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Gene : His2Av D. melanogaster

DB identifier  ? FBgn0001197 Secondary Identifier  ? CG5499
Name  ? Histone H2A variant Source  FlyBase
  • synonyms:
  • Histone-2A,
  • gammaH2Av,
  • H2A variant,
  • H2AvD,
  • H2A,
  • l(3)97Dd,
  • Histone-2av,
  • His2A,
  • H2a.V,
  • histone 2A variant,
  • Hist,
  • H2A.Z,
  • l(3)810,
  • Histone2Av,
  • Hist2av,
  • histone variant H2Av,
  • histone,
  • 5499,
  • H2A.X,
  • histone2A,
  • histone H2Av,
  • FBgn0010859,
  • H2AV_DROM,
  • l(3)05146,
  • FBgn0001197,
  • H2A.F/Z,
  • gamma-HIS2AV,
  • HIS,
  • l(3)L1602,
  • HisH2Av,
  • FBan0005499,
  • HIS2AVD,
  • histone H2A variant,
  • H2AV,
  • H2AZ,
  • CG5499,
  • histone2AvD,
  • gamma-H2Av,
  • H2AX,
  • HIS2AV,
  • His2

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46 Alleles

DB identifier Symbol Allele Class Organism
FBal0212251 His2Av[YD0140]   Drosophila melanogaster
FBal0283632 His2Av[N.Act5C.T:Zzzz\FLAG,T:Zzzz\His6,T:Avic\GFP,T:Hsap\MYC]   Drosophila melanogaster
FBal0283633 His2Av[C.Act5C.T:Zzzz\FLAG,T:Zzzz\His6,T:Avic\GFP]   Drosophila melanogaster
FBal0283634 His2Av[KR.Act5C.T:Avic\GFP]   Drosophila melanogaster
FBal0243272 His2Av[tCH322-97I07]   Drosophila melanogaster
FBal0195215 His2Av[cCa.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0147881 His2Av[G280]   Drosophila melanogaster
FBal0282346 His2Av[Scer\UAS.T:Zzzz\KO-mKO]   Drosophila melanogaster
FBal0211691 His2Av[CC00358]   Drosophila melanogaster
FBal0240306 His2Av[HM05177]   Drosophila melanogaster
FBal0285443 His2Av[cKa.T:Disc\RFP-mRFP]   Drosophila melanogaster
FBal0009530 His2Av[05146]   Drosophila melanogaster
FBal0101653 His2Av[L1602]   Drosophila melanogaster
FBal0259711 His2Av[KK108652]   Drosophila melanogaster
FBal0131007 His2Av[EP3641]   Drosophila melanogaster
FBal0095701 His2Av[GS3127]   Drosophila melanogaster
FBal0095702 His2Av[GS3052]   Drosophila melanogaster
FBal0033754 His2Av[+t4.1]   Drosophila melanogaster
FBal0098377 His2Av[tM7]   Drosophila melanogaster
FBal0098378 His2Av[tM6]   Drosophila melanogaster
FBal0098379 His2Av[tM4]   Drosophila melanogaster
FBal0098380 His2Av[tM3]   Drosophila melanogaster
FBal0098381 His2Av[tM2]   Drosophila melanogaster
FBal0098382 His2Av[tM1]   Drosophila melanogaster
FBal0098383 His2Av[tCT]   Drosophila melanogaster
FBal0098384 His2Av[+tM5]   Drosophila melanogaster
FBal0098385 His2Av[+t4.0]   Drosophila melanogaster
FBal0005491 His2Av[810] amorphic allele - genetic evidence Drosophila melanogaster
FBal0029842 His2Av[n1] amorphic allele - genetic evidence Drosophila melanogaster
FBal0263158 His2Av[HMS00162]   Drosophila melanogaster

167 Clones

Secondary Identifier DB identifier
DPiM_LD21568 FBcl0740817
UUGC0404 FBcl0001107
UUGC0664 FBcl0003391
EK302011 FBcl0005406
EK198407 FBcl0006746
EK215610 FBcl0007192
EK189554 FBcl0007600
EK281249 FBcl0007704
EK204406 FBcl0007898
EK112158 FBcl0008736
EK154202 FBcl0008756
EK256101 FBcl0008826
EK220228 FBcl0008932
EK043840 FBcl0009020
EK207618 FBcl0009042
EK123143 FBcl0009106
EK209416 FBcl0009260
EK209346 FBcl0009314
EK230915 FBcl0009336
EK227929 FBcl0009356
EK052222 FBcl0009392
EK065029 FBcl0009434
EC00759 FBcl0070343
EP15844 FBcl0086327
EN10212 FBcl0099639
GH21178 FBcl0135157
GH15210 FBcl0135223
GM07879 FBcl0142817
GM09014 FBcl0142818
GM05050 FBcl0142820

6 Exons

DB identifier Symbol
FBgn0001197:1 His2Av:1
FBgn0001197:2 His2Av:2
FBgn0001197:3 His2Av:3
FBgn0001197:5 His2Av:5
FBgn0001197:4 His2Av:4
FBgn0001197:6 His2Av:6

2 Transcripts

DB identifier Gene
FBtr0085062 His2Av
FBtr0334311 His2Av

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0085062-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0334311-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0085062-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0334311-3-prime-utr Drosophila melanogaster

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0 Pathways

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
43229 NCBI Entrez Gene identifiers FBgn0001197
3772139, 3772346, 3772556 NCBI Entrez Gene identifiers FBgn0001197
68120 BioGRID FBgn0001197

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 5223.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 6152.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 3201.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 4464.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 5146.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 14041.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 4831.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 5250.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 12507.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 6322.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 5401.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 5302.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 3185.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 6534.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 7266.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 6362.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 4832.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 6480.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 6300.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 5910.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 6205.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 4644.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 3766.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 3262.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 4713.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 12979.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 14508.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 12249.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 10189.0
FBgn0001197 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 11803.0

5 Introns

DB identifier
Organism . Name
intron_FBgn0001197:1_FBgn0001197:2 Drosophila melanogaster
intron_FBgn0001197:2_FBgn0001197:3 Drosophila melanogaster
intron_FBgn0001197:3_FBgn0001197:5 Drosophila melanogaster
intron_FBgn0001197:3_FBgn0001197:4 Drosophila melanogaster
intron_FBgn0001197:4_FBgn0001197:6 Drosophila melanogaster

22 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage His2Av none 0.71458861   19067489
Lipid storage His2Av none 0   19067489
Histone pre-mRNA processing His2Av Histone pre-mRNA processing defect 3   18042462
ERK signaling His2Av ERK activation reduced strong   17086199
Hedgehog signaling His2Av Increased Hedgehog reporter activity 4.62   16311596
Cell size and cell-cycle regulation (1) His2Av none sp   16496002
Combinatorial effect with methyl methanesulphonate (2) His2Av Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) His2Av Weak flyer np   20220848
Heat nociception (1) His2Av Increased noxious heat avoidance 8.53   21074052
Heat nociception (2) His2Av none 31.33333333   21074052
Heart development and function (1) His2Av none 0.8   20371351
Heart development and function (2) His2Av Decreased viability 4.36   20371351
Serratia marcescens infection (1) His2Av none 0.59047619047619   19520911
Notch pathway regulation (4) His2Av Notum malformation death 5   19363474
Hh pathway regulation His2Av Upregulation of Hh pathway 0.977495959655462   17903264
Hh pathway regulation His2Av Upregulation of Hh pathway 1.2969888211135   17903264
Adiposity regulation (1) His2Av none -0.281   20074523
RTK-Ras-ERK pathway regulation (1) His2Av none 0.01 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) His2Av Decreased ERK phosphorylation after EGF stimulation -2.06 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) His2Av none 0.28 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) His2Av none 1.18 10 minutes sSpitz stimulation 22028469
Wg pathway regulation (1) His2Av Decreased WgRluc and not changed sFluc protein expression weak   21886182

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