Notch pathway regulation (4) E(z) Notum malformation death 8   19363474
Notch pathway regulation (4) E(z) none 0   19363474
Notch pathway regulation (1) E(z) Upregulation of Notch pathway np   20493818
Notch pathway regulation (2) E(z) Downregulation of Notch pathway; wing disc NRE:EGFP: down; wing disc myrRFP: accumulation, reduced; lethal sp en-GAL4 20493818
Notch pathway regulation (2) E(z) none np C96-GAL4 20493818
Adiposity regulation (1) E(z) none -0.123   20074523
Blood cell homeostasis regulation (1) E(z) none np   20540764
Blood cell homeostasis regulation (2) E(z) none np   20540764
Hippo pathway regulation E(z) none -0.16   23263283
Glycosylation regulation (1) E(z) none sp   21203496

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